DNA-directed RNA polymerases I and III subunit RPAC1

NameDNA-directed RNA polymerases I and III subunit RPAC1
Synonyms
  • AC40
  • DNA-directed RNA polymerase I subunit C
  • DNA-directed RNA polymerases I and III 40 kDa polypeptide
  • POLR1E
  • RPA39
  • RPA40
  • RPC40
Gene NamePOLR1C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009193|DNA-directed RNA polymerases I and III subunit RPAC1
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD
Number of residues346
Molecular Weight39249.375
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
  • DNA-directed RNA polymerase activity
Processes
  • innate immune response
  • negative regulation of gene expression, epigenetic
  • regulation of gene expression, epigenetic
  • positive regulation of type I interferon production
  • termination of RNA polymerase I transcription
  • termination of RNA polymerase III transcription
  • transcription elongation from RNA polymerase I promoter
  • transcription elongation from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase III promoter
  • transcription initiation from RNA polymerase I promoter
  • gene expression
Components
  • cytosol
  • nucleoplasm
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO15160
UniProtKB Entry NameRPAC1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021441|DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C)
ATGGCGGCTTCTCAGGCGGTGGAGGAAATGCGGAGCCGCGTGGTTCTGGGGGAGTTTGGG
GTTCGCAATGTCCATACTACTGACTTTCCCGGTAACTATTCCGGTTATGATGATGCCTGG
GACCAGGACCGCTTCGAGAAGAATTTCCGTGTGGATGTAGTACACATGGATGAAAACTCA
CTGGAGTTTGACATGGTGGGAATTGACGCAGCCATTGCCAATGCTTTTCGACGAATTCTG
CTAGCTGAGGTGCCAACTATGGCTGTGGAGAAGGTCCTGGTGTACAATAATACATCCATT
GTTCAGGATGAGATTCTTGCTCACCGTCTGGGGCTCATTCCCATTCATGCTGATCCCCGT
CTTTTTGAGTATCGGAACCAAGGAGATGAAGAAGGCACAGAGATAGATACTCTACAGTTT
CGTCTCCAGGTCAGATGCACTCGGAACCCCCATGCTGCTAAAGATTCCTCTGACCCCAAC
GAACTGTACGTGAACCACAAAGTGTATACCAGGCATATGACATGGATCCCCCTGGGGAAC
CAGGCTGATCTCTTTCCAGAGGGCACTATCCGACCAGTGCATGATGATATCCTCATCGCT
CAGCTGCGGCCTGGCCAAGAAATTGACCTGCTCATGCACTGTGTCAAGGGCATTGGCAAA
GATCATGCCAAGTTTTCACCAGTGGCAACAGCCAGTTACAGGCTCCTGCCAGACATCACC
CTGCTTGAGCCCGTGGAAGGGGAGGCAGCTGAGGAGTTGAGCAGGTGCTTCTCACCTGGT
GTTATTGAGGTGCAGGAAGTCCAAGGTAAAAAGGTGGCCAGAGTTGCCAACCCCCGGCTG
GATACCTTCAGCAGAGAAATCTTCCGGAATGAGAAGCTAAAGAAGGTTGTGAGGCTTGCC
CGGGTTCGAGATCATTATATCTTCTCTGTTGAGTCAACGGGGGTGTTGCCACCAGATGTG
CTGGTGAGTGAAGCCATCAAAGTACTGATGGGGAAGTGCCGGCGCTTCTTGGATGAACTA
GATGCGGTTCAGATGGACTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:20194
Chromosome Location6
LocusNot Available
References
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