Epididymal secretory glutathione peroxidase

NameEpididymal secretory glutathione peroxidase
Synonyms
  • 1.11.1.9
  • EGLP
  • Epididymis-specific glutathione peroxidase-like protein
  • Glutathione peroxidase 5
  • GPx-5
  • GSHPx-5
Gene NameGPX5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001636|Epididymal secretory glutathione peroxidase
MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYV
GKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLK
YVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIR
WNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK
Number of residues221
Molecular Weight25202.14
Theoretical pI8.89
GO Classification
Functions
  • glutathione peroxidase activity
Processes
  • lipid metabolic process
  • cellular response to oxidative stress
Components
  • sperm plasma membrane
  • extracellular space
General FunctionGlutathione peroxidase activity
Specific FunctionProtects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID3288455
UniProtKB IDO75715
UniProtKB Entry NameGPX5_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0016218|Epididymal secretory glutathione peroxidase (GPX5)
ATGACTACACAGTTAAGGGTCGTCCATCTGCTTCCCCTTCTCCTAGCCTGCTTTGTGCAA
ACAAGTCCCAAGCAGGAGAAGATGAAGATGGATTGCCACAAAGACGAGAAAGGCACCATC
TATGACTATGAGGCCATCGCACTTAATAAGAATGAATATGTTTCCTTCAAGCAGTATGTG
GGCAAGCACATCCTCTTCGTCAACGTGGCCACCTACTGTGGTCTGACAGCGCAATATCCT
GAACTAAATGCACTCCAGGAGGAGCTGAAGCCCTATGGTCTAGTTGTGTTGGGCTTTCCC
TGCAACCAATTTGGAAAGCAAGAACCAGGAGATAACAAAGAGATTCTTCCTGGGCTCAAG
TATGTCCGTCCAGGGGGAGGATTTGTACCTAGTTTCCAGCTTTTTGAGAAAGGGGATGTG
AATGGTGAAAAAGAACAGAAAGTCTTCAGTTTCTTGAAGCACTCCTGTCCTCATCCCTCT
GAGATTTTGGGCACATTCAAATCTATATCCTGGGACCCTGTAAAGGTCCATGACATCCGT
TGGAACTTTGAAAAGTTCCTGGTGGGGCCTGATGGAATCCCTGTCATGCGCTGGTCCCAC
CGGGCTACGGTCAGCTCAGTCAAGACAGACATCCTGGCGTACTTGAAGCAATTCAAAACC
AAATAG
GenBank Gene IDAJ005277
GeneCard IDNot Available
GenAtlas IDGPX5
HGNC IDHGNC:4557
Chromosome Location6
Locus6p22.1
References
  1. Hall L, Williams K, Perry AC, Frayne J, Jury JA: The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract. Biochem J. 1998 Jul 1;333 ( Pt 1):5-9. 9639555
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