NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

NameNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Synonyms
  • 1.6.5.3
  • CI-23kD
  • Complex I-23kD
  • NADH-ubiquinone oxidoreductase 23 kDa subunit
  • TYKY subunit
Gene NameNDUFS8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009891|NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLL
WTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAI
CPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEE
LLYNKEKLLNNGDKWEAEIAANIQADYLYR
Number of residues210
Molecular Weight23704.795
Theoretical pI6.27
GO Classification
Functions
  • metal ion binding
  • 4 iron, 4 sulfur cluster binding
  • NADH dehydrogenase (ubiquinone) activity
Processes
  • mitochondrial electron transport, NADH to ubiquinone
  • response to oxidative stress
  • small molecule metabolic process
  • cellular metabolic process
  • mitochondrial respiratory chain complex I assembly
  • respiratory electron transport chain
Components
  • mitochondrial matrix
  • mitochondrial respiratory chain complex I
  • mitochondrion
General FunctionNadh dehydrogenase (ubiquinone) activity
Specific FunctionCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1935056
UniProtKB IDO00217
UniProtKB Entry NameNDUS8_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0009892|NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (NDUFS8)
ATGCGCTGCCTGACCACGCCTATGCTGCTGCGGGCCCTGGCCCAGGCTGCACGTGCAGGA
CCTCCTGGTGGCCGGAGCCTCCACAGCAGTGCAGTGGCAGCCACCTACAAGTATGTGAAC
ATGCAGGATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTG
TGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTGAGCTACCTGTTCCGGGAACCGGCC
ACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCG
CTGCGCCGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATC
TGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCAAGAGCTGATGGCAGCCGCCGGACC
ACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGT
CCCGTGGATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAG
CTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGGGACAAGTGGGAGGCCGAGATCGCC
GCCAACATCCAGGCTGACTACTTGTATCGGTGA
GenBank Gene IDU65579
GeneCard IDNot Available
GenAtlas IDNDUFS8
HGNC IDHGNC:7715
Chromosome Location11
Locus11q13
References
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  2. de Sury R, Martinez P, Procaccio V, Lunardi J, Issartel JP: Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase. Gene. 1998 Jul 17;215(1):1-10. 9666055
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