T3DB: Adhesion G protein-coupled receptor L2

Name	Adhesion G protein-coupled receptor L2
Synonyms	Calcium-independent alpha-latrotoxin receptor 2 CIRL-2 KIAA0786 Latrophilin homolog 1 Latrophilin-2 LEC1 Lectomedin-1 LPHH1 LPHN2
Gene Name	ADGRL2
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009043\|Adhesion G protein-coupled receptor L2 MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIE SANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTY KYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRT DTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKS GEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEA TWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPN QYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIIST TSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWP QTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAA SLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREK TCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTR VSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIY RSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDP DNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKD GVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG IDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLF PATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHS NTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFI FIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMW NDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP SAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFE KMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHH KELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRD SPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKE GCIPEGDVREGQMQLVTSL
Number of residues	1459
Molecular Weight	163347.39
Theoretical pI	Not Available
GO Classification	Functions latrotoxin receptor activity G-protein coupled receptor activity carbohydrate binding Processes cell surface receptor signaling pathway positive regulation of synapse assembly G-protein coupled receptor signaling pathway Components integral component of membrane
General Function	Latrotoxin receptor activity
Specific Function	Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.
Pfam Domain Function	7tm_2 (PF00002 ) HRM (PF02793 ) GPS (PF01825 ) GAIN (PF16489 ) Gal_Lectin (PF02140 ) Latrophilin (PF02354 ) OLF (PF02191 )
Transmembrane Regions	852-872 881-901 908-928 953-973 991-1011 1038-1058 1063-1083
GenBank Protein ID	Not Available
UniProtKB ID	O95490
UniProtKB Entry Name	AGRL2_HUMAN
Cellular Location	Membrane
Gene sequence	>lcl\|BSEQ0013581\|Adhesion G protein-coupled receptor L2 (ADGRL2) ATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTGTAATCAGCTTCTTA CCAAATACAGAAGGTTTCAGCAGAGCAGCTTTACCATTTGGGCTGGTGAGGCGAGAATTA TCCTGTGAAGGTTATTCTATAGATCTGCGATGCCCGGGCAGTGATGTCATCATGATTGAG AGCGCTAACTATGGTCGGACGGATGACAAGATTTGTGATGCTGACCCATTTCAGATGGAG AATACAGACTGCTACCTCCCCGATGCCTTCAAAATTATGACTCAAAGGTGCAACAATCGA ACACAGTGTATAGTAGTTACTGGGTCAGATGTGTTTCCTGATCCATGTCCTGGAACATAC AAATACCTTGAAGTCCAATATGAATGTGTCCCTTACATTTTTGTGTGTCCTGGGACCTTG AAAGCAATTGTGGACTCACCATGTATATATGAAGCTGAACAAAAGGCGGGTGCTTGGTGC AAGGACCCTCTTCAGGCTGCAGATAAAATTTATTTCATGCCCTGGACTCCCTATCGTACC GATACTTTAATAGAATATGCTTCTTTAGAAGATTTCCAAAATAGTCGCCAAACAACAACA TATAAACTTCCAAATCGAGTAGATGGTACTGGATTTGTGGTGTATGATGGTGCTGTCTTC TTTAACAAAGAAAGAACGAGGAATATTGTGAAATTTGACTTGAGGACTAGAATTAAGAGT GGCGAGGCCATAATTAACTATGCCAACTACCATGATACCTCACCATACAGATGGGGAGGA AAGACTGATATCGACCTAGCAGTTGATGAAAATGGTTTATGGGTCATTTACGCCACTGAA