NameShort-chain dehydrogenase/reductase 3
Synonyms
  • 1.1.1.300
  • DD83.1
  • RDH17
  • Retinal short-chain dehydrogenase/reductase 1
  • Retinol dehydrogenase 17
  • retSDR1
  • SDR16C1
  • Short chain dehydrogenase/reductase family 16C member 1
Gene NameDHRS3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004554|Short-chain dehydrogenase/reductase 3
MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP
LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG
RT
Number of residues302
Molecular Weight33548.115
Theoretical pI9.08
GO Classification
Functions
  • NADP-retinol dehydrogenase activity
  • nucleotide binding
  • electron carrier activity
  • retinol dehydrogenase activity
Processes
  • negative regulation of retinoic acid receptor signaling pathway
  • outflow tract morphogenesis
  • palate development
  • cardiac septum morphogenesis
  • regulation of ossification
  • visual perception
  • phototransduction, visible light
  • retinoid metabolic process
  • retinol metabolic process
  • bone morphogenesis
Components
  • photoreceptor outer segment membrane
  • endoplasmic reticulum membrane
  • integral component of membrane
General FunctionRetinol dehydrogenase activity
Specific FunctionCatalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
Pfam Domain Function
Transmembrane Regions9-29 170-190 195-215 253-273
GenBank Protein ID3450828
UniProtKB IDO75911
UniProtKB Entry NameDHRS3_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0019271|Short-chain dehydrogenase/reductase 3 (DHRS3)
ATGGTGTGGAAACGGCTGGGCGCGCTGGTGATGTTCCCTCTACAGATGATCTATCTGGTG
GTGAAAGCAGCCGTCGGACTGGTGCTGCCCGCCAAGCTGCGGGACCTGTCGCGGGAGAAC
GTCCTCATCACCGGCGGCGGGAGAGGCATCGGGCGTCAGCTCGCCCGCGAGTTCGCGGAG
CGCGGCGCCAGAAAGATTGTTCTCTGGGGCCGGACTGAGAAATGCCTGAAGGAGACGACG
GAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTCATCTGTGATGTGGGCAACCGG
GAGGAGGTGTACCAGACGGCCAAGGCCGTCCGGGAGAAGGTGGGTGACATCACCATCCTG
GTGAACAATGCCGCCGTGGTCCATGGGAAGAGCCTAATGGACAGTGATGATGATGCCCTC
CTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGGACCACCAAGGCCTTCCTGCCG
CGTATGCTGGAGCTGCAGAATGGCCACATCGTGTGCCTCAACTCCGTGCTGGCACTGTCT
GCCATCCCCGGTGCCATCGACTACTGCACATCCAAAGCGTCAGCCTTCGCCTTCATGGAG
AGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGCGCCACCACAGTGCTGCCCTTC
CACACCAGCACCGAGATGTTCCAGGGCATGAGAGTCAGGTTTCCCAACCTCTTTCCCCCA
CTGAAGCCGGAGACGGTGGCCCGGAGGACAGTGGAAGCTGTGCAGCTCAACCAGGCCCTC
CTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTGAAAAGCATACTTCCACAGGCT
GCACTCGAGGAGATCCACAAATTCTCAGGAACCTACACCTGCATGAACACTTTCAAAGGG
CGGACATAG
GenBank Gene IDAF061741
GeneCard IDNot Available
GenAtlas IDDHRS3
HGNC IDHGNC:17693
Chromosome Location1
Locus1p36.1
References
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