Serine/threonine-protein kinase 17B

NameSerine/threonine-protein kinase 17B
Synonyms
  • 2.7.11.1
  • DAP kinase-related apoptosis-inducing protein kinase 2
  • DRAK2
Gene NameSTK17B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013020|Serine/threonine-protein kinase 17B
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYA
AKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFS
LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDF
GMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN
QETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFEN
LFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSL
PNPHELVSDLLC
Number of residues372
Molecular Weight42343.595
Theoretical pI4.91
GO Classification
Functions
  • protein serine/threonine kinase activity
  • ATP binding
  • protein kinase activity
Processes
  • apoptotic process
  • protein phosphorylation
  • intracellular signal transduction
  • protein autophosphorylation
  • positive regulation of fibroblast apoptotic process
Components
  • nucleus
  • plasma membrane
  • actin cytoskeleton
  • endoplasmic reticulum-Golgi intermediate compartment
General FunctionProtein serine/threonine kinase activity
Specific FunctionPhosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID3834356
UniProtKB IDO94768
UniProtKB Entry NameST17B_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013021|Serine/threonine-protein kinase 17B (STK17B)
ATGTCGAGGAGGAGATTTGATTGCCGAAGTATTTCAGGCCTACTAACTACAACTCCTCAA
ATTCCAATAAAAATGGAAAACTTTAATAATTTCTATATACTTACATCTAAAGAGCTAGGG
AGAGGAAAATTTGCTGTGGTTAGACAATGTATATCAAAATCTACTGGCCAAGAATATGCT
GCAAAATTTCTAAAAAAGAGAAGAAGAGGACAGGATTGTCGAGCAGAAATTTTACACGAG
ATTGCTGTGCTTGAATTGGCAAAGTCTTGTCCCCGTGTTATTAATCTTCATGAGGTCTAT
GAAAATACAAGTGAAATCATTTTGATATTGGAATATGCTGCAGGTGGAGAAATTTTCAGC
CTGTGTTTACCTGAGTTGGCTGAAATGGTTTCTGAAAATGATGTTATCAGACTCATTAAA
CAAATACTTGAAGGAGTTTATTATCTACATCAGAATAACATTGTACACCTTGATTTAAAG
CCACAGAATATATTACTGAGCAGCATATACCCTCTCGGGGACATTAAAATAGTAGATTTT
GGAATGTCTCGAAAAATAGGGCATGCGTGTGAACTTCGGGAAATCATGGGAACACCAGAA
TATTTAGCTCCAGAAATCCTGAACTATGATCCCATTACCACAGCAACAGATATGTGGAAT
ATTGGTATAATAGCATATATGTTGTTAACTCACACATCACCATTTGTGGGAGAAGATAAT
CAAGAAACATACCTCAATATTTCTCAAGTTAATGTAGATTATTCGGAAGAAACTTTTTCA
TCAGTTTCACAGCTGGCCACAGACTTTATTCAGAGCCTTTTAGTAAAAAATCCAGAGAAA
AGACCAACAGCAGAGATATGCCTTTCTCATTCTTGGCTACAGCAGTGGGACTTTGAAAAC
TTGTTTCACCCTGAAGAAACTTCCAGTTCCTCTCAAACTCAGGATCATTCTGTAAGGTCC
TCTGAAGACAAGACTTCTAAATCCTCCTGTAATGGAACCTGTGGTGATAGAGAAGACAAA
GAGAATATCCCAGAGGATAGCAGCATGGTTTCCAAAAGATTTCGTTTCGATGACTCATTA
CCCAATCCCCATGAACTTGTTTCAGATTTGCTCTGTTAG
GenBank Gene IDAB011421
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11396
Chromosome Location2
Locus2q32.3
References
  1. Sanjo H, Kawai T, Akira S: DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem. 1998 Oct 30;273(44):29066-71. 9786912
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  3. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. 19369195
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. 19690332
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