Receptor-interacting serine/threonine-protein kinase 2

NameReceptor-interacting serine/threonine-protein kinase 2
Synonyms
  • 2.7.11.1
  • CARD-containing IL-1 beta ICE-kinase
  • CARD-containing interleukin-1 beta-converting enzyme-associated kinase
  • CARDIAK
  • Receptor-interacting protein 2
  • RICK
  • RIP-2
  • RIP-like-interacting CLARP kinase
  • RIP2
  • Tyrosine-protein kinase RIPK2
Gene NameRIPK2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009618|Receptor-interacting serine/threonine-protein kinase 2
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Number of residues540
Molecular Weight61194.345
Theoretical pINot Available
GO Classification
Functions
  • receptor binding
  • non-membrane spanning protein tyrosine kinase activity
  • protein homodimerization activity
  • CARD domain binding
  • LIM domain binding
  • signal transducer activity
  • ATP binding
  • protein serine/threonine kinase activity
Processes
  • toll-like receptor TLR1
  • cellular response to lipoteichoic acid
  • positive regulation of interleukin-12 production
  • positive regulation of tumor necrosis factor production
  • cellular response to peptidoglycan
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • lipopolysaccharide-mediated signaling pathway
  • inflammatory response
  • positive regulation of interferon-beta production
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of ERK1 and ERK2 cascade
  • activation of MAPK activity
  • positive regulation of cytokine-mediated signaling pathway
  • defense response to Gram-positive bacterium
  • JNK cascade
  • cellular response to muramyl dipeptide
  • MyD88-dependent toll-like receptor signaling pathway
  • positive regulation of chemokine production
  • nucleotide-binding oligomerization domain containing 2 signaling pathway
  • MyD88-independent toll-like receptor signaling pathway
  • positive regulation of alpha-beta T cell proliferation
  • positive regulation of interferon-alpha production
  • positive regulation of peptidyl-threonine phosphorylation
  • positive regulation of interferon-gamma production
  • innate immune response
  • response to exogenous dsRNA
  • T cell receptor signaling pathway
  • positive regulation of apoptotic process
  • stress-activated MAPK cascade
  • I-kappaB kinase/NF-kappaB signaling
  • positive regulation of peptidyl-tyrosine phosphorylation
  • nucleotide-binding oligomerization domain containing 1 signaling pathway
  • toll-like receptor 10 signaling pathway
  • positive regulation of protein ubiquitination
  • apoptotic process
  • positive regulation of immature T cell proliferation
  • toll-like receptor 2 signaling pathway
  • positive regulation of JNK cascade
  • negative regulation of apoptotic process
  • response to interleukin-12
  • toll-like receptor 3 signaling pathway
  • toll-like receptor TLR6
  • adaptive immune response
  • neurotrophin TRK receptor signaling pathway
  • response to interleukin-18
  • toll-like receptor 4 signaling pathway
  • signal transduction
  • TRIF-dependent toll-like receptor signaling pathway
  • positive regulation of interleukin-2 production
  • positive regulation of peptidyl-serine phosphorylation
  • T cell proliferation
  • toll-like receptor 5 signaling pathway
  • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
  • positive regulation of T-helper 1 cell differentiation
  • positive regulation of transcription from RNA polymerase II promoter
  • toll-like receptor 9 signaling pathway
  • nucleotide-binding oligomerization domain containing signaling pathway
  • response to interleukin-1
  • positive regulation of interleukin-6 production
  • toll-like receptor signaling pathway
Components
  • cytoskeleton
  • vesicle
  • cytosol
  • cytoplasm
  • protein complex
General FunctionSignal transducer activity
Specific FunctionSerine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO43353
UniProtKB Entry NameRIPK2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017792|Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
ATGAACGGGGAGGCCATCTGCAGCGCCCTGCCCACCATTCCCTACCACAAACTCGCCGAC
CTGCGCTACCTGAGCCGCGGCGCCTCTGGCACTGTGTCGTCCGCCCGCCACGCAGACTGG
CGCGTCCAGGTGGCCGTGAAGCACCTGCACATCCACACTCCGCTGCTCGACAGTGAAAGA
AAGGATGTCTTAAGAGAAGCTGAAATTTTACACAAAGCTAGATTTAGTTACATTCTTCCA
ATTTTGGGAATTTGCAATGAGCCTGAATTTTTGGGAATAGTTACTGAATACATGCCAAAT
GGATCATTAAATGAACTCCTACATAGGAAAACTGAATATCCTGATGTTGCTTGGCCATTG
AGATTTCGCATCCTGCATGAAATTGCCCTTGGTGTAAATTACCTGCACAATATGACTCCT
CCTTTACTTCATCATGACTTGAAGACTCAGAATATCTTATTGGACAATGAATTTCATGTT
AAGATTGCAGATTTTGGTTTATCAAAGTGGCGCATGATGTCCCTCTCACAGTCACGAAGT
AGCAAATCTGCACCAGAAGGAGGGACAATTATCTATATGCCACCTGAAAACTATGAACCT
GGACAAAAATCAAGGGCCAGTATCAAGCACGATATATATAGCTATGCAGTTATCACATGG
GAAGTGTTATCCAGAAAACAGCCTTTTGAAGATGTCACCAATCCTTTGCAGATAATGTAT
AGTGTGTCACAAGGACATCGACCTGTTATTAATGAAGAAAGTTTGCCATATGATATACCT
CACCGAGCACGTATGATCTCTCTAATAGAAAGTGGATGGGCACAAAATCCAGATGAAAGA
CCATCTTTCTTAAAATGTTTAATAGAACTTGAACCAGTTTTGAGAACATTTGAAGAGATA
ACTTTTCTTGAAGCTGTTATTCAGCTAAAGAAAACAAAGTTACAGAGTGTTTCAAGTGCC
ATTCACCTATGTGACAAGAAGAAAATGGAATTATCTCTGAACATACCTGTAAATCATGGT
CCACAAGAGGAATCATGTGGATCCTCTCAGCTCCATGAAAATAGTGGTTCTCCTGAAACT
TCAAGGTCCCTGCCAGCTCCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGT
TATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGA
TCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAAT
CCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATC
CAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTA
GATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAG
CCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAA
TTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTAC
CCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATG
TAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:10020
Chromosome Location8
LocusNot Available
References
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