Protein phosphatase 1 regulatory subunit 12B

NameProtein phosphatase 1 regulatory subunit 12B
Synonyms
  • Myosin phosphatase target subunit 2
  • Myosin phosphatase-targeting subunit 2
  • MYPT2
Gene NamePPP1R12B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009116|Protein phosphatase 1 regulatory subunit 12B
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA
VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ
DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ
GVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG
YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL
LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS
SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS
SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL
LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI
PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV
LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT
FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR
LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN
EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG
GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL
QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELK
SDNQRLKDENGALIRVISKLSK
Number of residues982
Molecular Weight110402.735
Theoretical pINot Available
GO Classification
Functions
  • enzyme activator activity
  • phosphatase regulator activity
Processes
  • signal transduction
  • small GTPase mediated signal transduction
  • G2/M transition of mitotic cell cycle
  • mitotic cell cycle
  • positive regulation of catalytic activity
  • regulation of muscle contraction
Components
  • plasma membrane
  • actin cytoskeleton
  • cytosol
  • nucleoplasm
  • Z disc
  • A band
General FunctionPhosphatase regulator activity
Specific FunctionRegulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO60237
UniProtKB Entry NameMYPT2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017695|Protein phosphatase 1 regulatory subunit 12B (PPP1R12B)
ATGGCGGAACTGGAGCACCTAGGAGGGAAGCGGGCAGAGTCGGCGCGAATGCGGCGGGCA
GAGCAGCTTCGGCGCTGGCGGGGCTCGCTGACAGAGCAGGAGCCTGCGGAGCGACGAGGC
GCGGGGCGGCAGCCGCTGACCAGGCGCGGGAGCCCCAGGGTCCGCTTCGAGGACGGTGCT
GTCTTTCTGGCCGCCTGCTCTAGCGGGGACACCGACGAGGTGAGAAAGCTTCTGGCAAGA
GGTGCTGATATCAACACGGTCAACGTGGACGGCTTGACAGCCCTGCACCAGGCATGTATT
GATGAAAATTTGGACATGGTGAAGTTTCTGGTGGAGAACAGAGCCAATGTAAACCAGCAA
GACAACGAGGGCTGGACACCCCTTCATGCAGCAGCTTCCTGTGGCTATCTCAACATAGCA
GAGTATTTCATTAATCACGGAGCCAGTGTAGGTATTGTCAATAGTGAAGGTGAAGTTCCC
TCTGACCTTGCAGAAGAGCCAGCCATGAAGGATCTTCTTCTGGAGCAAGTAAAGAAGCAA
GGAGTTGATCTAGAGCAGTCAAGAAAAGAAGAAGAGCAGCAGATGTTGCAGGATGCCCGC
CAGTGGCTCAACAGTGGGAAAATAGAGGATGTGAGGCAGGCTCGCTCAGGGGCTACAGCC
CTTCATGTGGCTGCTGCCAAGGGCTACTCTGAAGTCCTCAGACTTTTAATTCAGGCTGGC
TATGAACTCAATGTTCAGGATTATGATGGCTGGACTCCCCTCCATGCTGCTGCACACTGG
GGAGTGAAGGAGGCTTGCTCCATCCTGGCAGAAGCACTTTGTGACATGGATATTCGAAAT
AAACTGGGCCAGACACCATTTGATGTGGCTGATGAGGGTCTCGTGGAGCATTTGGAGTTG
CTCCAGAAGAAGCAGAATGTGCTTCGAAGTGAAAAGGAGACACGGAATAAACTCATTGAG
TCAGATCTGAACAGCAAGATTCAGAGTGGGTTCTTTAAGAACAAAGAGAAGATGCTCTAT
GAGGAGGAGACACCTAAGTCCCAAGAAATGGAGGAAGAAAATAAAGAATCTAGTAGCTCC
AGCTCAGAGGAGGAGGAAGGTGAAGATGAAGCTTCTGAGTCAGAAACTGAGAAGGAGGCA
GATAAAAAGCCAGAAGCCTTTGTCAATCATTCCAACTCTGAAAGCAAGAGTAGTATCACA
GAGCAGATACCAGCACCAGCTCAAAATACCTTCTCTGCCTCTTCTGCTAGGAGGTTCTCT
TCTGGCCTTTTTAACAAGCCAGAAGAGCCCAAAGATGAATCTCCTTCTTCATGGAGATTG
GGACTGAGAAAAACTGGCAGCCACAACATGCTGAGTGAGGTGGCCAATTCCAGGGAACCT
ATAAGGGACCGAGGCTCTTCCATCTATCGCTCCTCTTCAAGCCCTCGGATTTCTGCTCTA
CTGGACAACAAAGATAAGGTGCAGTTTGGGAGGGTATGGGGGAATTCCAAGGCAGTTTTT
TTTTTCCATGAAAATTCAATCTTAGGAACAAATGAAAATATTTTCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:7619
Chromosome Location1
LocusNot Available
References
  1. Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M: A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. Genomics. 1998 Apr 1;49(1):59-68. 9570949
  2. Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A: Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. J Biol Chem. 2001 Mar 2;276(9):6073-82. Epub 2000 Nov 6. 11067852
  3. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. 16710414
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  5. Bannert N, Vollhardt K, Asomuddinov B, Haag M, Konig H, Norley S, Kurth R: PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits. J Biol Chem. 2003 Oct 24;278(43):42190-9. Epub 2003 Aug 14. 12923170