T3DB: 1,3-beta-glucan synthase component FKS1

Name	1,3-beta-glucan synthase component FKS1
Synonyms	1,3-beta-D-glucan-UDP glucosyltransferase 2.4.1.34 fks1
Gene Name	fksA
Organism	Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Amino acid sequence	>lcl\|BSEQ0013251\|1,3-beta-glucan synthase component FKS1 MSGYPAGHYEDGYGHQEHGGDAYYQDEHGQAYYDPNDYGDSYYDRGNYYNAEGGQAYGQE GGYYDAGHQDDYYGDQYYDQGNGAPRGRRRGDSEEDSETFSDFTMRSETARAADMDYYGR GDERYNSYADSQYAGRGYNGYRPPSSQVSYGANRSSGASTPVYGMDYGSALPGGPRSREP YPAWASDGQVPVSKEEIEDIFIDLVNKFGFQRDSMRNMYDHLMTQLDSRASRMTPNQALL SLHADYIGGDNANYRRWYFAAHLDLDDAVGFANMKLGKADRKTRKARKAAKAAAQQNPEN VEENLEAMEGDNSLEAAVYRWKSRMNRMSPHDRVRQLALYMLCWGEANQVRYMPECICFI FKCADDYYSSPECQSRVEPVEEFTYLNEIITPLYQFCRDQGYEILDGKYVRRERDHEKII GYDDMNQLFWYPEGIERISFEDKTRLVDVPPAERWTKLKDVDWKKAFFKTYRETRSWFHM ITNFNRIWVIHLGAFWFFTAYNAPTLYTKNYQQQLDNKPAGSKYWSAVGFGGALVGLIQI LATLCEWMYVPRRWAGAQHLSKRLMFLIAVFIVNLAPGVVVFGFNNVLSETICLIIGIVH FFIALATFFFFSVMPLGGLFGSYLKKHGRQYVASQTFTASYPRLNGNDMWMSYGLWICVF GAKLVESYFFLTLSLKDPMRILSPMRIHQCAGVTYIPNSLCHAQPQILLGLMMFMDLTLF FLDSYLWYVICNTIFSVARSFYLGVSIWSPWRNIFSRLPKRIYSKVLATTDMEIKYKPKV LISQVWNAIIISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFVSQEDQSFKTEF FPAGSEAERRISFFAQSVATPMPEPLPVDNMPTFTVLIPHYGEKILLSLREIIREDEPYS RVTLLEYLKQLHPHEWDCFVKDTKILADETSQLNGEPEKNEKDAQKSKIDDLPFYCIGFK SAAPEYTLRTRIWSSLRSQTLYRTISGFMNYSRAIKLLYRVENPEVVQMFGGNSEKLERE LERMARRKFKICVSMQRYAKFNKEERENTEFLLRAYPDLQIAYLDEEPPANEGEEPRLYS ALIDGHCELLDNGMRKPKFRIQLSGNPILGDGKSDNQNHSIIFYRGEYIQVIDANQDNYL EECLKIRSVLAEFEELTTDNVSPYTPGIATEAETPVAILGAREYIFSENVGVLGDVAASK EQTFGTLFARTLAQIGGKLHYGHPDFLNGIFMTTRGGISKAQKGLHLNEDIYAGMTALCR GGRIKHCEYFQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYLGTQLPLDRFLSFYY AHPGFHLNNMFIMLSVQMFMIVLINLGALKHETITCRYNSNLPITDPLRPTYCADLTPII AWVNRCVVSIFIVFFISFVPLAVQELTERGLWRMATRLAKHFGSFSFMFEVFVCQIYANA VHQNLSFGGARYIGTGRGFATARIPFGVLYSRFAGPSIYAGSRLLLMLLFATSTVWTPAL IWFWVSLLALCISPFLFNPHQFAWHDFFIDYRDYIRWLSRGNSRSHASSWIAFCRLSRTR LTGYKRKLLGVPSEKGSGDVPRAKFTNIFFSEIIAPLVQVAVTLVPYLYINSRTGISNDN ERASNAVVRIAIVAFGPIGVNAGVSGMFFGMACCMGPIFGMCCKKFGAVLAAIAHAIAVI ILLVIFEVMFFLESWSWPRMVLGMISAAAIQRFIYKLIISLALTREFKHDQSNIAWWTGK WYNMGWHSLSQPGREFLCKITELGYFSADFVLGHILLFVMLPALCIPYVDKFHSVILFWL RPSRQIRPPIYSLKQSKLRKRRVVRFAILYFTMLVLFLILLIAPLVARDEGISVNLNIMS LMQPLDTDNNDTISSYTGNGLPVGYSAWTPSAASASA
