T3DB: Protein phosphatase 1 regulatory subunit 15A

Name	Protein phosphatase 1 regulatory subunit 15A
Synonyms	GADD34 Growth arrest and DNA damage-inducible protein GADD34 Myeloid differentiation primary response protein MyD116 homolog
Gene Name	PPP1R15A
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009122\|Protein phosphatase 1 regulatory subunit 15A MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGL EGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGE REATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYP PSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERS KGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLK SWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDE DSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSA STPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFR GWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPET PTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQ EELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSS AAAAAALDLSGRRG
Number of residues	674
Molecular Weight	73477.025
Theoretical pI	Not Available
GO Classification	Functions protein phosphatase type 1 regulator activity protein phosphatase 1 binding protein kinase binding protein phosphatase type 1 activator activity Processes peptidyl-serine dephosphorylation regulation of translational initiation by eIF2 alpha dephosphorylation negative regulation of transforming growth factor beta receptor signaling pathway cell cycle arrest negative regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine dephosphorylation cellular response to DNA damage stimulus negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress apoptotic process positive regulation of peptidyl-serine phosphorylation negative regulation of protein dephosphorylation positive regulation of phosphoprotein phosphatase activity negative regulation of PERK-mediated unfolded protein response endoplasmic reticulum unfolded protein response transforming growth factor beta receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation positive regulation of gene expression positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation response to endoplasmic reticulum stress positive regulation of translational initiation in response to stress intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein localization to endoplasmic reticulum positive regulation of transcription from RNA polymerase I promoter regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Components endoplasmic reticulum membrane mitochondrial outer membrane Golgi apparatus protein phosphatase type 1 complex cytosol cytoplasm mitochondrion membrane endoplasmic reticulum
General Function	Protein phosphatase type 1 regulator activity
Specific Function	Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Pfam Domain Function	PP1c_bdg (PF10488 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	O75807
UniProtKB Entry Name	PR15A_HUMAN
Cellular Location	Endoplasmic reticulum membrane
Gene sequence	>lcl\|BSEQ0020851\|Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) ATGGCCCCAGGCCAAGCACCCCATCAGGCTACCCCGTGGAGGGATGCCCACCCTTTCTTC CTCCTGTCCCCAGTGATGGGCCTCCTCAGCCGCGCCTGGAGCCGCCTGAGGGGCCTGGGA CCTCTAGAGCCCTGGCTGGTGGAAGCAGTAAAAGGAGCAGCTCTGGTAGAAGCTGGCCTG GAGGGAGAAGCTAGGACTCCTCTGGCAATCCCCCATACCCCTTGGGGCAGACGCCCTGAA GAGGAGGCTGAAGACAGTGGAGGCCCTGGAGAGGACAGAGAAACACTGGGGCTGAAAACC AGCAGTTCCCTTCCTGAAGCCTGGGGACTTTTGGATGATGATGATGGCATGTATGGTGAG CGAGAGGCAACCAGTGTCCCTAGAGGGCAGGGAAGTCAATTTGCAGATGGCCAGCGTGCT CCCCTGTCTCCCAGCCTTCTGATAAGGACACTGCAAGGTTCTGATAAGAACCCAGGGGAG GAGAAAGCCGAGGAAGAGGGAGTTGCTGAAGAGGAGGGAGTTAACAAGTTCTCTTATCCA CCATCACACCGGGAGTGTTGTCCAGCCGTGGAGGAGGAGGACGATGAAGAAGCTGTAAAG AAAGAAGCTCACAGAACCTCTACTTCTGCCTTGTCTCCAGGATCCAAGCCCAGCACTTGG GTGTCTTGCCCAGGGGAGGAAGAGAATCAAGCCACGGAGGATAAAAGAACAGAAAGAAGT AAAGGAGCCAGGAAGACCTCCGTGTCCCCCCGATCTTCAGGCTCCGACCCCAGGTCCTGG GAGTATCGTTCAGGAGAGGCGTCCGAGGAGAAGGAGGAAAAGGCACACAAAGAAACTGGG AAAGGAGAAGCTGCCCCAGGGCCGCAATCCTCAGCCCCAGCCCAGAGGCCCCAGCTCAAG TCCTGGTGGTGCCAACCCAGTGATGAAGAGGAGGGTGAGGTCAAGGCTTTGGGGGCAGCT GAGAAGGATGGAGAAGCTGAGTGTCCTCCCTGCATCCCCCCACCAAGTGCCTTCCTGAAG GCCTGGGTGTATTGGCCAGGAGAGGACACAGAGGAAGAGGAAGATGAGGAAGAAGATGAG GACAGTGACTCTGGATCAGATGAGGAAGAGGGAGAAGCTGAGGCTTCCTCTTCCACTCCT GCTACAGGTGTCTTCTTGAAGTCCTGGGTCTATCAGCCAGGAGAGGACACAGAGGAGGAG GAAGATGAGGACAGTGATACAGGATCAGCCGAGGATGAAAGAGAAGCTGAGACTTCTGCT TCCACACCCCCTGCAAGTGCTTTCTTGAAGGCCTGGGTGTATCGGCCAGGAGAGGACACG GAGGAGGAGGAAGATGAGGATGTGGATAGTGAGGATAAGGAAGATGATTCAGAAGCAGCC TTGGGAGAAGCTGAGTCAGACCCACATCCCTCCCACCCGGACCAGAGGGCCCACTTCAGG GGCTGGGGATATCGACCTGGAAAAGAGACAGAGGAAGAGGAAGCTGCTGAGGACTGGGGA GAAGCTGAGCCCTGCCCCTTCCGAGTGGCCATCTATGTACCTGGAGAGAAGCCACCGCCT CCCTGGGCTCCTCCTAGGCTGCCCCTCCGACTGCAAAGGCGGCTCAAGCGCCCAGAAACC CCTACTCATGATCCGGACCCTGAGACTCCCCTAAAGGCCAGAAAGGTGCGCTTCTCCGAG AAGGTCACTGTCCATTTCCTGGCTGTCTGGGCAGGGCCGGCCCAGGCCGCCCGCCAGGGC CCCTGGGAGCAGCTTGCTCGGGATCGCAGCCGCTTCGCACGCCGCATCACCCAGGCCCAG GAGGAGCTGAGCCCCTGCCTCACCCCTGCTGCCCGGGCCAGAGCCTGGGCACGCCTCAGG AACCCACCTTTAGCCCCCATCCCTGCCCTCACCCAGACCTTGCCTTCCTCCTCTGTCCCT TCGTCCCCAGTCCAGACCACGCCCTTGAGCCAAGCTGTGGCCACACCTTCCCGCTCGTCT GCTGCTGCAGCGGCTGCCCTGGACCTCAGTGGGAGGCGTGGCTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:14375
Chromosome Location	19
Locus	Not Available
References	Hollander MC, Zhan Q, Bae I, Fornace AJ Jr: Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. 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