T3DB: Lysine-specific demethylase 4B

Name	Lysine-specific demethylase 4B
Synonyms	1.14.11.- JHDM3B JmjC domain-containing histone demethylation protein 3B JMJD2B Jumonji domain-containing protein 2B KIAA0876
Gene Name	KDM4B
Organism	Human
Amino acid sequence	>lcl\|BSEQ0037294\|Lysine-specific demethylase 4B MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE EEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW LPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQW KNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKS RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDI SAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDN LYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKR GDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVA FVESLLQVQGRPGAPF
Number of residues	1096
Molecular Weight	121895.515
Theoretical pI	Not Available
GO Classification	Functions dioxygenase activity zinc ion binding Processes DNA repair double-strand break repair regulation of transcription, DNA-templated transcription, DNA-templated chromatin modification chromatin organization Components nucleus nucleoplasm cytoplasm
General Function	Zinc ion binding
Specific Function	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Pfam Domain Function	JmjC (PF02373 ) JmjN (PF02375 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	O94953
UniProtKB Entry Name	KDM4B_HUMAN
Cellular Location	Nucleus
Gene sequence	>lcl\|BSEQ0013963\|Lysine-specific demethylase 4B (KDM4B) ATGGGGTCTGAGGACCACGGCGCCCAGAACCCCAGCTGTAAAATCATGACGTTTCGCCCA ACCATGGAAGAATTTAAAGACTTCAACAAATACGTGGCCTACATAGAGTCGCAGGGAGCC CACCGGGCGGGCCTGGCCAAGATCATCCCCCCGAAGGAGTGGAAGCCGCGGCAGACGTAT GATGACATCGACGACGTGGTGATCCCGGCGCCCATCCAGCAGGTGGTGACGGGCCAGTCG GGCCTCTTCACGCAGTACAATATCCAGAAGAAGGCCATGACAGTGGGCGAGTACCGCCGC CTGGCCAACAGCGAGAAGTACTGTACCCCGCGGCACCAGGACTTTGATGACCTTGAACGC AAATACTGGAAGAACCTCACCTTTGTCTCCCCGATCTACGGGGCTGACATCAGCGGCTCT TTGTATGATGACGACGTGGCCCAGTGGAACATCGGGAGCCTCCGGACCATCCTGGACATG GTGGAGCGCGAGTGCGGCACCATCATCGAGGGCGTGAACACGCCCTACCTGTACTTCGGC ATGTGGAAGACCACCTTCGCCTGGCACACCGAGGACATGGACCTGTACAGCATCAACTAC CTGCACTTTGGGGAGCCTAAGTCCTGGTACGCCATCCCACCAGAGCACGGCAAGCGCCTG GAGCGGCTGGCCATCGGCTTCTTCCCCGGGAGCTCGCAGGGCTGCGACGCCTTCCTGCGG CATAAGATGACCCTCATCTCGCCCATCATCCTGAAGAAGTACGGGATCCCCTTCAGCCGG ATCACGCAGGAGGCCGGGGAATTCATGATCACATTTCCCTACGGCTACCACGCCGGCTTC AATCACGGGTTCAACTGCGCAGAATCTACCAACTTCGCCACCCTGCGGTGGATTGACTAC GGCAAAGTGGCCACTCAGTGCACGTGCCGGAAGGACATGGTCAAGATCTCCATGGACGTG