Number of residues	1897
Molecular Weight	216972.8
Theoretical pI	Not Available
GO Classification	Functions 1,3-beta-D-glucan synthase activity Processes cell wall organization (1->3)-beta-D-glucan biosynthetic process regulation of cell shape Components 1,3-beta-D-glucan synthase complex mitochondrion integral component of membrane
General Function	1,3-beta-d-glucan synthase activity
Specific Function	Catalytic subunit of the 1,3-beta-glucan synthase. Synthesizes 1,3-beta-glucan, a major structural component of the cell wall. Involved in cell wall synthesis, maintenance and cell wall remodeling (By similarity).
Pfam Domain Function	FKS1_dom1 (PF14288 ) Glucan_synthase (PF02364 )
Transmembrane Regions	487-507 525-545 564-584 591-611 655-675 707-727 728-748 1329-1349 1386-1406 1473-1493 1497-1517 1588-1608 1630-1650 1666-1686 1701-1721 1766-1786 1826-1846
GenBank Protein ID	Not Available
UniProtKB ID	A2QLK4
UniProtKB Entry Name	FKS1_ASPNC
Cellular Location	Mitochondrion
Gene sequence	>lcl\|BSEQ0013252\|1,3-beta-glucan synthase component FKS1 (fksA) ATGTCAGGCTATCCAGCAGGGCATTACGAGGATGGCTACGGCCACCAGGAGCATGGGGGC GATGCGTACTACCAGGACGAACATGGCCAGGCTTATTACGATCCTAACGATTACGGTGAC AGCTATTATGATAGAGGCAATTATTACAACGCAGAAGGAGGTCAGGCATATGGCCAAGAA GGTGGTTACTACGATGCTGGTCACCAGGATGACTACTACGGTGACCAGTACTATGACCAA GGAAATGGTGCCCCCCGCGGAAGACGCCGTGGAGATTCTGAGGAGGATTCGGAGACCTTT AGCGATTTCACCATGAGGTCAGAGACTGCTCGAGCTGCGGATATGGATTACTATGGCCGT GGAGACGAACGTTACAACAGTTATGCCGACAGCCAGTATGCTGGTCGTGGATACAACGGA TACCGGCCGCCATCTTCGCAGGTCTCGTATGGCGCCAACCGATCATCTGGCGCTTCGACA CCCGTATACGGCATGGACTACGGAAGCGCCCTTCCTGGTGGACCGCGTTCTCGGGAGCCG TACCCAGCCTGGGCATCGGATGGTCAGGTCCCTGTCTCCAAGGAGGAAATCGAAGATATC TTCATTGACTTGGTCAACAAATTCGGTTTCCAGAGGGACAGCATGCGCAACATGTATGAC CACCTGATGACACAGTTGGACTCCCGGGCCTCCAGAATGACGCCCAACCAAGCCCTTCTG TCTCTGCACGCAGACTACATTGGTGGTGACAATGCCAACTACCGCCGTTGGTATTTTGCT