Lysine-specific demethylase 4B

NameLysine-specific demethylase 4B
Synonyms
  • 1.14.11.-
  • JHDM3B
  • JmjC domain-containing histone demethylation protein 3B
  • JMJD2B
  • Jumonji domain-containing protein 2B
  • KIAA0876
Gene NameKDM4B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037294|Lysine-specific demethylase 4B
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY
DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER
KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR
HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY
GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA
SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE
EEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW
LPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF
NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF
SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQW
KNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS
RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN
EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDI
SAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDN
LYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKR
GDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVA
FVESLLQVQGRPGAPF
Number of residues1096
Molecular Weight121895.515
Theoretical pINot Available
GO Classification
Functions
  • dioxygenase activity
  • zinc ion binding
Processes
  • chromatin modification
  • chromatin organization
  • DNA repair
  • double-strand break repair
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
Components
  • cytoplasm
  • nucleus
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionHistone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO94953
UniProtKB Entry NameKDM4B_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013963|Lysine-specific demethylase 4B (KDM4B)
ATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCA
ACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCC
CACCGGGCGGGCCTGGCCAAGATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTAT
GATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCG
GGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGC
CTGGCCAACAGCGAGAAGTACTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGC
AAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCT
TTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATG
GTGGAGCGCGAGTGCGGCACCATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGC
ATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTAC
CTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTG
GAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGG
CATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGG
ATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTC
AATCACGGGTTCAACTGCGCAGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTAC
GGCAAAGTGGCCACTCAGTGCACGTGCCGGAAGGACATGGTCAAGATCTCCATGGACGTG
TTCGTGCGCATCCTGCAGCCCGAGCGCTACGAGCTGTGGAAGCAGGGCAAGGACCTCACG
GTGCTGGACCACACGCGGCCCACGGCGCTCACCAGCCCCGAGCTGAGCTCCTGGAGTGCA
TCCCGGGCCTCGCTGAAGGCCAAGCTCCTCCGCAGGTCTCACCGGAAACGGAGCCAGCCC
AAGAAGCCGAAGCCCGAAGACCCCAAGTTCCCTGGGGAGGGTACGGCTGGGGCAGCGCTC
CTAGAGGAGGCTGGGGGCAGCGTGAAGGAGGAGGCTGGGCCGGAGGTTGACCCCGAGGAG
GAGGAGGAGGAGCCGCAGCCACTGCCACACGGCCGGGAGGCCGAGGGCGCAGAAGAGGAC
GGGAGGGGCAAGCTGCGGCCAACCAAGGCCAAGAGCGAGCGGAAGAAGAAGAGCTTCGGC
CTGCTGCCCCCACAGCTGCCGCCCCCGCCTGCTCACTTCCCCTCAGAGGAGGCGCTGTGG
CTGCCATCCCCACTGGAGCCCCCGGTGCTGGGCCCAGGCCCTGCAGCCATGGAGGAGAGC
CCCCTGCCGGCACCCCTTAATGTCGTGCCCCCTGAGGTGCCCAGTGAGGAGCTAGAGGCC
AAGCCTCGGCCCATCATCCCCATGCTGTACGTGGTGCCGCGGCCGGGCAAGGCAGCCTTC
AACCAGGAGCACGTGTCCTGCCAGCAGGCCTTTGAGCACTTTGCCCAGAAGGGTCCGACC
TGGAAGGAACCAGTTTCCCCCATGGAGCTGACGGGGCCAGAGGACGGTGCAGCCAGCAGT
GGGGCAGGTCGCATGGAGACCAAAGCCCGGGCCGGAGAGGGGCAGGCACCGTCCACATTT
TCCAAATTGAAGATGGAGATCAAGAAGAGCCGGCGCCATCCCCTGGGCCGGCCGCCCACC
CGGTCCCCACTGTCGGTGGTGAAGCAGGAGGCCTCAAGTGACGAGGAGGCATCCCCTTTC
TCCGGGGAGGAAGATGTGAGTGACCCGGACGCCTTGAGGCCGCTGCTGTCTCTGCAGTGG
AAGAACAGGGCGGCCAGCTTCCAGGCCGAGAGGAAGTTCAACGCAGCGGCTGCGCGCACG
GAGCCCTACTGCGCCATCTGCACGCTCTTCTACCCCTACTGCCAGGCCCTACAGACTGAG
AAGGAGGCACCCATAGCCTCCCTCGGAGAGGGCTGCCCGGCCACATTACCCTCCAAAAGC
CGTCAGAAGACCCGACCGCTCATCCCTGAGATGTGCTTCACCTCTGGCGGTGAGAACACG
GAGCCGCTGCCTGCCAACTCCTACATCGGCGACGACGGGACCAGCCCCCTGATCGCCTGC
GGCAAGTGCTGCCTGCAGGTCCATGCCAGTTGCTATGGCATCCGTCCCGAGCTGGTCAAT
GAAGGCTGGACGTGTTCCCGGTGCGCGGCCCACGCCTGGACTGCGGAGTGCTGCCTGTGC
AACCTGCGAGGAGGTGCGCTGCAGATGACCACCGATAGGAGGTGGATCCACGTGATCTGT
GCCATCGCAGTCCCCGAGGCGCGCTTCCTGAACGTGATTGAGCGCCACCCTGTGGACATC
AGCGCCATCCCCGAGCAGCGGTGGAAGCTGAAATGCGTGTACTGCCGGAAGCGGATGAAG
AAGGTGTCAGGTGCCTGTATCCAGTGCTCCTACGAGCACTGCTCCACGTCCTTCCACGTG
ACCTGCGCCCACGCCGCAGGCGTGCTCATGGAGCCGGACGACTGGCCCTATGTGGTCTCC
ATCACCTGCCTCAAGCACAAGTCGGGGGGTCACGCTGTCCAACTCCTGAGGGCCGTGTCC
CTAGGCCAGGTGGTCATCACCAAGAACCGCAACGGGCTGTACTACCGCTGTCGCGTCATC
GGTGCCGCCTCGCAGACCTGCTACGAAGTGAACTTCGACGATGGCTCCTACAGCGACAAC
CTGTACCCTGAGAGCATCACGAGTAGGGACTGTGTCCAGCTGGGACCCCCTTCCGAGGGG
GAGCTGGTGGAGCTCCGGTGGACTGACGGCAACCTCTACAAGGCCAAGTTCATCTCCTCC
GTCACCAGCCACATCTACCAGGTGGAGTTTGAGGACGGGTCCCAGCTGACGGTGAAGCGT
GGGGACATCTTCACCCTGGAGGAGGAGCTGCCCAAGAGGGTCCGCTCTCGGCTGTCACTG
AGCACGGGGGCACCGCAGGAGCCCGCCTTCTCGGGGGAGGAGGCCAAGGCCGCCAAGCGC
CCGCGTGTGGGCACCCCGCTTGCCACGGAGGACTCCGGGCGGAGCCAGGACTACGTGGCC
TTCGTGGAGAGCCTCCTGCAGGTGCAGGGCCGGCCCGGAGCCCCCTTCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:29136
Chromosome Location19
LocusNot Available
References
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