T3DB: Chromodomain-helicase-DNA-binding protein 1

Name	Chromodomain-helicase-DNA-binding protein 1
Synonyms	3.6.4.12 ATP-dependent helicase CHD1 CHD-1
Gene Name	CHD1
Organism	Human
Amino acid sequence	>lcl\|BSEQ0037040\|Chromodomain-helicase-DNA-binding protein 1 MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS QSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNS GSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETES DYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNV SYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEAD GDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETK RWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSE CSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLE LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLS TLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDK AFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFI MPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSA LQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEAL QHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKG ELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPF NKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFK VANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQI SFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKK FGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGP TFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSN LLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRER SKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSE REQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHA IKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDR HQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLE GSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLD QRSPYGSRSPFEHSVEHKSTPEHTWSSRKT
Number of residues	1710
Molecular Weight	196685.865
Theoretical pI	7.17
GO Classification	Functions ATP binding DNA binding ATP-dependent DNA helicase activity methylated histone binding Processes transcription, DNA-templated regulation of transcription from RNA polymerase II promoter DNA duplex unwinding chromatin remodeling positive regulation by host of viral transcription Components cytoplasm nucleus
General Function	Methylated histone binding
Specific Function	ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
Pfam Domain Function	Chromo (PF00385 ) Helicase_C (PF00271 ) SNF2_N (PF00176 ) DUF4208 (PF13907 )
Transmembrane Regions	Not Available
GenBank Protein ID	2645429
UniProtKB ID	O14646
UniProtKB Entry Name	CHD1_HUMAN
Cellular Location	Nucleus