GCCCATCTGGATTTGGACGATGCCGTGGGATTCGCCAACATGAAGCTGGGCAAAGCAGAC CGGAAGACCAGGAAAGCTCGCAAAGCGGCCAAGGCGGCAGCACAGCAGAACCCTGAAAAC GTCGAGGAGAACCTGGAGGCCATGGAAGGCGACAACAGCCTGGAAGCCGCTGTTTACAGG TGGAAGAGCCGCATGAACCGCATGTCCCCGCATGATCGTGTGCGCCAATTGGCTCTGTAC ATGCTGTGCTGGGGTGAAGCTAACCAGGTCCGGTACATGCCTGAGTGCATTTGCTTCATC TTCAAGTGTGCGGATGATTACTACAGCTCCCCTGAATGCCAGAGCCGGGTTGAGCCGGTG GAGGAATTCACTTACCTGAATGAGATCATTACCCCCCTCTATCAGTTCTGCCGTGACCAG GGTTACGAAATCTTGGATGGCAAGTATGTTCGCCGCGAGCGTGATCACGAGAAGATCATC GGATACGATGATATGAACCAGCTTTTCTGGTACCCCGAGGGTATCGAACGCATCTCATTC GAGGATAAGACTCGTCTTGTCGATGTCCCCCCAGCTGAAAGATGGACCAAGTTGAAGGAC GTCGACTGGAAGAAAGCATTCTTCAAGACGTACAGAGAGACTCGGTCCTGGTTCCACATG ATCACCAACTTCAACCGTATCTGGGTTATTCACCTGGGTGCTTTCTGGTTCTTCACTGCT TATAACGCCCCCACCTTGTATACCAAGAACTACCAGCAGCAGCTGGACAATAAGCCCGCT GGTTCAAAGTATTGGTCTGCTGTCGGTTTTGGTGGTGCCCTGGTTGGATTAATTCAGATC TTGGCAACGCTCTGTGAGTGGATGTACGTGCCTCGCCGGTGGGCAGGTGCTCAGCATCTC AGCAAGCGTCTTATGTTCCTTATCGCCGTTTTCATTGTCAATCTTGCTCCTGGTGTCGTG GTCTTCGGTTTCAACAATGTTCTCAGTGAGACAATCTGCCTCATCATTGGTATCGTCCAC TTCTTCATTGCTCTGGCCACGTTCTTCTTTTTCTCCGTCATGCCTCTTGGAGGTCTGTTC GGCAGTTACCTGAAGAAGCACGGCCGTCAATATGTGGCCAGTCAGACATTCACGGCGAGC TACCCTCGCCTGAATGGCAACGACATGTGGATGTCTTATGGTCTGTGGATCTGTGTTTTC GGTGCGAAGCTGGTCGAGTCTTACTTCTTCCTGACTCTGTCATTGAAGGATCCCATGCGT ATCTTGTCGCCGATGCGTATCCATCAGTGTGCTGGTGTGACATACATCCCGAACAGCCTT TGCCACGCCCAGCCTCAGATTCTGCTGGGTCTGATGATGTTCATGGATTTGACTCTTTTC TTCCTGGATAGTTATCTGTGGTATGTCATTTGTAACACCATCTTCTCGGTGGCTCGGTCC TTCTACCTGGGTGTCTCCATCTGGTCGCCCTGGAGAAACATCTTCTCTCGCCTACCGAAG CGTATCTATTCGAAGGTCTTGGCTACGACCGACATGGAGATCAAGTACAAGCCCAAGGTG CTCATTTCCCAAGTTTGGAACGCCATCATCATCTCCATGTACCGTGAGCATCTGCTGGCG ATTGATCACGTCCAGAAGTTGCTTTACCACCAGGTTCCCTCCGAACAGGAGGGCAAGCGT ACCCTGCGGGCTCCTACCTTCTTCGTTTCGCAGGAAGACCAGTCCTTCAAGACTGAGTTC TTCCCCGCGGGTAGTGAGGCTGAGCGCCGTATCTCCTTCTTTGCCCAGTCGGTCGCTACC CCCATGCCTGAGCCTCTTCCGGTTGACAACATGCCCACTTTCACTGTCCTTATCCCCCAT TACGGAGAGAAGATTCTGCTGTCGTTGCGTGAAATCATTCGTGAGGATGAGCCGTACTCT CGCGTTACTCTCCTGGAATACCTGAAACAGCTCCACCCCCACGAGTGGGACTGCTTCGTC