T3DB: Neurocan core protein

Name	Neurocan core protein
Synonyms	Chondroitin sulfate proteoglycan 3 CSPG3 NEUR
Gene Name	NCAN
Organism	Human
Amino acid sequence	>lcl\|BSEQ0020772\|Neurocan core protein MGAPFVWALGLLMLQMLLFVAGEQGTQDITDASERGLHMQKLGSGSVQAALAELVALPCL FTLQPRPSAARDAPRIKWTKVRTASGQRQDLPILVAKDNVVRVAKSWQGRVSLPSYPRRR ANATLLLGPLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVVFHYRSARDRYALTFAEAQE ACRLSSAIIAAPRHLQAAFEDGFDNCDAGWLSDRTVRYPITQSRPGCYGDRSSLPGVRSY GRRNPQELYDVYCFARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQLHLAWHEG LDQCDPGWLADGSVRYPIQTPRRRCGGPAPGVRTVYRFANRTGFPSPAERFDAYCFRAHH PTSQHGDLETPSSGDEGEILSAEGPPVRELEPTLEEEEVVTPDFQEPLVSSGEEETLILE EKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTAASSHTEVAPTDPMPRRR GRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAVTEMLGSGQSRSP WADLTNEVDMPGAGSAGGKSSPEPWLWPPTMVPPSISGHSRAPVLELEKAEGPSARPATP DLFWSPLEATVSAPSPAPWEAFPVATSPDLPMMAMLRGPKEWMLPHPTPISTEANRVEAH GEATATAPPSPAAETKVYSLPLSLTPTGQGGEAMPTTPESPRADFRETGETSPAQVNKAE HSSSSPWPSVNRNVAVGFVPTETATEPTGLRGIPGSESGVFDTAESPTSGLQATVDEVQD PWPSVYSKGLDASSPSAPLGSPGVFLVPKVTPNLEPWVATDEGPTVNPMDSTVTPAPSDA SGIWEPGSQVFEEAESTTLSPQVALDTSIVTPLTTLEQGDKVGVPAMSTLGSSSSQPHPE PEDQVETQGTSGASVPPHQSSPLGKPAVPPGTPTAASVGESASVSSGEPTVPWDPSSTLL PVTLGIEDFELEVLAGSPGVESFWEEVASGEEPALPGTPMNAGAEEVHSDPCENNPCLHG GTCNANGTMYGCSCDQGFAGENCEIDIDDCLCSPCENGGTCIDEVNGFVCLCLPSYGGSF CEKDTEGCDRGWHKFQGHCYRYFAHRRAWEDAEKDCRRRSGHLTSVHSPEEHSFINSFGH ENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFAGGEDCVVMVAHESGRWNDVPC NYNLPYVCKKGTVLCGPPPAVENASLIGARKAKYNVHATVRYQCNEGFAQHHVATIRCRS NGKWDRPQIVCTKPRRSHRMRRHHHHHQHHHQHHHHKSRKERRKHKKHPTEDWEKDEGNF C
Number of residues	1321
Molecular Weight	143092.14
Theoretical pI	Not Available
GO Classification	Functions calcium ion binding carbohydrate binding hyaluronic acid binding Processes chondroitin sulfate biosynthetic process cell adhesion chondroitin sulfate catabolic process dermatan sulfate biosynthetic process small molecule metabolic process carbohydrate metabolic process axon guidance extracellular matrix organization skeletal system development glycosaminoglycan metabolic process central nervous system development chondroitin sulfate metabolic process Components extracellular region Golgi lumen lysosomal lumen proteinaceous extracellular matrix
General Function	Hyaluronic acid binding
