Lysine-specific demethylase PHF2
| Name | Lysine-specific demethylase PHF2 |
|---|---|
| Synonyms |
|
| Gene Name | PHF2 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0037291|Lysine-specific demethylase PHF2 MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKS TLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEE HGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDY YYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLIC VKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVD KCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSL TQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHED ELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATP PQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASP TIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSE AKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFG ALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTK PKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYN PSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKS AGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSD DAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLT PNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSS LADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQ RLGKILKIHRNGKLLL |
| Number of residues | 1096 |
| Molecular Weight | 120773.925 |
| Theoretical pI | Not Available |
| GO Classification | Functions
Processes
Components
|
| General Function | Zinc ion binding |
| Specific Function | Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. |
| Pfam Domain Function | |
| Transmembrane Regions | Not Available |
| GenBank Protein ID | Not Available |
| UniProtKB ID | O75151 |
| UniProtKB Entry Name | PHF2_HUMAN |
| Cellular Location | Nucleus |
| Gene sequence | >lcl|BSEQ0017853|Lysine-specific demethylase PHF2 (PHF2) ATGGCGACGGTGCCCGTGTACTGCGTCTGCCGGCTCCCCTACGACGTTACCCGCTTCATG ATCGAGTGCGACGCCTGCAAGGACTGGTTCCACGGCAGCTGTGTTGGGGTGGAAGAGGAG GAGGCGCCCGACATCGACATATACCACTGCCCAAACTGTGAGAAAACCCATGGGAAGTCC ACCTTAAAGAAGAAGCGGACCTGGCACAAACACGGCCCGGGGCAAGCGCCTGACGTCAAG CCCGTGCAGAATGGCAGCCAGCTCTTCATCAAGGAGCTGCGGAGCCGGACCTTTCCCAGT GCTGAAGACGTGGTGGCCCGTGTGCCAGGAAGTCAGCTCACGCTGGGCTACATGGAGGAG CACGGCTTCACCGAGCCCATCCTCGTCCCTAAGAAAGACGGGCTGGGTCTGGCTGTCCCG GCCCCCACGTTCTATGTCAGTGACGTCGAGAACTACGTGGGGCCGGAACGGAGTGTGGAT GTGACAGATGTCACCAAGCAGAAGGACTGCAAGATGAAGCTGAAGGAGTTTGTGGACTAT TACTACAGCACCAACCGCAAGCGGGTCCTCAACGTCACCAACCTCGAGTTCTCTGACACC CGAATGTCCAGCTTCGTGGAGCCACCTGACATTGTAAAGAAACTGTCATGGGTAGAAAAC TACTGGCCAGATGATGCATTGCTGGCCAAGCCCAAAGTGACCAAGTACTGCCTAATCTGC GTGAAGGACAGTTACACCGACTTCCACATCGACTCTGGGGGCGCCTCTGCCTGGTACCAC GTGCTCAAGGGGGAGAAGACCTTCTATCTCATCAGGCCGGCCTCGGCCAACATCTCCCTG