NameInward rectifier potassium channel 13
Synonyms
  • Inward rectifier K(+) channel Kir7.1
  • Potassium channel, inwardly rectifying subfamily J member 13
Gene NameKCNJ13
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008952|Inward rectifier potassium channel 13
MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVF
SASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTI
GYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAH
MDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFP
LTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFA
SLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE
Number of residues360
Molecular Weight40529.195
Theoretical pINot Available
GO Classification
Functions
  • inward rectifier potassium channel activity
Processes
  • potassium ion import
  • regulation of ion transmembrane transport
  • potassium ion transport
Components
  • integral component of plasma membrane
General FunctionInward rectifier potassium channel activity
Specific FunctionInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
Pfam Domain Function
Transmembrane Regions54-78 134-155
GenBank Protein IDNot Available
UniProtKB IDO60928
UniProtKB Entry NameKCJ13_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0017645|Inward rectifier potassium channel 13 (KCNJ13)
ATGGACAGCAGTAATTGCAAAGTTATTGCTCCTCTCCTAAGTCAAAGATACCGGAGGATG
GTCACCAAGGATGGCCACAGCACACTTCAAATGGATGGCGCTCAAAGAGGTCTTGCATAT
CTTCGAGATGCTTGGGGAATCCTAATGGACATGCGCTGGCGTTGGATGATGTTGGTCTTT
TCTGCTTCTTTTGTTGTCCACTGGCTTGTCTTTGCAGTGCTCTGGTGCTTTTGTGGCGAA
GATTGCCCGGCCAAAAAATCGAGCTTTTTCAATTCGCTTTACTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6259
Chromosome Location2
LocusNot Available
References
  1. Partiseti M, Collura V, Agnel M, Culouscou JM, Graham D: Cloning and characterization of a novel human inwardly rectifying potassium channel predominantly expressed in small intestine. FEBS Lett. 1998 Aug 28;434(1-2):171-6. 9738472
  2. Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE: A novel inward rectifier K+ channel with unique pore properties. Neuron. 1998 May;20(5):995-1005. 9620703
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