Rho-related GTP-binding protein RhoD

NameRho-related GTP-binding protein RhoD
Synonyms
  • ARHD
  • Rho-related protein HP1
  • RhoHP1
Gene NameRHOD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019719|Rho-related GTP-binding protein RhoD
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQV
KGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCK
KVPIIVVGCKTDLCKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVH
AVFQEAAEVALSSRGRNFWRRITQGFCVVT
Number of residues210
Molecular Weight23412.695
Theoretical pINot Available
GO Classification
Functions
  • GTP binding
  • GTPase activity
Processes
  • lamellipodium assembly
  • actin filament bundle assembly
  • small GTPase mediated signal transduction
  • protein targeting
  • regulation of actin cytoskeleton reorganization
  • positive regulation of cell migration
  • Rho protein signal transduction
  • positive regulation of cell adhesion
  • focal adhesion assembly
  • regulation of small GTPase mediated signal transduction
  • regulation of focal adhesion assembly
Components
  • plasma membrane
  • cytosol
  • early endosome
  • endosome membrane
General FunctionGtpase activity
Specific FunctionInvolved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO00212
UniProtKB Entry NameRHOD_HUMAN
Cellular LocationCell membrane
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:670
Chromosome LocationNot Available
LocusNot Available
References
  1. Shimizu F, Watanabe TK, Okuno S, Omori Y, Fujiwara T, Takahashi E, Nakamura Y: Isolation of a novel human cDNA (rhoHP1) homologous to rho genes. Biochim Biophys Acta. 1997 Mar 20;1351(1-2):13-6. 9116026
  2. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. 16554811
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  4. Gasman S, Kalaidzidis Y, Zerial M: RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase. Nat Cell Biol. 2003 Mar;5(3):195-204. 12577064
  5. Wu X, Frost JA: Multiple Rho proteins regulate the subcellular targeting of PAK5. Biochem Biophys Res Commun. 2006 Dec 15;351(2):328-35. Epub 2006 Oct 17. 17064668
  6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648
  7. Gad AK, Nehru V, Ruusala A, Aspenstrom P: RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Mol Biol Cell. 2012 Dec;23(24):4807-19. doi: 10.1091/mbc.E12-07-0555. Epub 2012 Oct 19. 23087206
  8. Nehru V, Almeida FN, Aspenstrom P: Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. Biochem Biophys Res Commun. 2013 Apr 5;433(2):163-9. doi: 10.1016/j.bbrc.2013.02.046. Epub 2013 Feb 26. 23454120
  9. Nehru V, Voytyuk O, Lennartsson J, Aspenstrom P: RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. Traffic. 2013 Dec;14(12):1242-54. doi: 10.1111/tra.12121. Epub 2013 Oct 10. 24102721