CAGAACAATGGAATGATAGTTATTAGCCAGCTGAATCCATACACTCTTCGATTTGAAGCA ACGTGGGAGACTGTATACGACAAACGTGCCGCATCAAATGCTTTTATGATATGCGGAGTC CTCTATGTGGTTAGGTCAGTTTATCAAGACAATGAAAGTGAAACAGGCAAGAACTCAATT GATTACATTTATAATACCCGATTAAACCGAGGAGAATATGTAGATGTTCCCTTCCCCAAC CAGTATCAGTATATTGCTGCAGTGGATTACAATCCAAGAGATAACCAACTTTACGTGTGG AACAATAACTTCATTTTACGATATTCTCTGGAGTTTGGTCCACCTGATCCTGCCCAAGTG CCTACCACAGCTGTGACAATAACTTCTTCAGCTGAGCTGTTCAAAACCATAATATCAACC ACAAGCACTACTTCACAGAAAGGCCCCATGAGCACAACTGTAGCTGGATCACAGGAAGGA AGCAAAGGGACAAAACCACCTCCAGCAGTTTCTACAACCAAAATTCCACCTATAACAAAT ATTTTTCCCCTGCCAGAGAGATTCTGTGAAGCATTAGACTCCAAGGGGATAAAGTGGCCT CAGACACAAAGGGGAATGATGGTTGAACGACCATGCCCTAAGGGAACAAGAGGAACTGCC TCATATCTCTGCATGATTTCCACTGGAACATGGAACCCTAAGGGCCCCGATCTTAGCAAC TGTACCTCACACTGGGTGAATCAGCTGGCTCAGAAGATCAGAAGCGGAGAAAATGCTGCT AGTCTTGCCAATGAACTGGCTAAACATACCAAAGGGCCAGTGTTTGCTGGGGATGTAAGT TCTTCAGTGAGATTGATGGAGCAGTTGGTGGACATCCTTGATGCACAGCTGCAGGAACTG AAACCTAGTGAAAAAGATTCAGCTGGACGGAGTTATAACAAGGCAATTGTTGACACAGTG GACAACCTTCTGAGACCCGAAGCTTTGGAATCATGGAAACATATGAATTCTTCTGAACAA GCACATACTGCAACAATGTTACTCGATACATTGGAAGAAGGAGCTTTTGTCCTAGCTGAC AATCTTTTAGAACCAACAAGGGTCTCAATGCCCACAGAAAATATTGTCCTGGAAGTTGCC GTACTCAGTACAGAAGGACAGATCCAAGACTTTAAATTTCCTCTGGGCATCAAAGGAGCA GGCAGCTCAATCCAACTGTCCGCAAATACCGTCAAACAGAACAGCAGGAATGGGCTTGCA AAGTTGGTGTTCATCATTTACCGGAGCCTGGGACAGTTCCTTAGTACAGAAAATGCAACC ATTAAACTGGGTGCTGATTTTATTGGTCGTAATAGCACCATTGCAGTGAACTCTCACGTC ATTTCAGTTTCAATCAATAAAGAGTCCAGCCGAGTATACCTGACTGATCCTGTGCTTTTT ACCCTGCCACACATTGATCCTGACAATTATTTCAATGCAAACTGCTCCTTCTGGAACTAC TCAGAGAGAACTATGATGGGATATTGGTCTACCCAGGGCTGCAAGCTGGTTGACACTAAT AAAACTCGAACAACGTGTGCATGCAGCCACCTAACCAATTTTGCAATTCTCATGGCCCAC AGGGAAATTGCATATAAAGATGGCGTTCATGAATTACTTCTTACAGTCATCACCTGGGTG GGAATTGTCATTTCCCTTGTTTGCCTGGCTATCTGCATCTTCACCTTCTGCTTTTTCCGT GGCCTACAGAGTGACCGAAATACTATTCACAAGAACCTTTGTATCAACCTTTTCATTGCT GAATTTATTTTCCTAATAGGCATTGATAAGACAAAATATGCGATTGCATGCCCAATATTT GCAGGACTTCTACACTTTTTCTTTTTGGCAGCTTTTGCTTGGATGTGCCTAGAAGGTGTG CAGCTCTACCTAATGTTAGTTGAAGTTTTTGAAAGTGAATATTCAAGGAAAAAATATTAC TATGTTGCTGGTTACTTGTTTCCTGCCACAGTGGTTGGAGTTTCAGCTGCTATTGACTAT AAGAGCTATGGAACAGAAAAAGCTTGCTGGCTTCATGTTGATAACTACTTTATATGGAGC TTCATTGGACCTGTTACCTTCATTATTCTGCTAAATATTATCTTCTTGGTGATCACATTG TGCAAAATGGTGAAGCATTCAAACACTTTGAAACCAGATTCTAGCAGGTTGGAAAACATT AAGTCTTGGGTGCTTGGCGCTTTCGCTCTTCTGTGTCTTCTTGGCCTCACCTGGTCCTTT GGGTTGCTTTTTATTAATGAGGAGACTATTGTGATGGCATATCTCTTCACTATATTTAAT GCTTTCCAGGGAGTGTTCATTTTCATCTTTCACTGTGCTCTCCAAAAGAAAGTACGAAAA GAATATGGCAAGTGCTTCAGACACTCATACTGCTGTGGAGGCCTCCCAACTGAGAGTCCC CACAGTTCAGTGAAGGCATCAACCACCAGAACCAGTGCTCGCTATTCCTCTGGCACACAG AGTCGTATAAGAAGAATGTGGAATGATACTGTGAGAAAACAATCAGAATCTTCTTTTATC TCAGGTGACATCAATAGCACTTCAACACTTAATCAAGGACATTCACTGAACAATGCCAGG GATACAAGTGCCATGGATACTCTACCGCTAAATGGTAATTTTAACAACAGCTACTCGCTG CACAAGGGTGACTATAATGACAGCGTGCAAGTTGTGGACTGTGGACTAAGTCTGAATGAT ACTGCTTTTGAGAAAATGATCATTTCAGAATTAGTGCACAACAACTTACGGGGCAGCAGC AAGACTCACAACCTCGAGCTCACGCTACCAGTCAAACCTGTGATTGGAGGTAGCAGCAGT GAAGATGATGCTATTGTGGCAGATGCTTCATCTTTAATGCACAGCGACAACCCAGGGCTG GAGCTCCATCACAAAGAACTCGAGGCACCACTTATTCCTCAGCGGACTCACTCCCTTCTG TACCAACCCCAGAAGAAAGTGAAGTCCGAGGGAACTGACAGCTATGTCTCCCAACTGACA GCAGAGGCTGAAGATCACCTACAGTCCCCCAACAGAGACTCTCTTTATACAAGCATGCCC AATCTTAGAGACTCTCCCTATCCGGAGAGCAGCCCTGACATGGAAGAAGACCTCTCTCCC TCCAGGAGGAGTGAGAATGAGGACATTTACTATAAAAGCATGCCAAATCTTGGAGCTGGC CATCAGCTTCAGATGTGCTACCAGATCAGCAGGGGCAATAGTGATGGTTATATAATCCCC ATTAACAAAGAAGGGTGTATTCCAGAAGGAGATGTTAGAGAAGGACAAATGCAGCTGGTT ACAAGTCTTTAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:18582
Chromosome Location	1
Locus	Not Available
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