Gene sequence	>lcl\|BSEQ0018968\|Chromodomain-helicase-DNA-binding protein 1 (CHD1) ATGAATGGACACAGTGATGAAGAAAGTGTTAGAAACAGTAGTGGAGAATCAAGCCAGTCG GATGATGATTCTGGGTCAGCTTCAGGCTCTGGATCTGGTTCGAGTTCTGGAAGCAGTAGT GATGGAAGCAGTAGCCAGTCAGGTAGCAGTGACTCTGACTCCGGATCTGAATCAGGCAGT CAGTCAGAGTCTGAGTCAGACACTTCCCGAGAAAACAAAGTTCAAGCAAAACCACCGAAA GTTGATGGAGCTGAGTTTTGGAAATCTAGTCCTAGTATTCTGGCCGTTCAGAGATCTGCA ATCCTCAAGAAGCAGCAACAGCAGCAGCAGCAACAACAACATCAAGCCTCATCTAATAGC GGATCAGAAGAGGATTCCTCTAGCAGTGAAGATTCCGATGACTCATCAAGTGAGGTCAAA AGGAAAAAGCATAAAGATGAAGATTGGCAAATGTCTGGGTCAGGATCTCCATCTCAGTCT GGTTCAGATTCAGAATCTGAAGAAGAGAGAGAGAAAAGCAGTTGTGATGAAACAGAATCT GATTATGAGCCAAAAAACAAAGTCAAAAGCAGAAAACCTCAAAATAGATCTAAGTCAAAA AATGGAAAGAAGATTCTTGGACAAAAAAAGAGACAGATTGATTCATCTGAGGAGGATGAT GATGAAGAAGATTATGATAATGATAAAAGAAGTTCTCGTCGCCAAGCAACTGTTAATGTT AGCTATAAGGAGGATGAAGAAATGAAAACAGATTCTGATGACCTACTGGAAGTCTGTGGA GAGGATGTTCCTCAACCTGAGGAAGAGGAATTTGAAACCATAGAAAGATTTATGGATTGT CGGATTGGGAGAAAAGGAGCTACTGGTGCTACTACAACCATCTATGCAGTTGAAGCAGAT GGTGACCCAAATGCAGGCTTTGAAAAAAACAAAGAACCAGGAGAGATTCAGTATTTAATT AAATGGAAAGGATGGTCCCATATCCACAACACTTGGGAGACAGAAGAAACCCTCAAGCAG CAGAATGTTAGAGGAATGAAAAAATTGGATAATTATAAGAAAAAAGATCAGGAAACAAAA AGATGGTTGAAAAATGCCTCTCCAGAAGATGTGGAATATTATAATTGCCAGCAAGAACTT ACAGATGATCTACATAAACAGTATCAAATAGTGGAACGTATAATTGCTCATTCCAATCAA AAGTCAGCAGCTGGTTATCCTGATTATTACTGCAAATGGCAGGGCCTTCCATACTCAGAG TGCAGCTGGGAAGATGGAGCTCTCATTTCCAAAAAGTTTCAAGCATGCATTGATGAGTAT TTTAGCAGGAACCAATCAAAAACCACTCCTTTTAAAGATTGCAAAGTATTAAAACAAAGG CCAAGGTTTGTAGCCCTGAAGAAGCAGCCATCCTATATTGGAGGACATGAGGGCTTAGAA TTAAGAGATTATCAACTGAATGGTTTAAATTGGCTTGCTCATTCTTGGTGCAAAGGAAAT AGTTGCATACTCGCTGATGAAATGGGCCTTGGAAAAACAATACAGACGATCTCATTTCTG AATTATTTGTTTCATGAACATCAATTATATGGACCTTTTTTATTGGTAGTACCGCTCTCC ACTCTTACTTCCTGGCAAAGGGAAATTCAGACTTGGGCTTCTCAAATGAATGCTGTGGTT TATTTAGGTGACATTAACAGCAGAAACATGATAAGAACTCATGAATGGACGCATCATCAG ACCAAACGGTTAAAATTTAATATATTGTTAACAACTTATGAAATTTTATTAAAAGATAAG GCATTCCTTGGAGGTCTAAATTGGGCATTTATAGGTGTTGATGAAGCACACCGATTAAAG AATGATGACTCCCTTCTGTATAAAACTTTAATAGATTTTAAATCCAATCATCGTCTCCTT ATCACTGGAACTCCTCTACAGAATTCCCTCAAAGAGCTCTGGTCTTTGCTACATTTCATT ATGCCAGAAAAGTTTTCTTCCTGGGAAGATTTTGAAGAAGAACATGGCAAAGGGAGAGAA TATGGTTATGCAAGCCTTCACAAGGAGCTTGAGCCATTTCTGTTACGCCGAGTTAAGAAA GATGTGGAAAAATCTCTTCCTGCCAAGGTTGAGCAGATTTTAAGAATGGAAATGAGTGCT TTACAGAAACAATATTACAAATGGATTTTAACTAGGAATTACAAAGCCCTCAGCAAAGGT TCCAAGGGCAGTACCTCAGGCTTTTTGAACATTATGATGGAGCTAAAGAAATGTTGTAAC CATTGCTACCTCATTAAACCACCAGATAATAATGAATTCTATAATAAACAGGAGGCCTTA CAACACTTAATTCGTAGTAGCGGAAAATTGATTCTTCTTGACAAGCTATTAATTCGCCTA AGAGAACGAGGCAATCGAGTTCTTATTTTTTCACAAATGGTGCGGATGTTAGATATACTT GCAGAATATTTGAAATATCGTCAATTCCCCTTTCAAAGATTAGATGGATCAATAAAAGGA GAACTGAGGAAACAAGCTCTAGATCATTTTAATGCTGAGGGATCAGAGGATTTTTGCTTT TTGCTGTCCACAAGAGCTGGAGGTCTAGGGATTAATTTAGCCTCTGCTGACACTGTTGTT ATATTTGATTCCGATTGGAATCCACAGAATGATCTTCAGGCACAGGCTAGAGCCCATCGA ATTGGGCAAAAGAAACAGGTGAATATTTATCGTCTAGTTACAAAGGGATCAGTTGAAGAA