N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

NameN(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms
  • 3.5.3.18
  • DDAH
  • DDAH-1
  • DDAHI
  • Dimethylargininase-1
Gene NameDDAH1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037071|N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGL
QVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMK
DENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSM
AGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPE
EYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
Number of residues285
Molecular Weight31121.5
Theoretical pI5.61
GO Classification
Functions
  • dimethylargininase activity
  • catalytic activity
  • amino acid binding
  • metal ion binding
Processes
  • positive regulation of angiogenesis
  • arginine catabolic process
  • nitric oxide mediated signal transduction
  • nitric oxide metabolic process
  • regulation of nitric-oxide synthase activity
  • positive regulation of nitric oxide biosynthetic process
  • regulation of systemic arterial blood pressure
  • citrulline metabolic process
  • small molecule metabolic process
Components
  • extracellular exosome
  • mitochondrion
  • cytosol
General FunctionMetal ion binding
Specific FunctionHydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID4160666
UniProtKB IDO94760
UniProtKB Entry NameDDAH1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0021273|N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)
ATGATGAAAGAAGCATTAGAAAAACTTCAGCTCAATATAGTAGAGATGAAAGATGAAAAT
GCAACTTTAGATGGCGGAGATGTTTTATTCACAGGCAGAGAATTTTTTGTGGGCCTTTCC
AAAAGGACAAATCAACGAGGTGCTGAAATCTTGGCTGATACTTTTAAGGACTATGCAGTC
TCCACAGTGCCAGTGGCAGATGGGTTGCATTTGAAGAGTTTCTGCAGCATGGCTGGGCCT
AACCTGATCGCAATTGGGTCTAGTGAATCTGCACAGAAGGCCCTTAAGATCATGCAACAG
ATGAGTGACCACCGCTACGACAAACTCACTGTGCCTGATGACATAGCAGCAAACTGTATA
TATCTAAATATCCCCAACAAAGGGCACGTCTTGCTGCACCGAACCCCGGAAGAGTATCCA
GAAAGTGCAAAGGTTTATGAGAAACTGAAGGACCATATGCTGATCCCCGTGAGCATGTCT
GAACTGGAAAAGGTGGATGGGCTGCTCACCTGCTGCTCAGTTTTAATTAACAAGAAAGTA
GACTCCTGA
GenBank Gene IDAB001915
GeneCard IDNot Available
GenAtlas IDDDAH1
HGNC IDHGNC:2715
Chromosome Location1
Locus1p22
References
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  2. Leiper JM, Santa Maria J, Chubb A, MacAllister RJ, Charles IG, Whitley GS, Vallance P: Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochem J. 1999 Oct 1;343 Pt 1:209-14. 10493931
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