Browsing Toxins
Displaying toxin 601 - 625 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0245 | 2-Chlorophenol 95-57-8 | C6H5ClO 128.556 g/mol |  |
| 2-chlorophenol works as a weak uncoupler of oxidative phosphorylation and inhibitors of cellular respiration. The ability of chlorophenols to uncouple oxidative phosph...more Number of Targets: 5 |
| T3D0868 | 4-Chlorophenol 106-48-9 | C6H5ClO 128.556 g/mol |  |
| 4-chlorophenol works as a weak uncoupler of oxidative phosphorylation and inhibitors of cellular respiration. The ability of chlorophenols to uncouple oxidative phosph...more Number of Targets: 3 |
| T3D0139 | Iodine-129 15046-84-1 | I 128.905 g/mol |  |
| Iodide inhibits adenylate cyclase in thyroid gland follicle cells and decreases the TSH-induced rise in intracellular cAMP. This results in decreased iodination of thy...more Number of Targets: 11 |
| T3D1715 | Bromic acid 7789-31-3 | BrHO3 128.910 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D4690 | Dichloroacetic Acid 79-43-6 | C2H2Cl2O2 128.942 g/mol |  |
| The dichloroacetate ion stimulates the activity of the enzyme pyruvate dehydrogenase by inhibiting the enzyme pyruvate dehydrogenase kinase. Thus, it decreases lactate...more Number of Targets: 1 |
| T3D1837 | Selenous acid 7783-00-8 | H2O3Se 128.970 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D2983 | Flucytosine 2022-85-7 | C4H4FN3O 129.093 g/mol |  |
| Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidin...more Number of Targets: 2 |
| T3D4270 | Pyroglutamic acid 98-79-3 | C5H7NO3 129.114 g/mol |  |
| 5-Oxoprolinuria develops in moderate to severe cases of glutathione synthetase deficiency. The deficiency in glutathione synthetase leads to the accumulation of γ-glut...more Number of Targets: 12 |
| T3D1046 | 2-(Nitromethylene)imidazolidine 13623-98-8 | C4H7N3O2 129.117 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D2977 | Vigabatrin 60643-86-9 | C6H11NO2 129.157 g/mol |  |
| Vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabol...more Number of Targets: 2 |
| T3D0634 | Quinoline 91-22-5 | C9H7N 129.159 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 6 |
| T3D3522 | 1,1-Dimethylbiguanide 657-24-9 | C4H11N5 129.164 g/mol |  |
| Metformin's mechanisms of action differ from other classes of oral antihyperglycemic agents. Metformin decreases blood glucose levels by decreasing hepatic glucose pro...more Number of Targets: 4 |
| T3D0687 | Nickel chloride 7718-54-9 | Cl2Ni 129.599 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 69 |
| T3D0659 | Cobaltous chloride 7646-79-9 | Cl2Co 129.839 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 36 |
| T3D0715 | Lithium chromate 14307-35-8 | CrLi2O4 129.876 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D0243 | Sodium arsenite 7784-46-5 | AsNaO2 129.910 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D4776 | Fluorouracil 51-21-8 | C4H3FN2O2 130.077 g/mol |  |
| The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the dr...more Number of Targets: 5 |
| T3D4358 | Glutaconic acid 1724-02-3 | C5H6O4 130.099 g/mol |  |
| Accumulating trans-glutaconic (TG) acids has been proposed to be involved in the development of the striatal degeneration seen in children with glutaric acidemia type ...more Number of Targets: 1 |
| T3D4424 | 3-Methyl-2-oxovaleric acid 1460-34-0 | C6H10O3 130.142 g/mol |  |
| 3-Methyl-2-oxovaleric acid is produced from isoleucine by cytosolic branched chain aminotransferase 1, whereupon it is further degraded by branched chain keto acid deh...more Number of Targets: 0 |
| T3D4426 | Ketoleucine 816-66-0 | C6H10O3 130.142 g/mol |  |
| Ketoleucine is a metabolite that accumulates in Maple Syrup Urine Disease (MSUD) and shown to compromise brain energy metabolism by blocking the respiratory chain. Number of Targets: 0 |
| T3D4597 | Heptanoic acid 111-14-8 | C7H14O2 130.185 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4851 | Isopentyl acetate 123-92-2 | C7H14O2 130.185 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D0112 | n-Nitrosodi-n-propylamine 621-64-7 | C6H14N2O 130.188 g/mol |  |
| Reactive metabolites of n-nitrosodi-n-propylamine are believed to form adducts with DNA, resulting in carcinogenic effects. (L216) Number of Targets: 1 |
| T3D1676 | Methylene thiocyanate 6317-18-6 | C3H2N2S2 130.191 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 66 |
| T3D0132 | Iodine-131 10043-66-0 | I 130.906 g/mol |  |
| Iodide inhibits adenylate cyclase in thyroid gland follicle cells and decreases the TSH-induced rise in intracellular cAMP. This results in decreased iodination of thy...more Number of Targets: 11 |