Specific Function	May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Pfam Domain Function	EGF (PF00008 ) V-set (PF07686 ) Sushi (PF00084 ) Lectin_C (PF00059 ) Xlink (PF00193 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	O14594
UniProtKB Entry Name	NCAN_HUMAN
Cellular Location	Secreted
Gene sequence	>lcl\|BSEQ0020773\|Neurocan core protein (NCAN) ATGGGGGCCCCGTTTGTCTGGGCCTTGGGCCTTTTGATGCTGCAGATGCTGCTCTTTGTG GCTGGGGAACAGGGCACACAGGATATCACCGATGCCAGCGAAAGGGGGCTCCACATGCAG AAGCTGGGGTCTGGGTCAGTGCAGGCTGCGCTGGCGGAGCTGGTGGCCCTGCCCTGTCTC TTTACCCTGCAGCCACGGCCAAGCGCAGCCCGAGATGCCCCTCGGATAAAGTGGACCAAG GTGCGGACTGCGTCGGGCCAGCGACAGGACTTGCCCATCCTGGTGGCCAAGGACAATGTC GTGAGGGTGGCCAAAAGCTGGCAGGGACGAGTGTCACTGCCTTCCTACCCCCGGCGCCGA GCCAACGCCACGCTACTTCTGGGGCCACTGAGGGCCAGTGACTCTGGGCTGTACCGCTGC CAGGTGGTGAGGGGCATCGAGGATGAGCAGGACCTGGTGCCCTTGGAGGTGACAGGTGTT GTGTTCCACTACCGATCAGCCCGGGACCGCTATGCACTGACCTTCGCTGAGGCCCAGGAG GCCTGCCGTCTCAGCTCAGCCATCATTGCAGCCCCTCGGCATCTACAGGCTGCCTTTGAG GATGGCTTTGACAACTGTGATGCTGGCTGGCTCTCTGACCGCACTGTTCGGTATCCTATC ACCCAGTCCCGTCCTGGTTGCTATGGCGACCGTAGCAGCCTTCCAGGGGTTCGGAGCTAT GGGAGGCGCAACCCACAGGAACTCTACGATGTGTATTGCTTTGCCCGGGAGCTGGGGGGC GAGGTCTTCTACGTGGGCCCGGCCCGCCGCCTGACACTGGCCGGCGCGCGTGCACAGTGC CGCCGCCAGGGTGCCGCGCTGGCCTCGGTGGGACAGCTGCACCTGGCCTGGCATGAGGGC CTGGACCAGTGCGACCCGGGCTGGCTGGCCGACGGCAGCGTGCGCTACCCGATCCAGACG CCGCGCCGGCGCTGCGGGGGCCCAGCCCCGGGCGTGCGCACCGTCTACCGCTTCGCTAAC CGGACCGGCTTCCCCTCACCCGCCGAGCGCTTCGACGCCTACTGCTTCCGAGCTCATCAC CCCACGTCACAACATGGAGACCTAGAGACCCCATCCTCTGGGGATGAGGGGGAGATTCTG TCAGCAGAGGGGCCCCCAGTTAGAGAACTGGAGCCCACCCTGGAGGAGGAAGAGGTGGTC ACCCCTGACTTCCAGGAGCCTCTGGTGTCCAGTGGGGAAGAAGAAACCCTGATTTTGGAG GAGAAGCAGGAGTCTCAACAGACCCTCAGCCCTACCCCTGGGGACCCCATGCTGGCCTCA TGGCCCACTGGGGAAGTGTGGCTAAGCACGGTGGCCCCCAGCCCTAGCGACATGGGGGCA GGCACTGCAGCAAGTTCACACACGGAGGTGGCCCCAACTGACCCTATGCCTAGGAGAAGG GGGCGCTTCAAAGGGTTGAATGGGCGCTACTTCCAGCAGCAGGAACCGGAGCCGGGGCTG CAAGGGGGGATGGAGGCCAGCGCCCAGCCCCCCACCTCAGAGGCTGCAGTGAACCAAATG GAGCCTCCGTTGGCCATGGCAGTCACAGAGATGTTGGGCAGTGGCCAGAGCCGGAGCCCC TGGGCTGATCTGACCAATGAGGTGGATATGCCTGGAGCTGGTTCTGCTGGTGGCAAGAGC TCCCCAGAGCCCTGGCTGTGGCCCCCTACCATGGTCCCACCCAGCATCTCAGGCCACAGC AGGGCCCCTGTCCTGGAGCTAGAGAAAGCCGAGGGCCCCAGTGCCAGGCCAGCCACCCCA GACCTGTTTTGGTCCCCCTTGGAGGCCACTGTCTCAGCTCCCAGCCCTGCCCCCTGGGAG GCATTCCCTGTGGCCACCTCCCCAGATCTCCCTATGATGGCCATGCTGCGTGGTCCCAAA GAGTGGATGCTACCACACCCCACCCCCATCTCCACCGAGGCCAATAGAGTTGAGGCACAT GGTGAGGCCACCGCCACGGCTCCACCCTCCCCTGCTGCAGAGACCAAGGTGTATTCCCTG CCTCTCTCTTTGACCCCAACAGGACAGGGTGGAGAGGCCATGCCCACAACACCTGAGTCC