T3DB: Adhesion G protein-coupled receptor L1

Name	Adhesion G protein-coupled receptor L1
Synonyms	Calcium-independent alpha-latrotoxin receptor 1 CIRL-1 KIAA0821 Latrophilin-1 LEC2 Lectomedin-2 LPHN1
Gene Name	ADGRL1
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009042\|Adhesion G protein-coupled receptor L1 MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVEN ANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYK YLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWI PYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRT RIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTL RFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSL TFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPT PLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPSTRRPPAPNLHVSPELFC EPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQV AQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAG KNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAF LLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSR NGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVF LMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTN FAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLC INLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEY SRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLV FLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAY LFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTR YYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPY NTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFP PGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEE EAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPG RDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGY YQVRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL
Number of residues	1474
Molecular Weight	162715.375
Theoretical pI	Not Available
GO Classification	Functions G-protein coupled receptor activity latrotoxin receptor activity carbohydrate binding cell adhesion molecule binding Processes positive regulation of synapse assembly calcium-mediated signaling using intracellular calcium source synaptic vesicle exocytosis positive regulation of synapse maturation G-protein coupled receptor signaling pathway cell surface receptor signaling pathway heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Components intracellular plasma membrane cell junction integral component of membrane synapse neuron projection growth cone presynaptic membrane axon
General Function	Latrotoxin receptor activity