TATGAGCGCTGGCGGTCTGCCTCTAACCACAGCGAGATGTTCTTTGCTGACCAGGTCGAC AAATGCTACAAGTGCATCGTCAAGCAGGGCCAGACCCTCTTCATCCCCTCAGGCTGGATC TACGCCACACTCACCCCTGTGGACTGCCTGGCCTTCGCGGGACATTTCCTCCACAGCCTG AGTGTGGAGATGCAGATGAGAGCATATGAAGTGGAAAGGAGGTTGAAACTGGGCAGCCTG ACTCAGTTTCCCAACTTTGAAACTGCGTGCTGGTACATGGGGAAGCACCTGCTGGAGGCA TTCAAAGGCTCTCACAAATCTGGGAAGCAGCTGCCCCCTCATCTAGTCCAAGGAGCTAAA ATTCTCAATGGTGCTTTCCGATCGTGGACGAAGAAGCAGGCTTTGGCAGAGCATGAGGAC GAGCTCCCGGAGCACTTCAAACCTTCACAGCTAATCAAAGACCTGGCCAAAGAGATCCGG CTCAGTGAGAATGCCTCCAAAGCCGTCCGACCGGAAGTGAATACTGTCGCCTCGTCAGAT GAGGTGTGTGACGGGGACCGGGAGAAGGAGGAGCCCCCGTCTCCCATTGAGGCCACCCCG CCTCAATCCCTCCTGGAGAAAGTGTCCAAAAAAAAGACTCCCAAAACTGTGAAGATGCCC AAGCCATCCAAAATCCCCAAGCCCCCGAAGCCCCCTAAGCCCCCAAGGCCCCCCAAAACG CTGAAGCTCAAAGATGGAGGCAAGAAGAAAGGGAAGAAGTCCCGGGAGTCAGCCTCACCC ACCATCCCCAACCTGGACCTGCTCGAAGCCCACACCAAGGAGGCACTGACCAAGATGGAG CCGCCCAAGAAGGGCAAGGCCACAAAGAGTGTCCTGAGTGTGCCCAACAAAGATGTGGTT CACATGCAGAATGATGTGGAGAGGCTGGAAATTCGAGAGCAAACCAAGAGCAAGTCAGAG GCCAAGTGGAAGTACAAGAACAGCAAACCTGACTCCTTACTGAAGATGGAAGAGGAGCAG AAGCTAGAGAAGTCGCCTCTAGCTGGAAACAAAGACAATAAGTTCTCTTTTTCTTTCTCC AACAAGAAACTCCTCGGCTCCAAGGCTCTCAGGCCCCCGACGAGCCCTGGTGTGTTCGGG GCCTTGCAGAACTTCAAGGAGGACAAGCCCAAGCCCGTGCGGGATGAGTATGAGTACGTG TCGGATGACGGTGAGCTCAAGATCGACGAGTTTCCCATCAGGAGGAAGAAAAACGCCCCG AAAAGGGACTTGTCCTTCTTGTTGGATAAGAAGGCTGTGCTGCCCACGCCTGTCACGAAG CCAAAGCTGGACTCGGCAGCGTACAAGAGTGATGACTCCTCGGACGAGGGTTCGCTGCAC ATCGACACAGACACCAAGCCCGGCCGCAATGCCAGAGTCAAGAAGGAGAGTGGGAGCTCG GCAGCTGGCATCTTGGACCTGCTGCAGGCCAGTGAGGAGGTTGGCGCGCTGGAGTACAAC CCCAGCAGCCAGCCCCCGGCCTCCCCCAGCACACAGGAAGCCATTCAGGGAATGCTGTCC ATGGCCAACCTGCAGGCCTCCGACTCCTGCCTGCAGACCACGTGGGGAGCTGGCCAGGCC AAGGGGAGCTCGCTGGCTGCCCATGGTGCCCGGAAGAATGGGGGTGGCAGTGGCAAGAGT GCAGGCAAACGACTGCTGAAGAGGGCTGCCAAGAACAGTGTCGACCTGGACGACTACGAG GAAGAGCAGGACCACCTGGATGCCTGCTTCAAGGACTCAGACTACGTTTACCCCTCACTG GAGTCAGATGAAGACAACCCCATCTTTAAGTCCCGGTCGAAGAAAAGGAAAGGCTCAGAC GACGCTCCCTACAGCCCAACAGCAAGGGTCGGCCCATCGGTGCCAAGACAGGACAGGCCT GTGCGTGAGGGTACACGGGTGGCTTCCATCGAGACCGGGCTGGCGGCTGCTGCAGCTAAG TTGTCCCAGCAGGAGGAGCAGAAAAGCAAGAAAAAAAAGAGTGCCAAGAGGAAGCTGACT CCTAACACCACCTCCCCTTCCACCTCCACCTCCATCTCTGCCGGCACCACCTCCACCTCC ACCACGCCAGCCTCTACCACCCCGGCCTCCACCACCCCGGCCTCCACCAGCACGGCCAGC AGCCAGGCCTCGCAGGAGGGCAGCTCGCCAGAGCCCCCGCCTGAGTCGCATAGCAGCAGC CTGGCGGACCATGAGTACACAGCCGCTGGCACCTTCACCGGGGCCCAGGCTGGCCGCACC TCCCAGCCCATGGCCCCTGGGGTCTTTCTCACACAGAGGCGGCCCTCCGCATCGTCTCCA AACAACAACACCGCTGCCAAAGGAAAACGTACGAAAAAGGGCATGGCGACCGCCAAGCAG AGGCTTGGGAAAATTTTGAAAATTCATCGGAACGGGAAACTACTCCTTTAA |
| GenBank Gene ID | Not Available |
| GeneCard ID | Not Available |
| GenAtlas ID | Not Available |
| HGNC ID | HGNC:8920 |
| Chromosome Location | 9 |
| Locus | Not Available |
| References |
|