GATATTCTTGAAAGGGCGAAAAAGAAGATGGTTTTAGATCATCTTGTAATTCAAAGAATG GACACAACTGGGAAGACAGTACTACATACAGGTTCTGCCCCATCAAGTTCTACTCCTTTC AATAAAGAAGAGTTATCAGCCATTTTAAAGTTTGGTGCTGAAGAACTTTTTAAGGAACCT GAAGGAGAAGAACAAGAGCCCCAGGAAATGGATATAGATGAAATCTTGAAGAGAGCTGAA ACTCATGAAAATGAACCAGGTCCTTTAACTGTAGGAGATGAATTGCTTTCCCAGTTCAAG GTTGCCAACTTCTCAAATATGGATGAGGATGACATTGAGTTGGAACCTGAAAGAAATTCA AAGAATTGGGAGGAAATTATTCCAGAAGATCAAAGAAGACGATTAGAAGAAGAAGAAAGA CAAAAGGAACTTGAAGAAATTTATATGCTCCCAAGAATGAGAAATTGTGCAAAACAGATT AGTTTCAATGGAAGTGAAGGGAGGCGCAGTAGAAGTAGGAGATACTCTGGATCTGATAGT GATTCCATCTCAGAAGGGAAAAGGCCAAAGAAACGTGGAAGACCACGGACTATTCCTCGG GAGAATATTAAAGGATTTAGTGATGCAGAAATTAGGCGGTTTATCAAGAGCTATAAGAAA TTTGGTGGTCCTCTGGAAAGATTAGATGCAATTGCTCGAGATGCTGAGTTAGTTGATAAG TCAGAAACAGACCTTAGACGACTGGGAGAATTGGTACATAATGGTTGCATTAAAGCATTA AAGGATAGTTCTTCAGGAACAGAACGAACAGGTGGTAGACTCGGAAAAGTGAAGGGTCCA ACATTCCGAATATCAGGAGTACAGGTGAATGCCAAACTAGTCATCTCCCATGAAGAAGAA TTAATACCTTTGCACAAATCCATTCCTTCTGATCCAGAAGAAAGAAAGCAGTATACTATC CCATGCCACACAAAGGCAGCTCATTTTGATATAGACTGGGGCAAAGAAGATGATTCCAAT TTGTTAATTGGCATCTATGAATATGGATATGGAAGCTGGGAAATGATTAAAATGGATCCT GACCTCAGTCTAACACACAAGATTCTTCCAGATGATCCCGATAAAAAACCACAAGCAAAA CAGTTGCAGACCCGTGCAGACTACCTCATCAAATTACTTAGTAGAGATCTTGCAAAAAAA GAAGCTCTTTCTGGTGCGGGAAGTTCAAAGAGGAGAAAAGCAAGAGCTAAGAAGAATAAA GCAATGAAGTCTATAAAAGTGAAAGAGGAAATAAAGAGTGATTCTTCTCCTCTGCCTTCA GAGAAGTCTGATGAAGATGATGATAAATTGAGTGAATCCAAGTCTGATGGTAGGGAAAGA TCCAAGAAATCTTCAGTGTCAGATGCTCCAGTTCATATCACGGCAAGTGGTGAACCAGTT CCCATTTCTGAAGAATCTGAAGAGCTGGATCAGAAGACATTCAGCATTTGTAAAGAAAGA ATGAGGCCTGTTAAAGCAGCTTTGAAACAACTTGATAGGCCTGAGAAAGGCCTTTCAGAA AGAGAACAACTAGAGCATACTAGACAATGTTTAATAAAAATTGGAGACCATATCACAGAA TGTCTAAAAGAGTATACAAATCCTGAACAAATTAAGCAATGGAGAAAAAACCTGTGGATT TTTGTATCTAAGTTTACTGAATTTGATGCAAGAAAATTACATAAATTATATAAGCATGCT ATTAAAAAACGGCAGGAGTCTCAGCAAAACAGTGATCAAAACAGCAACTTGAATCCTCAC GTGATTAGAAATCCAGATGTGGAAAGATTAAAAGAGAATACAAATCACGATGATAGCAGC AGGGACAGTTATTCCTCTGATAGACACTTAACTCAGTACCATGATCATCATAAAGACCGA CATCAGGGAGATTCTTACAAAAAAAGTGATTCCAGGAAAAGACCCTATTCTTCTTTTAGT AATGGTAAAGACCATCGTGATTGGGATCACTACAAGCAAGACAGCAGATATTACAGTGAC AGAGAGAAACACAGAAAACTGGATGATCACAGGAGTAGAGATCACAGGTCAAATTTGGAA GGAAGTTTAAAAGATAGATCTCATTCTGATCATCGTTCTCACTCAGATCATCGGTTACAT TCAGACCACCGGTCAAGTTCTGAATATACGCACCATAAATCTTCCAGGGATTATAGGTAT CACTCAGACTGGCAAATGGACCACAGAGCTTCCAGCAGTGGCCCTAGGTCACCACTAGAT CAGAGATCTCCTTATGGCTCCAGATCTCCATTTGAACATTCAGTTGAACACAAAAGTACA CCGGAGCATACCTGGAGTAGTCGGAAAACATAA
GenBank Gene ID	AF006513
GeneCard ID	Not Available
GenAtlas ID	CHD1
HGNC ID	HGNC:1915
Chromosome Location	5
Locus	5q15-q21
References	Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS: Characterization of the CHD family of proteins. 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