Potassium voltage-gated channel subfamily H member 1
Name | Potassium voltage-gated channel subfamily H member 1 |
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Synonyms |
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Gene Name | KCNH1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008955|Potassium voltage-gated channel subfamily H member 1 MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS RRSSQSPQELFEISRPQSPESERDIFGAS |
Number of residues | 989 |
Molecular Weight | 111421.76 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Phosphorelay sensor kinase activity |
Specific Function | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). |
Pfam Domain Function | |
Transmembrane Regions | 221-241 249-269 295-315 350-370 377-397 478-498 |
GenBank Protein ID | Not Available |
UniProtKB ID | O95259 |
UniProtKB Entry Name | KCNH1_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0021435|Potassium voltage-gated channel subfamily H member 1 (KCNH1) ATGACCATGGCTGGGGGCAGGAGGGGACTAGTGGCCCCTCAAAACACGTTTCTGGAGAAT ATTGTTCGGCGGTCCAATGATACTAATTTTGTGTTGGGGAATGCTCAGATAGTGGACTGG CCTATTGTGTACAGCAATGATGGATTTTGCAAGCTGTCTGGCTATCACAGGGCAGAAGTG ATGCAAAAAAGCAGCACCTGCAGTTTTATGTATGGGGAGCTGACTGATAAAGACACGATT GAAAAAGTGCGGCAAACATTTGAGAACTATGAGATGAATTCCTTTGAAATTCTGATGTAC AAGAAGAACAGGACACCTGTGTGGTTCTTTGTGAAAATTGCTCCAATTCGAAACGAACAG GATAAAGTGGTTTTATTTCTTTGCACTTTCAGTGACATAACAGCTTTCAAACAGCCAATT GAGGATGATTCATGTAAAGGCTGGGGGAAGTTTGCTCGGCTGACAAGAGCACTGACAAGC AGCAGGGGTGTCCTGCAGCAGCTGGCTCCAAGCGTGCAAAAAGGCGAGAATGTCCACAAG CACTCCCGCCTGGCAGAGGTCCTACAGCTGGGCTCAGACATCCTTCCCCAGTACAAGCAA GAGGCACCAAAGACTCCCCCTCACATCATCTTACATTATTGTGTTTTTAAGACCACGTGG GATTGGATCATCTTGATCTTGACCTTCTATACAGCCATCTTGGTCCCTTATAATGTCTCC TTCAAAACCAGGCAGAATAATGTGGCCTGGCTGGTTGTTGATAGCATCGTGGATGTTATC TTTTTGGTGGACATTGTGCTCAATTTTCATACCACCTTTGTTGGACCAGCAGGGGAGGTG ATTTCTGACCCCAAACTTATCCGCATGAACTACCTGAAGACGTGGTTTGTGATTGACCTT CTGTCCTGTTTGCCATATGATGTCATCAACGCTTTTGAGAACGTGGATGAGGGCATCAGC AGCCTGTTCAGCTCTCTAAAAGTTGTCCGGCTGCTCCGTCTTGGGCGAGTGGCCCGTAAG CTGGACCACTACATTGAATATGGAGCTGCTGTGCTGGTCCTGCTGGTGTGTGTGTTTGGG CTGGCTGCACACTGGATGGCCTGCATCTGGTACAGCATTGGGGACTATGAGATCTTTGAC GAGGACACCAAGACAATCCGCAACAACAGCTGGCTGTACCAACTAGCGATGGACATTGGC ACCCCTTACCAGTTTAATGGGTCTGGCTCAGGGAAGTGGGAAGGTGGTCCCAGCAAGAAT TCTGTCTACATCTCCTCGTTGTATTTCACAATGACCAGCCTCACCAGTGTGGGCTTTGGG AACATCGCCCCATCCACAGACATTGAGAAGATCTTTGCAGTGGCCATCATGATGATTGGC TCACTTCTCTATGCCACCATCTTCGGGAATGTGACGACTATTTTCCAACAGATGTATGCC AACACCAACAGATACCATGAGATGCTCAACAGTGTTCGGGACTTCCTGAAGCTCTACCAG GTGCCAAAAGGATTGAGTGAGCGAGTAATGGATTATATTGTGTCCACTTGGTCCATGTCC AGAGGCATTGACACAGAGAAGGTCCTGCAGATCTGCCCCAAGGACATGAGAGCCGACATC TGCGTGCACCTGAACCGCAAGGTGTTCAAGGAGCACCCGGCCTTCCGGCTGGCCAGTGAT GGCTGCCTCCGGGCACTGGCCATGGAGTTCCAGACGGTGCACTGTGCCCCAGGGGACCTC ATCTACCATGCAGGAGAGAGCGTTGACAGCCTCTGCTTTGTGGTTTCTGGCTCCCTGGAG GTGATCCAAGATGATGAGGTGGTGGCCATTCTAGGAAAAGGAGACGTGTTTGGAGATGTG TTCTGGAAGGAAGCCACCCTTGCCCAGTCCTGTGCCAATGTTAGGGCCTTGACCTACTGT GATCTGCATGTGATCAAGCGGGATGCCCTGCAGAAAGTGCTGGAATTCTACACGGCCTTC TCCCATTCCTTCTCCCGGAACCTGATTCTGACGTACAACTTGAGGAAGAGGATTGTGTTC CGGAAGATCAGCGATGTGAAACGTGAAGAGGAAGAACGCATGAAACGAAAGAATGAGGCC CCCCTGATCTTGCCCCCGGACCACCCTGTCCGGCGCCTCTTCCAGAGATTCCGACAGCAG AAAGAGGCCAGGCTGGCAGCTGAGAGAGGGGGCCGGGACCTGGATGACCTAGATGTGGAG AAGGGCAATGTCCTTACAGAGCATGCCTCCGCCAACCACAGCCTCGTGAAGGCCAGCGTG GTCACCGTGCGTGAGAGTCCTGCCACGCCCGTATCCTTCCAGGCAGCCTCCACCTCCGGG GTGCCAGACCACGCAAAGCTACAGGCGCCAGGGTCCGAGTGCCTGGGCCCCAAGGGGGGC GGGGGCGATTGTGCCAAGCGCAAAAGCTGGGCCCGCTTCAAAGATGCTTGCGGGAAGAGT GAGGACTGGAACAAGGTGTCCAAGGCTGAGTCGATGGAGACACTTCCCGAGAGGACAAAA GCGTCAGGCGAGGCCACACTGAAGAAGACAGACTCGTGTGACAGTGGCATCACCAAGAGC GACTTGCGCCTGGACAACGTGGGTGAGGCCAGGAGTCCCCAGGATCGGAGTCCCATCCTG GCAGAGGTCAAGCATTCGTTCTACCCCATCCCTGAGCAGACGCTGCAGGCCACAGTCCTG GAGGTGAGGCACGAGCTGAAGGAGGACATCAAGGCCTTAAACGCCAAAATGACCAATATT GAGAAACAGCTCTCTGAGATACTCAGGATATTAACTTCCAGAAGATCCTCTCAGTCTCCT CAGGAGTTGTTTGAAATATCGAGGCCACAGTCCCCAGAATCAGAGAGAGACATTTTTGGA GCCAGCTGA |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:6250 |
Chromosome Location | 1 |
Locus | Not Available |
References |
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