Histone-lysine N-methyltransferase SUV39H1

NameHistone-lysine N-methyltransferase SUV39H1
Synonyms
  • 2.1.1.43
  • H3-K9-HMTase 1
  • Histone H3-K9 methyltransferase 1
  • KMT1A
  • Lysine N-methyltransferase 1A
  • Position-effect variegation 3-9 homolog
  • Su(var)3-9 homolog 1
  • Suppressor of variegation 3-9 homolog 1
  • SUV39H
Gene NameSUV39H1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009315|Histone-lysine N-methyltransferase SUV39H1
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYY
LVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQ
KAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVG
CECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKG
IRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFD
LDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEE
LTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
Number of residues412
Molecular Weight47907.065
Theoretical pINot Available
GO Classification
Functions
  • zinc ion binding
  • chromatin binding
  • histone methyltransferase activity (H3-K9 specific)
  • S-adenosylmethionine-dependent methyltransferase activity
  • RNA polymerase II regulatory region sequence-specific DNA binding
  • protein N-terminus binding
  • transcription regulatory region sequence-specific DNA binding
  • histone-lysine N-methyltransferase activity
  • histone methyltransferase activity
Processes
  • histone H3-K9 dimethylation
  • cellular response to hypoxia
  • transcription, DNA-templated
  • negative regulation of transcription, DNA-templated
  • viral process
  • histone H3-K9 trimethylation
  • cell cycle
  • negative regulation of circadian rhythm
  • negative regulation of gene expression, epigenetic
  • rhythmic process
  • regulation of gene expression, epigenetic
  • chromatin organization
  • rRNA processing
  • gene expression
  • cell differentiation
  • cellular response to DNA damage stimulus
  • response to amphetamine
  • response to nutrient levels
  • chromatin silencing at rDNA
  • negative regulation of transcription from RNA polymerase II promoter
Components
  • nuclear lamina
  • heterochromatin
  • nucleus
  • rDNA heterochromatin
  • chromatin silencing complex
  • chromosome, centromeric region
  • nucleoplasm
  • condensed nuclear chromosome
General FunctionZinc ion binding
Specific FunctionHistone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO43463
UniProtKB Entry NameSUV91_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013735|Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)
ATGGTGGGGATGAGTCGCCTGAGAAATGACAGACTGGCTGACCCACTGACAGGCTGCAGC
GTGTGTTGCAAGTCTTCTTGGAATCAGCTGCAGGACCTGTGCCGCCTGGCCAAGCTCTCC
TGCCCTGCCCTCGGTATCTCTAAGAGGAACCTCTATGACTTTGAAGTCGAGTACCTGTGC
GATTACAAGAAGATCCGCGAACAGGAATATTACCTGGTGAAATGGCGTGGATATCCAGAC
TCAGAGAGCACCTGGGAGCCACGGCAGAATCTCAAGTGTGTGCGTATCCTCAAGCAGTTC
CACAAGGACTTAGAAAGGGAGCTGCTCCGGCGGCACCACCGGTCAAAGACCCCCCGGCAC
CTGGACCCAAGCTTGGCCAACTACCTGGTGCAGAAGGCCAAGCAGAGGCGGGCGCTCCGT
CGCTGGGAGCAGGAGCTCAATGCCAAGCGCAGCCATCTGGGACGCATCACTGTAGAGAAT
GAGGTGGACCTGGACGGCCCTCCGCGGGCCTTCGTGTACATCAATGAGTACCGTGTTGGT
GAGGGCATCACCCTCAACCAGGTGGCTGTGGGCTGCGAGTGCCAGGACTGTCTGTGGGCA
CCCACTGGAGGCTGCTGCCCGGGGGCGTCACTGCACAAGTTTGCCTACAATGACCAGGGC
CAGGTGCGGCTTCGAGCCGGGCTGCCCATCTACGAGTGCAACTCCCGCTGCCGCTGCGGC
TATGACTGCCCAAATCGTGTGGTACAGAAGGGTATCCGATATGACCTCTGCATCTTCCGC
ACGGATGATGGGCGTGGCTGGGGCGTCCGCACCCTGGAGAAGATTCGCAAGAACAGCTTC
GTCATGGAGTACGTGGGAGAGATCATTACCTCAGAGGAGGCAGAGCGGCGGGGCCAGATC
TACGACCGTCAGGGCGCCACCTACCTCTTTGACCTGGACTACGTGGAGGACGTGTACACC
GTGGATGCCGCCTACTATGGCAACATCTCCCACTTTGTCAACCACAGTTGTGACCCCAAC
CTGCAGGTGTACAACGTCTTCATAGACAACCTTGACGAGCGGCTGCCCCGCATCGCTTTC
TTTGCCACAAGAACCATCCGGGCAGGCGAGGAGCTCACCTTTGATTACAACATGCAAGTG
GACCCCGTGGACATGGAGAGCACCCGCATGGACTCCAACTTTGGCCTGGCTGGGCTCCCT
GGCTCCCCTAAGAAGCGGGTCCGTATTGAATGCAAGTGTGGGACTGAGTCCTGCCGCAAA
TACCTCTTCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11479
Chromosome LocationX
LocusNot Available
References
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