AAGGACACAAAGATTCTGGCTGATGAGACCTCACAACTCAACGGCGAACCCGAGAAGAAC GAGAAGGATGCGCAGAAGAGCAAGATCGACGACCTTCCCTTCTATTGCATCGGTTTCAAG TCTGCCGCTCCCGAATACACGCTCCGTACCCGTATCTGGTCCTCTCTGCGCTCTCAGACC CTGTACAGAACCATTTCCGGTTTCATGAACTACAGCAGGGCCATCAAGCTCCTTTACCGT GTCGAAAACCCCGAGGTCGTCCAGATGTTTGGTGGTAACTCCGAGAAGCTCGAACGTGAG CTTGAAAGGATGGCGCGCCGCAAGTTCAAGATCTGTGTCTCAATGCAACGTTACGCCAAG TTCAACAAGGAAGAGCGTGAAAACACCGAGTTCCTTCTCCGTGCCTACCCTGATCTCCAA ATCGCTTACCTTGACGAGGAACCCCCTGCCAATGAGGGTGAGGAGCCCCGCTTGTACTCG GCTTTGATTGATGGACACTGTGAGCTCCTCGACAACGGAATGCGCAAGCCGAAGTTCAGA ATTCAGCTCTCCGGAAACCCTATCCTGGGTGACGGCAAGTCCGATAACCAGAACCACTCT ATCATCTTCTACCGCGGTGAATACATCCAGGTCATTGACGCTAACCAGGATAACTACCTG GAGGAGTGTCTCAAGATCCGTAGCGTTCTGGCTGAGTTCGAAGAACTTACCACCGACAAT GTCTCGCCCTACACTCCTGGTATTGCCACCGAAGCTGAGACCCCAGTCGCCATTCTCGGT GCTCGTGAATACATTTTCTCTGAGAATGTTGGTGTTCTTGGTGACGTTGCTGCCAGTAAG GAACAGACGTTCGGTACCCTGTTTGCTCGTACCCTTGCGCAGATTGGTGGAAAGCTGCAT TATGGTCACCCTGATTTCCTAAACGGTATCTTCATGACGACGCGTGGTGGTATCTCCAAG GCTCAGAAGGGTCTCCACCTGAACGAGGATATTTATGCTGGTATGACTGCTTTGTGCCGT GGTGGACGCATCAAGCATTGCGAGTACTTCCAGTGTGGTAAGGGTCGTGATTTGGGTTTC GGCTCCATTCTGAACTTCACAACCAAGATTGGTACTGGTATGGGTGAGCAGATGCTGTCC AGAGAGTACTACTATCTCGGAACACAGCTGCCCCTCGATCGCTTCCTGTCTTTCTACTAT GCTCACCCTGGTTTCCATCTTAACAACATGTTCATTATGTTGTCTGTGCAGATGTTCATG ATCGTTCTGATCAACCTTGGTGCTCTGAAGCATGAGACTATTACATGCCGTTACAACTCG AACCTGCCCATTACTGACCCTCTGCGTCCCACGTACTGTGCTGATCTTACCCCCATTATC GCCTGGGTGAACCGTTGCGTCGTTTCCATCTTCATTGTGTTCTTCATCTCCTTCGTTCCC CTGGCCGTCCAGGAATTGACTGAGAGGGGTCTTTGGCGCATGGCTACTCGTCTGGCCAAG CACTTTGGTTCCTTCTCCTTCATGTTCGAGGTGTTTGTCTGCCAAATCTACGCCAATGCT GTTCACCAGAACCTTTCCTTCGGCGGTGCTCGCTACATCGGTACTGGACGTGGTTTCGCT ACGGCTCGTATCCCATTCGGTGTCTTGTACTCCCGTTTCGCTGGACCATCCATCTATGCC GGTTCTCGTTTGCTGCTCATGCTTCTGTTTGCGACATCCACTGTCTGGACACCAGCCCTG ATCTGGTTCTGGGTTTCTCTGCTTGCTCTCTGCATTTCCCCCTTCCTGTTCAACCCCCAC CAGTTTGCTTGGCACGATTTCTTTATCGACTACCGCGATTACATCAGATGGCTGTCCCGT GGTAACTCTCGCTCGCACGCTTCGTCCTGGATCGCCTTCTGCCGCCTGTCTCGTACCCGT CTCACTGGTTACAAGCGCAAGCTTCTTGGTGTTCCTTCGGAGAAGGGATCTGGCGATGTT CCCAGGGCCAAGTTCACGAACATTTTCTTTAGTGAGATCATTGCCCCTCTCGTCCAAGTT