CCCAGGGCAGACTTCAGAGAAACTGGGGAGACCAGCCCTGCTCAGGTCAACAAAGCTGAG CACTCCAGCTCCAGCCCATGGCCTTCTGTAAACAGGAATGTGGCTGTAGGTTTTGTCCCC ACTGAGACTGCCACTGAGCCAACGGGCCTCAGGGGTATCCCGGGGTCTGAGTCTGGGGTC TTCGACACAGCAGAAAGCCCCACTTCTGGCTTGCAGGCCACTGTAGATGAGGTGCAGGAC CCCTGGCCCTCAGTGTACAGCAAAGGGCTGGATGCAAGTTCCCCATCTGCCCCCCTGGGG AGCCCTGGAGTCTTCTTGGTACCCAAAGTCACCCCAAATTTGGAGCCTTGGGTTGCTACA GATGAAGGACCCACTGTGAATCCCATGGATTCCACAGTCACGCCGGCCCCCAGTGATGCT AGTGGAATTTGGGAACCTGGATCCCAGGTGTTTGAAGAAGCCGAAAGCACCACCTTGAGC CCTCAGGTGGCCCTGGATACAAGCATTGTGACGCCCCTCACGACCCTGGAGCAGGGGGAC AAGGTTGGAGTTCCAGCCATGTCTACACTGGGCTCCTCAAGCTCCCAACCCCACCCAGAG CCAGAGGATCAGGTGGAGACCCAGGGAACATCAGGAGCTTCAGTGCCTCCGCATCAGAGC AGTCCCCTAGGGAAACCGGCTGTTCCTCCTGGGACACCGACTGCAGCCAGTGTGGGCGAG TCTGCCTCAGTTTCCTCAGGGGAGCCTACGGTACCGTGGGACCCCTCCAGCACCCTGCTG CCTGTCACCCTGGGCATAGAGGACTTCGAACTGGAGGTCCTGGCAGGGAGCCCGGGTGTA GAGAGCTTCTGGGAGGAGGTGGCAAGTGGAGAGGAGCCAGCCCTGCCAGGGACCCCTATG AATGCAGGTGCGGAGGAGGTGCACTCAGATCCCTGTGAGAACAACCCTTGTCTTCATGGA GGGACATGTAATGCCAATGGCACCATGTATGGCTGTAGCTGTGATCAGGGCTTCGCCGGG GAGAACTGTGAGATTGACATTGATGACTGCCTCTGCAGCCCCTGTGAGAATGGAGGCACC TGTATTGATGAGGTCAATGGCTTTGTCTGCCTTTGCCTCCCCAGCTATGGGGGCAGCTTT TGTGAGAAAGACACCGAGGGCTGTGACCGCGGCTGGCATAAGTTCCAGGGCCACTGTTAC CGCTATTTTGCCCACCGGAGGGCATGGGAAGATGCCGAGAAGGACTGCCGCCGCCGCTCC GGCCACCTGACCAGCGTCCACTCACCGGAGGAACACAGCTTCATTAATAGCTTTGGGCAT GAAAACACGTGGATCGGCCTGAACGACAGGATCGTGGAGAGAGATTTCCAGTGGACGGAC AACACCGGGCTGCAATTTGAGAACTGGCGAGAGAACCAGCCGGACAATTTCTTCGCGGGT GGCGAGGACTGTGTGGTGATGGTGGCGCATGAAAGCGGGCGCTGGAACGATGTCCCCTGC AACTACAACCTACCCTATGTCTGCAAGAAGGGCACAGTGCTCTGTGGTCCCCCTCCGGCA GTGGAGAATGCCTCACTCATCGGTGCCCGCAAGGCCAAGTACAATGTCCATGCCACTGTA AGGTACCAGTGCAATGAAGGATTTGCCCAGCACCATGTGGCCACCATTCGATGCCGGAGC AATGGCAAGTGGGACAGGCCCCAAATTGTCTGCACCAAACCCAGACGTTCACATCGGATG CGGCGACACCACCACCACCACCAACACCACCACCAGCATCACCACCACAAATCCCGCAAG GAGCGCAGAAAACACAAGAAACACCCAACGGAGGACTGGGAGAAGGACGAAGGGAATTTC TGCTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:2465
Chromosome Location	19
Locus	Not Available
References	Prange CK, Pennacchio LA, Lieuallen K, Fan W, Lennon GG: Characterization of the human neurocan gene, CSPG3. Gene. 1998 Oct 23;221(2):199-205. 9795216 Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. 15057824 Halim A, Ruetschi U, Larson G, Nilsson J: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. J Proteome Res. 2013 Feb 1;12(2):573-84. doi: 10.1021/pr300963h. Epub 2013 Jan 11. 23234360