NameMonocarboxylate transporter 2
Synonyms
  • MCT 2
  • MCT2
  • Solute carrier family 16 member 7
Gene NameSLC16A7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010306|Monocarboxylate transporter 2
MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAW
ISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFIT
GLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLI
LGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFS
LFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSV
GLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFE
TLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW
LLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
Number of residues478
Molecular Weight52199.745
Theoretical pI9.68
GO Classification
Functions
  • symporter activity
  • lactate transmembrane transporter activity
  • pyruvate secondary active transmembrane transporter activity
  • pyruvate transmembrane transporter activity
Processes
  • lactate transmembrane transport
  • pyruvate transmembrane transport
  • transmembrane transport
  • plasma membrane lactate transport
Components
  • cytoplasm
  • plasma membrane
  • integral component of plasma membrane
General FunctionSymporter activity
Specific FunctionProton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
Pfam Domain Function
Transmembrane Regions16-36 60-80 90-110 116-136 149-169 174-194 247-267 283-303 313-333 339-359 374-394 407-427
GenBank Protein ID3047402
UniProtKB IDO60669
UniProtKB Entry NameMOT2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010307|Monocarboxylate transporter 2 (SLC16A7)
ATGCCACCAATGCCAAGTGCCCCACCTGTGCATCCACCTCCAGATGGAGGATGGGGTTGG
ATTGTGGTTGGAGCAGCTTTTATCTCCATTGGATTTTCCTATGCATTCCCCAAAGCTGTC
ACCGTATTCTTCAAAGAAATTCAGCAAATATTCCACACTACCTACAGTGAAATAGCATGG
ATTTCATCCATTATGCTGGCTGTTATGTACGCAGGAGGTCCTGTAAGTAGTGTTTTGGTG
AATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATG
GTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACA
GGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTAT
AGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCA
TTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATT
TTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCC
AATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCA
AAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCC
CTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGT
TTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTAC
TCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTA
GGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCA
ATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTG
GTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAA
ACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATT
GTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACT
GGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGG
CTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAAT
GCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTT
AACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAA
GenBank Gene IDAF058056
GeneCard IDNot Available
GenAtlas IDSLC16A7
HGNC IDHGNC:10928
Chromosome Location12
Locus12q13
References
  1. Lin RY, Vera JC, Chaganti RS, Golde DW: Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. 9786900
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