TTCGTGCGCATCCTGCAGCCCGAGCGCTACGAGCTGTGGAAGCAGGGCAAGGACCTCACG GTGCTGGACCACACGCGGCCCACGGCGCTCACCAGCCCCGAGCTGAGCTCCTGGAGTGCA TCCCGGGCCTCGCTGAAGGCCAAGCTCCTCCGCAGGTCTCACCGGAAACGGAGCCAGCCC AAGAAGCCGAAGCCCGAAGACCCCAAGTTCCCTGGGGAGGGTACGGCTGGGGCAGCGCTC CTAGAGGAGGCTGGGGGCAGCGTGAAGGAGGAGGCTGGGCCGGAGGTTGACCCCGAGGAG GAGGAGGAGGAGCCGCAGCCACTGCCACACGGCCGGGAGGCCGAGGGCGCAGAAGAGGAC GGGAGGGGCAAGCTGCGGCCAACCAAGGCCAAGAGCGAGCGGAAGAAGAAGAGCTTCGGC CTGCTGCCCCCACAGCTGCCGCCCCCGCCTGCTCACTTCCCCTCAGAGGAGGCGCTGTGG CTGCCATCCCCACTGGAGCCCCCGGTGCTGGGCCCAGGCCCTGCAGCCATGGAGGAGAGC CCCCTGCCGGCACCCCTTAATGTCGTGCCCCCTGAGGTGCCCAGTGAGGAGCTAGAGGCC AAGCCTCGGCCCATCATCCCCATGCTGTACGTGGTGCCGCGGCCGGGCAAGGCAGCCTTC AACCAGGAGCACGTGTCCTGCCAGCAGGCCTTTGAGCACTTTGCCCAGAAGGGTCCGACC TGGAAGGAACCAGTTTCCCCCATGGAGCTGACGGGGCCAGAGGACGGTGCAGCCAGCAGT GGGGCAGGTCGCATGGAGACCAAAGCCCGGGCCGGAGAGGGGCAGGCACCGTCCACATTT TCCAAATTGAAGATGGAGATCAAGAAGAGCCGGCGCCATCCCCTGGGCCGGCCGCCCACC CGGTCCCCACTGTCGGTGGTGAAGCAGGAGGCCTCAAGTGACGAGGAGGCATCCCCTTTC TCCGGGGAGGAAGATGTGAGTGACCCGGACGCCTTGAGGCCGCTGCTGTCTCTGCAGTGG AAGAACAGGGCGGCCAGCTTCCAGGCCGAGAGGAAGTTCAACGCAGCGGCTGCGCGCACG GAGCCCTACTGCGCCATCTGCACGCTCTTCTACCCCTACTGCCAGGCCCTACAGACTGAG AAGGAGGCACCCATAGCCTCCCTCGGAGAGGGCTGCCCGGCCACATTACCCTCCAAAAGC CGTCAGAAGACCCGACCGCTCATCCCTGAGATGTGCTTCACCTCTGGCGGTGAGAACACG GAGCCGCTGCCTGCCAACTCCTACATCGGCGACGACGGGACCAGCCCCCTGATCGCCTGC GGCAAGTGCTGCCTGCAGGTCCATGCCAGTTGCTATGGCATCCGTCCCGAGCTGGTCAAT GAAGGCTGGACGTGTTCCCGGTGCGCGGCCCACGCCTGGACTGCGGAGTGCTGCCTGTGC AACCTGCGAGGAGGTGCGCTGCAGATGACCACCGATAGGAGGTGGATCCACGTGATCTGT GCCATCGCAGTCCCCGAGGCGCGCTTCCTGAACGTGATTGAGCGCCACCCTGTGGACATC AGCGCCATCCCCGAGCAGCGGTGGAAGCTGAAATGCGTGTACTGCCGGAAGCGGATGAAG AAGGTGTCAGGTGCCTGTATCCAGTGCTCCTACGAGCACTGCTCCACGTCCTTCCACGTG ACCTGCGCCCACGCCGCAGGCGTGCTCATGGAGCCGGACGACTGGCCCTATGTGGTCTCC ATCACCTGCCTCAAGCACAAGTCGGGGGGTCACGCTGTCCAACTCCTGAGGGCCGTGTCC CTAGGCCAGGTGGTCATCACCAAGAACCGCAACGGGCTGTACTACCGCTGTCGCGTCATC GGTGCCGCCTCGCAGACCTGCTACGAAGTGAACTTCGACGATGGCTCCTACAGCGACAAC CTGTACCCTGAGAGCATCACGAGTAGGGACTGTGTCCAGCTGGGACCCCCTTCCGAGGGG GAGCTGGTGGAGCTCCGGTGGACTGACGGCAACCTCTACAAGGCCAAGTTCATCTCCTCC GTCACCAGCCACATCTACCAGGTGGAGTTTGAGGACGGGTCCCAGCTGACGGTGAAGCGT GGGGACATCTTCACCCTGGAGGAGGAGCTGCCCAAGAGGGTCCGCTCTCGGCTGTCACTG AGCACGGGGGCACCGCAGGAGCCCGCCTTCTCGGGGGAGGAGGCCAAGGCCGCCAAGCGC CCGCGTGTGGGCACCCCGCTTGCCACGGAGGACTCCGGGCGGAGCCAGGACTACGTGGCC TTCGTGGAGAGCCTCCTGCAGGTGCAGGGCCGGCCCGGAGCCCCCTTCTAG
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:29136
Chromosome Location	19
Locus	Not Available
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