NameFatty acid desaturase 1
Synonyms
  • 1.14.19.-
  • D5D
  • Delta-5 desaturase
  • Delta(5) desaturase
  • Delta(5) fatty acid desaturase
  • FADSD5
Gene NameFADS1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001770|Fatty acid desaturase 1
MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
Number of residues444
Molecular Weight51963.945
Theoretical pI9.15
GO Classification
Functions
  • C-5 sterol desaturase activity
  • oxidoreductase activity
Processes
  • cellular response to starvation
  • icosanoid biosynthetic process
  • linoleic acid metabolic process
  • phospholipid biosynthetic process
  • unsaturated fatty acid biosynthetic process
  • cell-cell signaling
  • regulation of cell differentiation
  • small molecule metabolic process
  • regulation of transcription, DNA-templated
  • cellular lipid metabolic process
  • alpha-linolenic acid metabolic process
  • unsaturated fatty acid metabolic process
Components
  • mitochondrion
  • membrane
  • endoplasmic reticulum membrane
  • integral component of membrane
  • intracellular membrane-bounded organelle
General FunctionOxidoreductase activity
Specific FunctionIsoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.
Pfam Domain Function
Transmembrane Regions122-142 146-170 268-288 306-326
GenBank Protein ID3169158
UniProtKB IDO60427
UniProtKB Entry NameFADS1_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0010626|Fatty acid desaturase 1 (FADS1)
ATGGGAACGCGCGCTGCGAGGCCCGCCGGTCTGCCCTGCGGTGCTGAAAACCCGGCGCGC
AGGCGGCTGGCTCTGGGCGCGCGCCAGCAAATCCACTCCTGGAGCCCGCGGACCCCGAGC
ACGCGCCTGACAGCCCCTGCTGGCCCGGCGCGCGGCGTCGCCAGGCCAGCTATGGCCCCC
GACCCGGTGGCCGCCGAGACCGCGGCTCAGGGACCTACCCCGCGCTACTTCACCTGGGAC
GAGGTGGCCCAGCGCTCAGGGTGCGAGGAGCGGTGGCTAGTGATCGACCGTAAGGTGTAC
AACATCAGCGAGTTCACCCGCCGGCATCCAGGGGGCTCCCGGGTCATCAGCCACTACGCC
GGGCAGGATGCCACGGATCCCTTTGTGGCCTTCCACATCAACAAGGGCCTTGTGAAGAAG
TATATGAACTCTCTCCTGATTGGAGAACTGTCTCCAGAGCAGCCCAGCTTTGAGCCCACC
AAGAATAAAGAGCTGACAGATGAGTTCCGGGAGCTGCGGGCCACAGTGGAGCGGATGGGG
CTCATGAAGGCCAACCATGTCTTCTTCCTGCTGTACCTGCTGCACATCTTGCTGCTGGAT
GGTGCAGCCTGGCTCACCCTTTGGGTCTTTGGGACGTCCTTTTTGCCCTTCCTCCTCTGT
GCGGTGCTGCTCAGTGCAGTTCAGGCCCAGGCTGGCTGGCTGCAGCATGACTTTGGGCAC
CTGTCGGTCTTCAGCACCTCAAAGTGGAACCATCTGCTACATCATTTTGTGATTGGCCAC
CTGAAGGGGGCCCCCGCCAGTTGGTGGAACCACATGCACTTCCAGCACCATGCCAAGCCC
AACTGCTTCCGCAAAGACCCAGACATCAACATGCATCCCTTCTTCTTTGCCTTGGGGAAG
ATCCTCTCTGTGGAGCTTGGGAAACAGAAGAAAAAATATATGCCGTACAACCACCAGCAC
AAATACTTCTTCCTAATTGGGCCCCCAGCCTTGCTGCCTCTCTACTTCCAGTGGTATATT
TTCTATTTTGTTATCCAGCGAAAGAAGTGGGTGGACTTGGCCTGGATGATTACCTTCTAC
GTCCGCTTCTTCCTCACTTATGTGCCACTATTGGGGCTGAAAGCCTTCCTGGGCCTTTTC
TTCATAGTCAGGTTCCTGGAAAGCAACTGGTTTGTGTGGGTGACACAGATGAACCATATT
CCCATGCACATTGATCATGACCGGAACATGGACTGGGTTTCCACCCAGCTCCAGGCCACA
TGCAATGTCCACAAGTCTGCCTTCAATGACTGGTTCAGTGGACACCTCAACTTCCAGATT
GAGCACCATCTTTTTCCCACGATGCCTCGACACAATTACCACAAAGTGGCTCCCCTGGTG
CAGTCCTTGTGTGCCAAGCATGGCATAGAGTACCAGTCCAAGCCCCTGCTGTCAGCCTTC
GCCGACATCATCCACTCACTAAAGGAGTCAGGGCAGCTCTGGCTAGATGCCTATCTTCAC
CAATAA
GenBank Gene IDAC004770
GeneCard IDNot Available
GenAtlas IDDKFZp762M2311
HGNC IDHGNC:3574
Chromosome Location11
LocusNot Available
References
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