GCTGTGACTTTGGTTCCTTACCTCTACATCAACTCGAGAACTGGTATCTCCAATGACAAC GAGCGGGCGTCAAATGCCGTGGTTCGTATTGCCATCGTCGCCTTCGGTCCCATCGGTGTT AACGCCGGTGTCTCGGGTATGTTCTTCGGTATGGCTTGCTGTATGGGTCCCATCTTTGGC ATGTGCTGCAAGAAGTTTGGTGCAGTCCTCGCTGCTATCGCTCACGCCATCGCGGTTATT ATCCTGCTTGTCATTTTCGAGGTCATGTTCTTCCTTGAGAGCTGGTCCTGGCCTCGCATG GTCCTGGGAATGATTTCTGCCGCTGCAATTCAGCGCTTCATCTACAAGCTGATCATCTCC CTCGCCCTGACCAGAGAATTCAAGCATGACCAGTCGAACATCGCTTGGTGGACCGGAAAA TGGTACAACATGGGTTGGCACTCGCTTTCCCAGCCTGGCAGAGAATTCCTGTGCAAGATT ACCGAGCTTGGATACTTCTCTGCCGACTTTGTCCTGGGCCATATTCTCCTCTTTGTCATG CTTCCTGCTCTCTGCATCCCCTATGTTGACAAGTTCCACTCCGTTATCCTCTTCTGGCTG AGGCCTAGTCGTCAAATTCGCCCTCCCATCTACTCTCTGAAGCAGTCTAAGCTCCGCAAG AGAAGAGTTGTCCGATTTGCGATTCTGTATTTCACTATGCTGGTTCTGTTCCTCATCCTT CTCATTGCTCCTCTGGTTGCCCGGGATGAAGGCATCAGCGTGAACCTCAACATCATGAGC CTTATGCAGCCTCTGGATACCGACAATAACGATACCATCTCCAGTTACACTGGTAATGGT CTCCCTGTCGGTTACTCTGCCTGGACCCCGTCCGCGGCGTCTGCATCTGCTTAG
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	Not Available
Chromosome Location	Not Available
Locus	Not Available
References	Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JA, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EG, Debets AJ, Dekker P, van Dijck PW, van Dijk A, Dijkhuizen L, Driessen AJ, d'Enfert C, Geysens S, Goosen C, Groot GS, de Groot PW, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JP, van den Hondel CA, van der Heijden RT, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJ, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NN, Ram AF, Rinas U, Roubos JA, Sagt CM, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJ, Wedler H, Wosten HA, Zeng AP, van Ooyen AJ, Visser J, Stam H: Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat Biotechnol. 2007 Feb;25(2):221-31. Epub 2007 Jan 28. 17259976 Damveld RA, vanKuyk PA, Arentshorst M, Klis FM, van den Hondel CA, Ram AF: Expression of agsA, one of five 1,3-alpha-D-glucan synthase-encoding genes in Aspergillus niger, is induced in response to cell wall stress. Fungal Genet Biol. 2005 Feb;42(2):165-77. Epub 2004 Dec 31. 15670714