Programmed cell death protein 6

NameProgrammed cell death protein 6
Synonyms
  • ALG2
  • Apoptosis-linked gene 2 protein
  • Probable calcium-binding protein ALG-2
Gene NamePDCD6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009841|Programmed cell death protein 6
MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPF
NPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALS
GFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSY
EQYLSMVFSIV
Number of residues191
Molecular Weight21868.32
Theoretical pINot Available
GO Classification
Functions
  • calcium-dependent protein binding
  • protein dimerization activity
  • calcium-dependent cysteine-type endopeptidase activity
  • binding, bridging
  • identical protein binding
  • protein anchor
  • calcium ion binding
Processes
  • positive regulation of endothelial cell proliferation
  • proteolysis
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • intracellular protein transport
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • negative regulation of TOR signaling
  • cellular response to heat
  • negative regulation of protein kinase B signaling
  • response to calcium ion
  • negative regulation of vascular endothelial growth factor receptor signaling pathway
  • vascular endothelial growth factor receptor-2 signaling pathway
  • angiogenesis
  • positive regulation of endothelial cell migration
  • positive regulation of angiogenesis
  • apoptotic signaling pathway
Components
  • nucleus
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • cytoplasmic vesicle
  • extracellular exosome
  • endoplasmic reticulum exit site
  • nuclear membrane
  • endosome
  • cytoplasm
General FunctionProtein dimerization activity
Specific FunctionCalcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO75340
UniProtKB Entry NamePDCD6_HUMAN
Cellular LocationNucleus membrane
Gene sequence
>lcl|BSEQ0017845|Programmed cell death protein 6 (PDCD6)
ATGGCCGCCTACTCTTACCGCCCCGGCCCTGGGGCCGGCCCTGGGCCTGCTGCAGGCGCG
GCGCTGCCGGACCAGAGCTTCCTGTGGAACGTTTTCCAGAGGGTCGATAAAGACAGGAGT
GGAGTGATATCAGACACCGAGCTTCAGCAAGCTCTCTCCAACGGCACGTGGACTCCCTTT
AATCCAGTGACTGTCAGGTCGATCATATCCATGTTTGACCGTGAGAACAAGGCCGGCGTG
AACTTCAGCGAGTTCACGGGTGTGTGGAAGTACATCACGGACTGGCAGAACGTCTTCCGC
ACGTACGACCGGGACAACTCCGGGATGATCGATAAGAACGAGCTGAAGCAGGCCCTCTCA
GGCTACCGGCTCTCTGACCAGTTCCACGACATCCTCATTCGAAAGTTTGACAGGCAGGGA
CGGGGGCAGATTGCCTTCGACGACTTCATCCAGGGCTGCATCGTCCTGCAGAGGTTGACG
GATATATTCAGACGTTACGACACGGATCAGGACGGCTGGATTCAGGTGTCGTACGAACAG
TACCTGTCCATGGTCTTCAGTATCGTATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:8765
Chromosome Location5
LocusNot Available
References
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