Lysine-specific demethylase 4E

NameLysine-specific demethylase 4E
Synonyms
  • 1.14.11.-
  • KDM4D-like protein
  • KDM4DL
  • Lysine-specific demethylase 4D-like
Gene NameKDM4E
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020895|Lysine-specific demethylase 4E
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
Number of residues506
Molecular Weight56803.925
Theoretical pINot Available
GO Classification
Functions
  • dioxygenase activity
  • metal ion binding
Processes
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • chromatin modification
Components
  • nucleus
General FunctionMetal ion binding
Specific FunctionHistone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDB2RXH2
UniProtKB Entry NameKDM4E_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020896|Lysine-specific demethylase 4E (KDM4E)
ATGAAGTCTGTGCACTCCAGTCCCCAGAACACGAGTCATACCATCATGACGTTTTACCCA
ACCATGGAAGAATTTGCAGATTTCAACACATATGTTGCTTACATGGAGTCCCAAGGCGCA
CATCAAGCTGGCCTTGCCAAGGTAATTCCACCCAAGGAATGGAAAGCCAGACAGATGTAT
GATGATATCGAAGACATCTTAATAGCCACTCCCCTCCAGCAGGTGACCTCTGGGCAGGGA
GGTGTGTTTACTCAATACCATAAAAAGAAGAAAGCCATGAGGGTGGGGCAGTATCGCCGC
TTGGCAAACAGTAAAAAATATCAGACTCCGCCACACCAGAATTTTGCAGATTTGGAGCAA
CGATACTGGAAGAGCCACCCCGGTAATCCACCAATTTATGGTGCTGATATCAGCGGCTCC
TTATTTGAAGAAAGCACTAAACAATGGAACCTAGGACACCTGGGAACAATTCTGGACCTG
TTGGAGCAGGAATGTGGGGTTGTCATCGAGGGTGTCAACACACCCTACCTGTACTTTGGC
ATGTGGAAGACCACGTTTGCCTGGCACACAGAGGACATGGACCTTTACAGCATCAACTAC
CTGCACTTTGGGGAGCCCAAAACTTGGTACGTGGTGCCCCCAGAACATGGTCAGCACCTG
GAACGCCTGGCCAGGGAGCTCTTCCCAGACATTTCTCGGGGCTGTGAGGCCTTCCTGCGG
CACAAAGTGGCCCTCATCTCGCCTACAGTTCTCAAGGAAAATGGGATTCCCTTCAATTGC
ATGACTCAGGAGGCTGGGGAGTTCATGGTGACCTTTCCCTATGGCTACCATGCTGGCTTC
AATCACGGCTTCAACTGCGCAGAAGCCATTAATTTTGCCACTCCACGATGGATTGATTAT
GGCAAAATGGCCTCTCAGTGTAGCTGTGGGGAGTCGACAGTGACCTTTTCCATGGACCCC
TTTGTGCGCATTGTGCAACCCGAGAGTTATGAGCTCTGGAAACACAGGCAAGACTTGGCC
ATTGTGGAACACACAGAGCCCAGGGTTGCAGAAAGCCAAGAGCTGAGCAACTGGAGAGAT
GATATAGTACTTAGAAGAGCTGCTCTGGGCCTGAGGCTTCTCCCAAACCTCACAGCCCAG
TGTCCCACACAGCCTGTGTCCTCAGGGCACTGTTACAACCCAAAAGGCTGTGGCACTGAT
GCTGTGCCTGGATCCGCATTCCAAAGCTCTGCATATCATACCCAGACCCAGTCACTTACC
CTGGGGATGTCAGCCAGGGTTCTTCTCCCTTCCACTGGAAGCTGGGGTTCTGGTCGTGGT
CGTGGTCGTGGTCAAGGTCAAGGTCGAGGTTGCAGTCGTGGTCGTGGTCATGGTTGTTGT
ACTCGAGAACTGGGGACTGAGGAGCCAACTGTTCAGCCTGCATCCAAGAGGCGCCTTTTA
ATGGGTACAAGGAGTAGAGCTCAAGGCCACAGGCCTCAGCTCCCGCTTGCCAATGATTTG
ATGACAAATCTGTCCCTTTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:37098
Chromosome Location11
LocusNot Available
References
  1. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. 16554811
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  3. Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U: Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem. 2011 Dec 2;286(48):41616-25. doi: 10.1074/jbc.M111.283689. Epub 2011 Sep 13. 21914792