Histone deacetylase 3

NameHistone deacetylase 3
Synonyms
  • 3.5.1.98
  • HD3
  • RPD3-2
  • SMAP45
Gene NameHDAC3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004649|Histone deacetylase 3
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
Number of residues428
Molecular Weight48847.385
Theoretical pI4.79
GO Classification
Functions
  • transcription corepressor activity
  • chromatin binding
  • transcription factor binding
  • histone deacetylase activity
  • chromatin DNA binding
  • enzyme binding
  • histone deacetylase binding
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
  • NF-kappaB binding
  • protein deacetylase activity
  • cyclin binding
Processes
  • circadian rhythm
  • negative regulation of JNK cascade
  • positive regulation of TOR signaling
  • negative regulation of transcription from RNA polymerase II promoter
  • cellular lipid metabolic process
  • chromatin organization
  • regulation of multicellular organism growth
  • regulation of mitotic cell cycle
  • transcription, DNA-templated
  • Notch signaling pathway
  • negative regulation of sequence-specific DNA binding transcription factor activity
  • small molecule metabolic process
  • negative regulation of transcription, DNA-templated
  • protein deacetylation
  • negative regulation of nucleic acid-templated transcription
  • negative regulation of cell cycle
  • positive regulation of protein phosphorylation
  • positive regulation of transcription factor import into nucleus
  • circadian regulation of gene expression
  • spindle assembly
  • cellular response to fluid shear stress
  • negative regulation of apoptotic process
  • negative regulation of cardiac muscle cell differentiation
  • chromatin modification
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • regulation of protein stability
Components
  • cytoplasm
  • nucleus
  • plasma membrane
  • spindle microtubule
  • histone deacetylase complex
  • Golgi apparatus
  • cytosol
  • transcriptional repressor complex
  • nucleoplasm
General FunctionTranscription factor binding
Specific FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2326173
UniProtKB IDO15379
UniProtKB Entry NameHDAC3_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021323|Histone deacetylase 3 (HDAC3)
ATGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCT
GGACACCCTATGAAGCCCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGT
CTCTATAAGAAGATGATCGTCTTCAAGCCATACCAGGCCTCCCAACATGACATGTGCCGC
TTCCACTCCGAGGACTACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGC
TTCACCAAGAGTCTTAATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTC
TTTGAGTTCTGCTCGCGTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAAC
AAGATCTGTGATATTGCCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAG
GCCTCTGGCTTCTGCTATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTAC
CACCCTCGGGTGCTCTACATTGACATTGACATCCACCATGGTGACGGGGTTCAAGAAGCT
TTCTACCTCACTGACCGGGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTC
CCTGGCACAGGTGACATGTATGAAGTCGGGGCAGAGAGTGGCCGCTACTACTGTCTGAAC
GTGCCCCTGCGGGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCGGTTATC
AACCAGGTAGTGGACTTCTACCAACCCACGTGCATTGTGCTCCAGTGTGGAGCTGACTCT
CTGGGCTGTGATCGATTGGGCTGCTTTAACCTCAGCATCCGAGGGCATGGGGAATGCGTT
GAATATGTCAAGAGCTTCAATATCCCTCTACTCGTGCTGGGTGGTGGTGGTTATACTGTC
CGAAATGTTGCCCGCTGCTGGACATATGAGACATCGCTGCTGGTAGAAGAGGCCATTAGT
GAGGAGCTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGACTTCACACTTCATCCA
GATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTGGACCAGATCCGCCAG
ACAATCTTTGAAAACCTGAAGATGCTGAACCATGCACCTAGTGTCCAGATTCATGACGTG
CCTGCAGACCTCCTGACCTATGACAGGACTGATGAGGCTGATGCAGAGGAGAGGGGTCCT
GAGGAGAACTATAGCAGGCCAGAGGCACCCAATGAGTTCTATGATGGAGACCATGACAAT
GACAAGGAAAGCGATGTGGAGATTTAA
GenBank Gene IDU66914
GeneCard IDNot Available
GenAtlas IDHDAC3
HGNC IDHGNC:4854
Chromosome Location5
Locus5q31
References
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