Specific Function	Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity).
Pfam Domain Function	7tm_2 (PF00002 ) HRM (PF02793 ) GPS (PF01825 ) GAIN (PF16489 ) Gal_Lectin (PF02140 ) Latrophilin (PF02354 ) OLF (PF02191 )
Transmembrane Regions	859-879 894-914 921-941 965-985 1003-1023 1051-1071 1076-1096
GenBank Protein ID	Not Available
UniProtKB ID	O94910
UniProtKB Entry Name	AGRL1_HUMAN
Cellular Location	Cell membrane
Gene sequence	>lcl\|BSEQ0021426\|Adhesion G protein-coupled receptor L1 (ADGRL1) ATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCG GCCACCCAAGGCCTGAGCCGGGCCGGGCTCCCGTTCGGGCTGATGCGCCGGGAGCTGGCG TGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAAT GCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAAT GTGCAGTGCTACCTGCCGGACGCCTTCAAGATCATGTCACAGAGGTGTAACAACCGCACC CAGTGCGTGGTGGTCGCCGGCTCGGATGCCTTTCCTGACCCCTGTCCTGGGACCTACAAG TACCTGGAGGTGCAGTACGACTGTGTCCCCTACAAAGTGGAGCAGAAAGTCTTCGTGTGC CCAGGGACCCTGCAGAAGGTGCTGGAGCCCACCTCGACACACGAGTCAGAGCACCAGTCT GGCGCATGGTGCAAGGACCCGCTGCAGGCGGGTGACCGCATCTACGTGATGCCCTGGATC CCCTACCGCACGGACACACTGACTGAGTATGCCTCGTGGGAGGACTACGTGGCCGCCCGC CACACCACCACCTACCGCCTGCCCAACCGCGTGGATGGCACAGGCTTTGTGGTCTACGAT GGTGCCGTCTTCTACAACAAGGAGCGCACGCGCAACATCGTCAAGTATGACCTACGGACG CGCATCAAGAGCGGGGAGACGGTCATCAATACCGCCAACTACCATGACACCTCGCCCTAC CGCTGGGGCGGAAAGACCGACATTGACCTGGCGGTGGACGAGAACGGGCTGTGGGTCATC TACGCCACTGAGGGCAACAACGGGCGGCTGGTGGTGAGCCAGCTGAACCCCTACACACTG CGCTTTGAGGGCACGTGGGAGACGGGTTACGACAAGCGCTCGGCATCCAACGCCTTCATG GTGTGTGGGGTCCTGTACGTCCTGCGTTCCGTGTACGTGGATGATGACAGCGAGGCGGCT GGCAACCGCGTGGACTATGCCTTCAACACCAATGCCAACCGCGAGGAGCCTGTCAGCCTC ACCTTCCCCAACCCCTACCAGTTCATCTCCTCCGTTGACTACAACCCTCGCGACAACCAG CTGTACGTCTGGAACAACTATTTCGTGGTGCGCTACAGCCTGGAGTTCGGGCCGCCCGAC CCCAGTGCTGGCCCAGCCACTTCCCCACCCCTCAGCACGACCACCACAGCCAGGCCCACG CCCCTCACCAGCACAGCCTCGCCCGCAGCCACCACCCCGCTCCGCCGGGCACCCCTCACC ACGCACCCAGTGGGTGCCATCAACCAGCTGGGACCTGATCTGCCTCCAGCCACAGCCCCA GTCCCCAGCACCCGGCGGCCCCCAGCCCCGAATCTACACGTGTCCCCTGAGCTCTTCTGC GAGCCCCGAGAGGTACGGCGGGTCCAGTGGCCGGCCACCCAGCAGGGCATGCTGGTGGAG AGGCCCTGCCCCAAGGGGACTCGAGGAATTGCCTCCTTCCAGTGTCTACCAGCCTTGGGG CTCTGGAACCCCCGGGGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTG GCCCAGAAGATCAAGAGTGGGGAGAACGCGGCCAACATCGCCAGCGAGCTGGCCCGACAC ACCCGGGGCTCCATCTACGCGGGGGACGTCTCCTCCTCTGTGAAGCTGATGGAGCAGCTG CTGGACATCCTGGATGCCCAGCTGCAGGCCCTGCGGCCCATCGAGCGCGAGTCAGCCGGC AAGAACTACAACAAGATGCACAAGCGAGAGAGAACTTGTAAGGATTATATCAAGGCCGTG GTGGAGACAGTGGACAATCTGCTCCGGCCAGAAGCTCTGGAGTCCTGGAAGGACATGAAT GCCACGGAGCAGGTGCACACGGCCACCATGCTCCTCGACGTCCTGGAGGAGGGCGCCTTC CTGCTGGCCGACAATGTCAGGGAGCCTGCCCGCTTCCTGGCTGCCAAGGAGAACGTGGTC