Sodium channel subunit beta-2

NameSodium channel subunit beta-2
SynonymsNot Available
Gene NameSCN2B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012528|Sodium channel subunit beta-2
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNH
KQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPE
DEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVV
KCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK
Number of residues215
Molecular Weight24325.69
Theoretical pI6.35
GO Classification
Functions
  • sodium channel regulator activity
  • voltage-gated sodium channel activity involved in cardiac muscle cell action potential
Processes
  • regulation of sodium ion transmembrane transporter activity
  • response to pyrethroid
  • synaptic transmission
  • sodium ion transmembrane transport
  • nervous system development
  • cardiac muscle cell action potential involved in contraction
  • cardiac muscle contraction
  • membrane depolarization during cardiac muscle cell action potential
  • regulation of atrial cardiac muscle cell membrane depolarization
  • regulation of heart rate by cardiac conduction
Components
  • voltage-gated sodium channel complex
General FunctionVoltage-gated sodium channel activity involved in cardiac muscle cell action potential
Specific FunctionCrucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
Pfam Domain Function
Transmembrane Regions160-180
GenBank Protein ID3309111
UniProtKB IDO60939
UniProtKB Entry NameSCN2B_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0012529|Sodium channel subunit beta-2 (SCN2B)
ATGCACAGAGATGCCTGGCTACCTCGCCCTGCCTTCAGCCTCACGGGGCTCAGTCTCTTT
TTCTCTTTGGTGCCACCAGGACGGAGCATGGAGGTCACAGTACCTGCCACCCTCAACGTC
CTCAATGGCTCTGACGCCCGCCTGCCCTGCACCTTCAACTCCTGCTACACAGTGAACCAC
AAACAGTTCTCCCTGAACTGGACTTACCAGGAGTGCAACAACTGCTCTGAGGAGATGTTC
CTCCAGTTCCGCATGAAGATCATTAACCTGAAGCTGGAGCGGTTTCAAGACCGCGTGGAG
TTCTCAGGGAACCCCAGCAAGTACGATGTGTCGGTGATGCTGAGAAACGTGCAGCCGGAG
GATGAGGGGATTTACAACTGCTACATCATGAACCCCCCTGACCGCCACCGTGGCCATGGC
AAGATCCATCTGCAGGTCCTCATGGAAGAGCCCCCTGAGCGGGACTCCACGGTGGCCGTG
ATTGTGGGTGCCTCCGTCGGGGGCTTCCTGGCTGTGGTCATCTTGGTGCTGATGGTGGTC
AAGTGTGTGAGGAGAAAAAAAGAGCAGAAGCTGAGCACAGATGACCTGAAGACCGAGGAG
GAGGGCAAGACGGACGGTGAAGGCAACCCGGATGATGGCGCCAAGTAG
GenBank Gene IDAF007783
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:10589
Chromosome Location11
Locus11q23
References
  1. Eubanks J, Srinivasan J, Dinulos MB, Disteche CM, Catterall WA: Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel. Neuroreport. 1997 Aug 18;8(12):2775-9. 9295116
  2. Bolino A, Seri M, Caroli F, Eubanks J, Srinivasan J, Mandich P, Schenone A, Quattrone A, Romeo G, Catterall WA, Devoto M: Exclusion of the SCN2B gene as candidate for CMT4B. Eur J Hum Genet. 1998 Nov-Dec;6(6):629-34. 9887383
  3. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. 12975309
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  5. Chen C, Calhoun JD, Zhang Y, Lopez-Santiago L, Zhou N, Davis TH, Salzer JL, Isom LL: Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 subunits. J Biol Chem. 2012 Nov 9;287(46):39061-9. doi: 10.1074/jbc.M112.397646. Epub 2012 Sep 19. 22992729
  6. Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM: Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol. 2009 Jun;2(3):268-75. doi: 10.1161/CIRCEP.108.779181. Epub 2009 Mar 6. 19808477
  7. Riuro H, Beltran-Alvarez P, Tarradas A, Selga E, Campuzano O, Verges M, Pagans S, Iglesias A, Brugada J, Brugada P, Vazquez FM, Perez GJ, Scornik FS, Brugada R: A missense mutation in the sodium channel beta2 subunit reveals SCN2B as a new candidate gene for Brugada syndrome. Hum Mutat. 2013 Jul;34(7):961-6. doi: 10.1002/humu.22328. Epub 2013 Apr 29. 23559163