NameNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Synonyms
  • 1.6.5.3
  • CI-30kD
  • Complex I-30kD
  • NADH-ubiquinone oxidoreductase 30 kDa subunit
Gene NameNDUFS3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000381|NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSA
FGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVP
TRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFAN
HPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWE
AFPVYRQPPESLKLEAGDKKPDAK
Number of residues264
Molecular Weight30241.245
Theoretical pI7.62
GO Classification
Functions
  • electron carrier activity
  • NADH dehydrogenase (ubiquinone) activity
  • NADH dehydrogenase activity
Processes
  • reactive oxygen species metabolic process
  • small molecule metabolic process
  • cellular metabolic process
  • respiratory electron transport chain
  • negative regulation of intrinsic apoptotic signaling pathway
  • substantia nigra development
  • negative regulation of cell growth
  • mitochondrial electron transport, NADH to ubiquinone
Components
  • mitochondrial membrane
  • myelin sheath
  • mitochondrial respiratory chain complex I
  • mitochondrion
  • nucleus
  • mitochondrial matrix
General FunctionNadh dehydrogenase activity
Specific FunctionCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID3337441
UniProtKB IDO75489
UniProtKB Entry NameNDUS3_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0010194|NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (NDUFS3)
ATGGCGGCGGCGGCGGTAGCCAGGCTGTGGTGGCGCGGGATCTTGGGGGCCTCGGCGCTG
ACCAGGGGGACTGGGCGACCCTCCGTTCTGTTGCTGCCGGTGAGGCGGGAGAGCGCCGGG
GCCGACACGCGCCCCACTGTCAGACCACGGAATGATGTGGCCCACAAGCAGCTCTCAGCT
TTTGGAGAGTATGTGGCTGAAATCTTGCCCAAGTATGTCCAACAAGTTCAGGTGTCCTGC
TTCAATGAGTTAGAGGTCTGTATCCATCCTGATGGCGTCATCCCAGTGCTGACTTTCCTC
AGGGATCACACCAATGCACAGTTCAAATCTCTGGTTGACTTGACAGCAGTGGACGTCCCA
ACTCGGCAAAACCGTTTTGAGATTGTCTACAACCTGTTGTCTCTGCGCTTCAACTCACGG
ATCCGTGTGAAGACCTACACAGATGAGCTGACGCCCATTGAGTCTGCTGTCTCTGTGTTC
AAGGCAGCCAACTGGTATGAAAGGGAGATCTGGGACATGTTTGGAGTCTTCTTTGCTAAC
CACCCTGATCTAAGAAGGATCCTGACAGATTATGGCTTCGAGGGACATCCTTTCCGGAAA
GACTTTCCTCTATCTGGCTATGTTGAGTTACGTTATGATGATGAAGTGAAGCGGGTGGTG
GCAGAGCCGGTGGAGTTGGCCCAAGAGTTCCGCAAATTTGACCTGAACAGCCCCTGGGAG
GCTTTCCCAGTCTATCGCCAACCCCCGGAGAGTCTCAAGCTTGAAGCCGGAGACAAGAAG
CCTGATGCCAAGTAG
GenBank Gene IDAF067139
GeneCard IDNot Available
GenAtlas IDNDUFS3
HGNC IDHGNC:7710
Chromosome Location11
Locus11p11.11
References
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