NameChloride intracellular channel protein 2
Synonyms
  • XAP121
Gene NameCLIC2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009047|Chloride intracellular channel protein 2
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEE
LKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKF
SAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLT
LADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYA
NVAKQKS
Number of residues247
Molecular Weight28356.1
Theoretical pINot Available
GO Classification
Functions
  • voltage-gated ion channel activity
  • chloride channel activity
  • glutathione peroxidase activity
Processes
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
  • transport
  • signal transduction
  • oxidation-reduction process
  • chloride transmembrane transport
  • positive regulation of binding
  • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
  • negative regulation of ryanodine-sensitive calcium-release channel activity
Components
  • intracellular
  • cytoplasm
  • nucleus
  • chloride channel complex
General FunctionVoltage-gated ion channel activity
Specific FunctionCan insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
Pfam Domain Function
Transmembrane Regions32-52
GenBank Protein IDNot Available
UniProtKB IDO15247
UniProtKB Entry NameCLIC2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013583|Chloride intracellular channel protein 2 (CLIC2)
ATGTCAGGCCTGCGGCCCGGCACTCAAGTGGACCCTGAGATTGAGCTTTTTGTAAAGGCT
GGAAGTGATGGAGAGAGTATTGGAAACTGTCCCTTTTGCCAACGCCTTTTCATGATCCTC
TGGCTTAAAGGAGTTAAATTTAATGTGACAACTGTTGACATGACCAGAAAGCCTGAAGAA
CTAAAGGACTTAGCCCCAGGTACCAATCCTCCGTTCCTGGTGTATAACAAGGAGTTGAAA
ACAGACTTCATTAAAATTGAGGAGTTTTTAGAACAAACCCTGGCTCCTCCAAGGTACCCT
CACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTT
TCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTC
AAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCA
GACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACA
CTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATAT
CGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTAT
GCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCA
AATGTGGCTAAACAGAAGAGTTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2063
Chromosome LocationX
LocusNot Available
References
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