Receptor-interacting serine/threonine-protein kinase 2

NameReceptor-interacting serine/threonine-protein kinase 2
Synonyms
  • 2.7.11.1
  • CARD-containing IL-1 beta ICE-kinase
  • CARD-containing interleukin-1 beta-converting enzyme-associated kinase
  • CARDIAK
  • Receptor-interacting protein 2
  • RICK
  • RIP-2
  • RIP-like-interacting CLARP kinase
  • RIP2
  • Tyrosine-protein kinase RIPK2
Gene NameRIPK2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009618|Receptor-interacting serine/threonine-protein kinase 2
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Number of residues540
Molecular Weight61194.345
Theoretical pINot Available
GO Classification
Functions
  • LIM domain binding
  • signal transducer activity
  • ATP binding
  • protein serine/threonine kinase activity
  • receptor binding
  • non-membrane spanning protein tyrosine kinase activity
  • protein homodimerization activity
  • CARD domain binding
Processes
  • I-kappaB kinase/NF-kappaB signaling
  • positive regulation of peptidyl-tyrosine phosphorylation
  • toll-like receptor 10 signaling pathway
  • positive regulation of protein ubiquitination
  • nucleotide-binding oligomerization domain containing 1 signaling pathway
  • apoptotic process
  • toll-like receptor 2 signaling pathway
  • positive regulation of JNK cascade
  • positive regulation of immature T cell proliferation
  • negative regulation of apoptotic process
  • toll-like receptor 3 signaling pathway
  • adaptive immune response
  • response to interleukin-12
  • neurotrophin TRK receptor signaling pathway
  • toll-like receptor 4 signaling pathway
  • signal transduction
  • positive regulation of interleukin-2 production
  • response to interleukin-18
  • positive regulation of peptidyl-serine phosphorylation
  • toll-like receptor 5 signaling pathway
  • toll-like receptor TLR6
  • positive regulation of T-helper 1 cell differentiation
  • T cell proliferation
  • positive regulation of transcription from RNA polymerase II promoter
  • toll-like receptor 9 signaling pathway
  • TRIF-dependent toll-like receptor signaling pathway
  • response to interleukin-1
  • positive regulation of interleukin-6 production
  • toll-like receptor signaling pathway
  • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
  • toll-like receptor TLR1
  • nucleotide-binding oligomerization domain containing signaling pathway
  • positive regulation of interleukin-12 production
  • positive regulation of tumor necrosis factor production
  • cellular response to lipoteichoic acid
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • lipopolysaccharide-mediated signaling pathway
  • cellular response to peptidoglycan
  • inflammatory response
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of interferon-beta production
  • defense response to Gram-positive bacterium
  • activation of MAPK activity
  • JNK cascade
  • positive regulation of cytokine-mediated signaling pathway
  • MyD88-dependent toll-like receptor signaling pathway
  • positive regulation of chemokine production
  • cellular response to muramyl dipeptide
  • MyD88-independent toll-like receptor signaling pathway
  • positive regulation of alpha-beta T cell proliferation
  • nucleotide-binding oligomerization domain containing 2 signaling pathway
  • positive regulation of peptidyl-threonine phosphorylation
  • positive regulation of interferon-gamma production
  • positive regulation of interferon-alpha production
  • innate immune response
  • response to exogenous dsRNA
  • T cell receptor signaling pathway
  • positive regulation of apoptotic process
  • stress-activated MAPK cascade
Components
  • cytoplasm
  • protein complex
  • cytoskeleton
  • vesicle
  • cytosol
General FunctionSignal transducer activity
Specific FunctionSerine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO43353
UniProtKB Entry NameRIPK2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017792|Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
ATGAACGGGGAGGCCATCTGCAGCGCCCTGCCCACCATTCCCTACCACAAACTCGCCGAC
CTGCGCTACCTGAGCCGCGGCGCCTCTGGCACTGTGTCGTCCGCCCGCCACGCAGACTGG
CGCGTCCAGGTGGCCGTGAAGCACCTGCACATCCACACTCCGCTGCTCGACAGTGAAAGA
AAGGATGTCTTAAGAGAAGCTGAAATTTTACACAAAGCTAGATTTAGTTACATTCTTCCA
ATTTTGGGAATTTGCAATGAGCCTGAATTTTTGGGAATAGTTACTGAATACATGCCAAAT
GGATCATTAAATGAACTCCTACATAGGAAAACTGAATATCCTGATGTTGCTTGGCCATTG
AGATTTCGCATCCTGCATGAAATTGCCCTTGGTGTAAATTACCTGCACAATATGACTCCT
CCTTTACTTCATCATGACTTGAAGACTCAGAATATCTTATTGGACAATGAATTTCATGTT
AAGATTGCAGATTTTGGTTTATCAAAGTGGCGCATGATGTCCCTCTCACAGTCACGAAGT
AGCAAATCTGCACCAGAAGGAGGGACAATTATCTATATGCCACCTGAAAACTATGAACCT
GGACAAAAATCAAGGGCCAGTATCAAGCACGATATATATAGCTATGCAGTTATCACATGG
GAAGTGTTATCCAGAAAACAGCCTTTTGAAGATGTCACCAATCCTTTGCAGATAATGTAT
AGTGTGTCACAAGGACATCGACCTGTTATTAATGAAGAAAGTTTGCCATATGATATACCT
CACCGAGCACGTATGATCTCTCTAATAGAAAGTGGATGGGCACAAAATCCAGATGAAAGA
CCATCTTTCTTAAAATGTTTAATAGAACTTGAACCAGTTTTGAGAACATTTGAAGAGATA
ACTTTTCTTGAAGCTGTTATTCAGCTAAAGAAAACAAAGTTACAGAGTGTTTCAAGTGCC
ATTCACCTATGTGACAAGAAGAAAATGGAATTATCTCTGAACATACCTGTAAATCATGGT
CCACAAGAGGAATCATGTGGATCCTCTCAGCTCCATGAAAATAGTGGTTCTCCTGAAACT
TCAAGGTCCCTGCCAGCTCCTCAAGACAATGATTTTTTATCTAGAAAAGCTCAAGACTGT
TATTTTATGAAGCTGCATCACTGTCCTGGAAATCACAGTTGGGATAGCACCATTTCTGGA
TCTCAAAGGGCTGCATTCTGTGATCACAAGACCACTCCATGCTCTTCAGCAATAATAAAT
CCACTCTCAACTGCAGGAAACTCAGAACGTCTGCAGCCTGGTATAGCCCAGCAGTGGATC
CAGAGCAAAAGGGAAGACATTGTGAACCAAATGACAGAAGCCTGCCTTAACCAGTCGCTA
GATGCCCTTCTGTCCAGGGACTTGATCATGAAAGAGGACTATGAACTTGTTAGTACCAAG
CCTACAAGGACCTCAAAAGTCAGACAATTACTAGACACTACTGACATCCAAGGAGAAGAA
TTTGCCAAAGTTATAGTACAAAAATTGAAAGATAACAAACAAATGGGTCTTCAGCCTTAC
CCGGAAATACTTGTGGTTTCTAGATCACCATCTTTAAATTTACTTCAAAATAAAAGCATG
TAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:10020
Chromosome Location8
LocusNot Available
References
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