Aurora kinase A

NameAurora kinase A
Synonyms
  • 2.7.11.1
  • AIK
  • AIRK1
  • ARK-1
  • ARK1
  • AURA
  • Aurora 2
  • Aurora-related kinase 1
  • Aurora/IPL1-related kinase 1
  • AYK1
  • Breast tumor-amplified kinase
  • BTAK
  • hARK1
  • IAK1
  • Serine/threonine-protein kinase 15
  • Serine/threonine-protein kinase 6
  • Serine/threonine-protein kinase aurora-A
  • STK15
  • STK6
Gene NameAURKA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001973|Aurora kinase A
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Number of residues403
Molecular Weight45809.03
Theoretical pI9.9
GO Classification
Functions
  • protein kinase binding
  • protein serine/threonine/tyrosine kinase activity
  • ATP binding
  • protein kinase activity
  • protein serine/threonine kinase activity
  • histone serine kinase activity
Processes
  • regulation of centrosome cycle
  • protein localization to centrosome
  • regulation of protein stability
  • mitotic nuclear division
  • anterior/posterior axis specification
  • response to estradiol
  • positive regulation of oocyte maturation
  • negative regulation of protein binding
  • negative regulation of apoptotic process
  • protein phosphorylation
  • centrosome localization
  • G2/M transition of mitotic cell cycle
  • mitotic centrosome separation
  • mitotic cell cycle
  • spindle assembly involved in female meiosis I
  • mitotic spindle organization
  • positive regulation of mitotic nuclear division
  • spindle stabilization
  • protein autophosphorylation
  • regulation of cytokinesis
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • cell division
  • neuron projection extension
Components
  • cilium
  • cytosol
  • mitotic spindle
  • perinuclear region of cytoplasm
  • meiotic spindle
  • germinal vesicle
  • axon hillock
  • pronucleus
  • midbody
  • spindle
  • centriole
  • spindle midzone
  • microtubule cytoskeleton
  • chromosome passenger complex
  • microtubule
  • condensed nuclear chromosome, centromeric region
  • nucleus
  • spindle pole centrosome
  • centrosome
General FunctionProtein serine/threonine/tyrosine kinase activity
Specific FunctionMitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2641948
UniProtKB IDO14965
UniProtKB Entry NameAURKA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016278|Aurora kinase A (AURKA)
ATGGACCGATCTAAAGAAAACTGCATTTCAGGACCTGTTAAGGCTACAGCTCCAGTTGGA
GGTCCAAAACGTGTTCTCGTGACTCAGCAATTTCCTTGTCAGAATCCATTACCTGTAAAT
AGTGGCCAGGCTCAGCGGGTCTTGTGTCCTTCAAATTCTTCCCAGCGCATTCCTTTGCAA
GCACAAAAGCTTGTCTCCAGTCACAAGCCGGTTCAGAATCAGAAGCAGAAGCAATTGCAG
GCAACCAGTGTACCTCATCCTGTCTCCAGGCCACTGAATAACACCCAAAAGAGCAAGCAG
CCCCTGCCATCGGCACCTGAAAATAATCCTGAGGAGGAACTGGCATCAAAACAGAAAAAT
GAAGAATCAAAAAAGAGGCAGTGGGCTTTGGAAGACTTTGAAATTGGTCGCCCTCTGGGT
AAAGGAAAGTTTGGTAATGTTTATTTGGCAAGAGAAAAGCAAAGCAAGTTTATTCTGGCT
CTTAAAGTGTTATTTAAAGCTCAGCTGGAGAAAGCCGGAGTGGAGCATCAGCTCAGAAGA
GAAGTAGAAATACAGTCCCACCTTCGGCATCCTAATATTCTTAGACTGTATGGTTATTTC
CATGATGCTACCAGAGTCTACCTAATTCTGGAATATGCACCACTTGGAACAGTTTATAGA
GAACTTCAGAAACTTTCAAAGTTTGATGAGCAGAGAACTGCTACTTATATAACAGAATTG
GCAAATGCCCTGTCTTACTGTCATTCGAAGAGAGTTATTCATAGAGACATTAAGCCAGAG
AACTTACTTCTTGGATCAGCTGGAGAGCTTAAAATTGCAGATTTTGGGTGGTCAGTACAT
GCTCCATCTTCCAGGAGGACCACTCTCTGTGGCACCCTGGACTACCTGCCCCCTGAAATG
ATTGAAGGTCGGATGCATGATGAGAAGGTGGATCTCTGGAGCCTTGGAGTTCTTTGCTAT
GAATTTTTAGTTGGGAAGCCTCCTTTTGAGGCAAACACATACCAAGAGACCTACAAAAGA
ATATCACGGGTTGAATTCACATTCCCTGACTTTGTAACAGAGGGAGCCAGGGACCTCATT
TCAAGACTGTTGAAGCATAATCCCAGCCAGAGGCCAATGCTCAGAGAAGTACTTGAACAC
CCCTGGATCACAGCAAATTCATCAAAACCATCAAATTGCCAAAACAAAGAATCAGCTAGC
AAACAGTCTTAG
GenBank Gene IDD84212
GeneCard IDNot Available
GenAtlas IDAURKA
HGNC IDHGNC:11393
Chromosome Location20
Locus20q13.2-q13.3
References
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