NameCytosolic 10-formyltetrahydrofolate dehydrogenase
Synonyms
  • 1.5.1.6
  • 10-FTHFDH
  • Aldehyde dehydrogenase family 1 member L1
  • FTHFD
Gene NameALDH1L1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001858|Cytosolic 10-formyltetrahydrofolate dehydrogenase
MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR
AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN
WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV
RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ
KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI
LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL
VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM
PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI
SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI
QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ
VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK
SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH
DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP
RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT
RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF
EY
Number of residues902
Molecular Weight98828.505
Theoretical pI5.76
GO Classification
Functions
  • catalytic activity
  • methyltransferase activity
  • hydroxymethyl-, formyl- and related transferase activity
  • formyltetrahydrofolate dehydrogenase activity
  • aldehyde dehydrogenase (NAD) activity
Processes
  • 10-formyltetrahydrofolate catabolic process
  • one-carbon metabolic process
  • biosynthetic process
Components
  • cytoplasm
  • mitochondrion
  • extracellular exosome
General FunctionMethyltransferase activity
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID3560541
UniProtKB IDO75891
UniProtKB Entry NameAL1L1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010656|Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1)
ATGGCAGGTCCTTCCAACCCTCCTGCTACCATGAAGATTGCAGTGATTGGACAGAGCCTG
TTTGGCCAGGAAGTTTACTGCCACCTGAGGAAGGAGGGCCACGAAGTGGTGGGTGTGTTC
ACTGTTCCAGACAAGGATGGAAAGGCCGACCCCCTGGGTCTGGAAGCTGAGAAGGATGGA
GTGCCGGTATTCAAGTACTCCCGGTGGCGTGCAAAAGGACAGGCTTTGCCTGATGTGGTG
GCAAAATACCAGGCTTTGGGGGCCGAGCTCAACGTCCTGCCCTTCTGCAGCCAATTCATC
CCCATGGAGATAATCAGTGCCCCCCGGCATGGCTCCATCATCTATCACCCGTCACTGCTC
CCTAGGCACCGAGGGGCCTCGGCCATCAACTGGACCCTCATTCACGGAGATAAGAAAGGG
GGGTTTTCCATCTTCTGGGCGGATGATGGTCTGGACACCGGAGACCTGCTGCTGCAGAAG
GAGTGTGAGGTGCTCCCGGACGACACCGTGAGCACGCTGTACAACCGCTTCCTCTTCCCT
GAAGGCATCAAAGGGATGGTGCAGGCCGTGAGGCTGATCGCTGAGGGCAAAGCCCCCAGA
CTCCCTCAGCCTGAGGAAGGAGCCACCTATGAGGGGATTCAGAAGAAGGAGACAGCCAAG
ATCAACTGGGACCAGCCGGCAGAGGCCATTCACAACTGGATCCGCGGGAACGACAAGGTG
CCGGGAGCCTGGACAGAGGCCTGTGAACAGAAACTGACATTTTTCAACTCAACGCTGAAC
ACTTCAGGCCTGGTGCCCGAGGGAGACGCTTTGCCCATCCCAGGAGCCCATCGGCCAGGG
GTGGTCACCAAAGCAGGACTCATCCTCTTTGGGAATGATGACAAAATGCTGCTGGTGAAG
AATATTCAGCTGGAGGATGGCAAAATGATCCTGGCCTCGAACTTCTTTAAGGGGGCAGCC
AGCAGTGTCCTTGAGCTGACAGAGGCAGAGCTGGTTACTGCGGAGGCTGTGCGGAGTGTT
TGGCAGCGGATCCTCCCCAAAGTCCTGGAGGTTGAAGACTCCACTGATTTCTTCAAGTCA
GGGGCCGCGTCTGTGGACGTTGTGAGGCTGGTGGAGGAAGTGAAGGAGCTGTGTGATGGC
CTGGAGTTAGAAAATGAAGATGTGTACATGGCATCCACCTTTGGGGACTTCATCCAGCTG
TTAGTGAGGAAGCTGCGAGGGGACGATGAGGAGGGCGAGTGCAGCATTGACTACGTGGAA
ATGGCAGTGAACAAGCGCACTGTCCGCATGCCCCACCAGCTCTTCATTGGGGGGGAGTTC
GTGGATGCCGAGGGCGCCAAGACCTCTGAGACCATCAATCCCACCGATGGAAGTGTCATC
TGCCAGGTATCCCTGGCCCAAGTCACCGACGTCGACAAGGCAGTGGCCGCAGCCAAGGAT
GCCTTTGAGAATGGACGGTGGGGGAAGATCAGTGCGCGGGACCGGGGCCGGCTGATGTAC
AGGTTGGCAGATCTCATGGAGCAGCACCAGGAGGAGCTGGCCACCATTGAGGCCCTGGAT
GCGGGTGCCGTCTACACGCTGGCCCTGAAGACCCACGTGGGCATGTCCATCCAGACCTTC
CGCTACTTTGCTGGCTGGTGTGACAAGATCCAGGGCTCCACCATCCCCATCAACCAGGCC
AGACCCAACCGCAACCTGACCTTGACCAGGAAGGAGCCTGTTGGGGTTTGTGGCATCATC
ATCCCCTGGAACTATCCCCTGATGATGCTGTCCTGGAAGACAGCTGCCTGCCTGGCTGCC
GGGAACACAGTGGTGATCAAGCCTGCTCAGGTGACCCCACTCACAGCCTTGAAGTTTGCA
GAGCTGACATTAAAGGCCGGCATTCCCAAAGGTGTGGTTAACGTCCTCCCAGGATCTGGC
TCCCTGGTCGGCCAGAGACTCTCAGACCATCCTGATGTGAGGAAAATCGGGTTCACAGGC
TCCACAGAGGTGGGCAAGCACATCATGAAAAGCTGTGCCATAAGTAACGTGAAGAAGGTG
TCCCTGGAACTGGGCGGGAAGTCACCCCTCATCATCTTTGCTGACTGTGACCTCAACAAG
GCTGTGCAGATGGGGATGAGTTCTGTTTTCTTCAACAAAGGAGAGAATTGCATTGCAGCA
GGCCGACTCTTTGTGGAGGACTCCATTCATGATGAGTTCGTGCGGAGAGTGGTAGAAGAG
GTGCGGAAGATGAAGGTGGGCAACCCGCTGGACAGGGACACCGACCACGGGCCGCAGAAT
CACCATGCCCACCTTGTGAAGCTGATGGAGTACTGCCAGCATGGCGTGAAGGAAGGGGCC
ACACTGGTCTGCGGCGGGAATCAGGTCCCTCGGCCAGGGTTCTTCTTTGAGCCAACTGTT
TTCACAGACGTGGAAGACCACATGTTCATAGCCAAGGAGGAGTCCTTCGGGCCTGTCATG
ATCATCTCTCGGTTTGCTGATGGGGACTTGGATGCCGTGCTGTCTCGGGCCAATGCCACG
GAATTTGGCCTGGCTTCTGGTGTCTTCACCAGGGACATCAACAAGGCCCTGTATGTCAGT
GACAAGCTCCAGGCAGGCACTGTGTTTGTCAACACGTACAACAAGACCGACGTGGCCGCT
CCCTTCGGAGGATTCAAACAGTCTGGATTTGGCAAAGATCTAGGAGAGGCGGCTCTGAAC
GAGTACCTGCGGGTCAAGACAGTGACCTTCGAATACTGA
GenBank Gene IDAF052732
GeneCard IDNot Available
GenAtlas IDALDH1L1
HGNC IDHGNC:3978
Chromosome Location3
Locus3q21.2
References
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