NameRetinal dehydrogenase 2
Synonyms
  • 1.2.1.36
  • Aldehyde dehydrogenase family 1 member A2
  • RALDH 2
  • RALDH(II)
  • RALDH2
  • Retinaldehyde-specific dehydrogenase type 2
Gene NameALDH1A2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001024|Retinal dehydrogenase 2
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP
GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
Number of residues518
Molecular Weight56723.495
Theoretical pI5.84
GO Classification
Functions
  • 3-chloroallyl aldehyde dehydrogenase activity
  • retinal dehydrogenase activity
  • retinal binding
  • aldehyde dehydrogenase (NAD) activity
Processes
  • retinoic acid metabolic process
  • embryonic digestive tract development
  • face development
  • liver development
  • retinal metabolic process
  • positive regulation of gene expression
  • heart morphogenesis
  • response to vitamin A
  • morphogenesis of embryonic epithelium
  • response to cytokine
  • positive regulation of apoptotic process
  • embryonic forelimb morphogenesis
  • vitamin A metabolic process
  • blood vessel development
  • proximal/distal pattern formation
  • midgut development
  • cellular response to retinoic acid
  • 9-cis-retinoic acid biosynthetic process
  • retinol metabolic process
  • response to estradiol
  • neuron differentiation
  • pituitary gland development
  • lung development
  • anterior/posterior pattern specification
  • cardiac muscle tissue development
  • negative regulation of cell proliferation
  • hindbrain development
  • pancreas development
  • positive regulation of cell proliferation
  • determination of bilateral symmetry
  • retinoic acid receptor signaling pathway
  • kidney development
  • embryonic camera-type eye development
  • regulation of endothelial cell proliferation
  • ureter maturation
  • neural crest cell development
  • neural tube development
Components
  • cytoplasm
  • cytosol
  • perinuclear region of cytoplasm
General FunctionRetinal dehydrogenase activity
Specific FunctionRecognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID3970842
UniProtKB IDO94788
UniProtKB Entry NameAL1A2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016114|Retinal dehydrogenase 2 (ALDH1A2)
ATGAAGAATCAGTGTGAGACTGTTTGGTTAAAATCCCCAATAAAACTGAAACTGATCTTT
ATAAACAACGAGTGGCAGAACTCAGAGAGTGGGAGAGTGTTCCCTGTCTATAATCCAGCC
ACAGGAGAACAGGTGTGTGAAGTTCAAGAAGCAGACAAGGCAGATATAGACAAAGCAGTG
CAGGCAGCCCGCCTGGCTTTCTCTCTTGGTTCAGTGTGGAGAAGGATGGATGCTTCAGAA
AGGGGACGTCTGTTGGATAAGCTTGCAGACTTGGTGGAACGGGACAGGGCAGTTCTTGCA
ACCATGGAATCCCTAAATGGTGGCAAACCATTCCTGCAAGCTTTTTATGTGGATTTGCAG
GGCGTCATCAAAACCTTTCGATATTACGCAGGCTGGGCTGATAAAATTCATGGGATGACC
ATTCCTGTAGATGGAGACTATTTTACCTTTACAAGACATGAACCCATTGGAGTGTGTGGA
CAGATCATCCCATGGAACTTCCCCCTGCTGATGTTTGCCTGGAAAATAGCTCCAGCTTTG
TGCTGTGGCAATACAGTAGTTATTAAGCCAGCAGAGCAAACACCACTCAGTGCACTCTAC
ATGGGAGCCCTCATCAAGGAGGCTGGCTTTCCTCCCGGGGTCATCAATATTTTGCCAGGA
TATGGGCCAACGGCTGGGGCAGCAATAGCTTCTCACATTGGCATAGACAAGATTGCATTC
ACAGGGTCTACTGAGGTTGGAAAGCTTATCCAAGAAGCAGCTGGAAGAAGTAATTTGAAG
AGAGTAACTCTGGAACTTGGAGGCAAAAGTCCTAATATTATTTTTGCTGATGCTGACTTG
GACTATGCTGTGGAGCAGGCCCACCAGGGTGTGTTCTTCAATCAAGGTCAGTGCTGCACT
GCAGGCTCTCGCATCTTCGTGGAGGAGTCCATCTATGAGGAGTTTGTGAGAAGAAGCGTG
GAGCGGGCCAAGAGGCGCGTAGTGGGGAGTCCCTTTGACCCCACCACTGAGCAGGGTCCC
CAGATTGATAAGAAACAGTACAACAAGATCTTGGAACTCATCCAGAGTGGTGTGGCTGAG
GGCGCCAAGCTGGAATGTGGAGGCAAAGGACTGGGCCGAAAGGGGTTTTTCATTGAGCCC
ACAGTGTTTTCCAACGTCACTGATGATATGCGGATTGCCAAGGAGGAGATCTTTGGCCCT
GTTCAGGAAATTTTGAGATTTAAGACGATGGATGAAGTTATCGAAAGAGCCAATAACTCA
GACTTTGGACTCGTAGCAGCTGTCTTTACTAATGACATCAACAAGGCCCTCACAGTGTCT
TCTGCAATGCAAGCTGGGACTGTTTGGATCAATTGTTACAATGCCTTAAATGCCCAGAGC
CCCTTTGGGGGATTCAAGATGTCTGGAAATGGGAGAGAAATGGGAGAATTTGGCTTGCGG
GAGTACTCAGAAGTTAAGACGGTGACAGTAAAGATCCCCCAGAAGAACTCCTAA
GenBank Gene IDAB015226
GeneCard IDNot Available
GenAtlas IDALDH1A2
HGNC IDHGNC:15472
Chromosome Location15
Locus15q22.1
References
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