CTGGAGGTCACAGTCCTGAACACAGAGGGCCAGGTGCAGGAGCTGGTGTTCCCCCAGGAG GAGTACCCGAGAAAGAACTCCATCCAGCTGTCTGCCAAAACCATCAAGCAGAACAGCCGC AATGGGGTGGTCAAAGTTGTCTTCATCCTCTACAACAACCTGGGCCTCTTCCTGTCCACG GAGAATGCCACAGTGAAGCTGGCCGGCGAAGCAGGCCCGGGTGGCCCTGGGGGCGCCTCT CTAGTGGTGAACTCACAGGTCATCGCAGCATCCATCAACAAGGAGTCCAGCCGCGTCTTC CTCATGGACCCTGTCATCTTCACCGTGGCCCACCTGGAGGACAAGAACCACTTCAATGCT AACTGCTCCTTCTGGAACTACTCGGAGCGTTCCATGCTGGGCTACTGGTCGACCCAAGGC TGCCGCCTGGTGGAGTCCAACAAGACCCATACCACGTGTGCCTGCAGCCACCTCACCAAC TTCGCTGTGCTCATGGCTCACCGTGAGATCTACCAGGGCCGCATCAACGAGCTGCTGCTG TCGGTCATCACCTGGGTGGGCATTGTGATCTCCCTGGTCTGCTTGGCCATCTGCATCTCC ACCTTCTGCTTCCTGCGGGGGCTGCAGACCGACCGCAACACCATCCACAAGAACCTGTGC ATCAACCTCTTCCTGGCTGAGCTGCTCTTCCTGGTCGGGATCGACAAGACTCAGTATGAG ATTGCCTGCCCCATCTTCGCCGGCCTGCTGCACTATTTCTTCCTGGCTGCCTTCTCCTGG CTGTGCCTGGAGGGCGTGCACCTCTACCTGCTACTAGTGGAGGTGTTTGAGAGCGAGTAT TCCCGCACCAAGTACTACTACCTGGGTGGCTACTGCTTCCCGGCCCTGGTGGTGGGCATC GCGGCTGCCATTGACTACCGCAGCTACGGCACCGAGAAGGCCTGCTGGCTCCGAGTGGAC AATTACTTCATCTGGAGTTTCATCGGGCCAGTCTCCTTCGTTATCGTGGTCAACCTGGTG TTCCTCATGGTGACCCTGCACAAGATGATCCGAAGCTCATCTGTGCTCAAGCCCGACTCC AGCCGCCTGGACAACATTAAATCCTGGGCGCTGGGGGCCATCGCGCTGCTGTTCCTGCTG GGCCTCACCTGGGCTTTCGGCCTCCTCTTCATCAACAAGGAGTCGGTGGTCATGGCCTAT CTCTTCACCACCTTCAACGCCTTCCAGGGGGTCTTCATCTTCGTCTTTCACTGCGCCTTA CAGAAGAAGGTGCACAAGGAGTACAGCAAGTGCCTGCGTCACTCCTACTGCTGCATCCGC TCCCCACCCGGGGGCACTCACGGATCCCTCAAGACCTCAGCCATGCGAAGCAACACCCGC TACTACACAGGGACCCAGAGCCGAATTCGGAGGATGTGGAATGACACTGTGAGGAAACAG ACGGAGTCCTCCTTCATGGCGGGTGACATCAACAGCACCCCCACCCTGAACCGAGGTACC ATGGGGAACCACCTGCTGACCAACCCCGTGCTGCAGCCCCGTGGGGGCACCAGTCCCTAC AACACCCTCATCGCCGAGTCAGTGGGCTTCAATCCCTCCTCGCCCCCTGTCTTCAACTCC CCAGGGAGCTACCGGGAACCCAAGCACCCCTTGGGAGGCCGGGAAGCCTGTGGCATGGAC ACCCTGCCCCTGAACGGCAACTTCAATAACAGTTACTCCTTGCGAAGTGGGGATTTCCCT CCCGGGGATGGGGGCCCTGAGCCGCCCCGAGGCCGGAACCTAGCCGATGCGGCGGCCTTT GAGAAGATGATCATCTCAGAGCTGGTGCACAACAACCTGCGGGGGAGCAGCAGCGCGGCC AAGGGCCCTCCACCGCCTGAGCCCCCTGTGCCACCTGTGCCAGGGGGCGGGGGCGAGGAA GAGGCGGGCGGGCCCGGGGGTGCTGACCGGGCCGAGATTGAACTTCTCTATAAGGCCCTG GAGGAGCCTCTGCTGCTGCCCCGGGCCCAGTCGGTGCTGTACCAGAGCGATCTGGACGAG TCGGAGAGCTGCACGGCCGAGGACGGCGCCACCAGCCGGCCCCTCTCCTCCCCTCCTGGC CGGGACTCCCTCTATGCCAGCGGGGCCAACCTGCGGGACTCACCCTCCTACCCGGACAGC AGCCCTGAGGGGCCCAGTGAGGCCCTGCCCCCACCCCCTCCCGCACCCCCCGGCCCCCCC GAAATCTACTACACCTCGCGCCCGCCAGCCCTGGTGGCCCGGAATCCCCTGCAGGGCTAC TACCAGGTGCGGCGTCCTAGCCACGAGGGCTACCTGGCAGCCCCAGGCCTTGAGGGGCCA GGGCCCGATGGGGACGGGCAGATGCAGCTGGTCACCAGTCTCTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:20973
Chromosome Location	19
Locus	Not Available
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