Browsing Toxins
Displaying toxin 376 - 400 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3557 | Chlorine nitrate 14545-72-3 | ClNO3 97.458 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 9 |
| T3D0745 | Zinc sulfide 1314-98-3 | SZn 97.474 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D1211 | Copper(II) hydroxide 20427-59-2 | CuH2O2 97.561 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D0678 | Lithium cobalt oxide 12190-79-3 | CoLiO2 97.873 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D1721 | Ammonium bromide 12124-97-9 | BrH4N 97.942 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D4896 | Phosphoric acid 7664-38-2 | H3O4P 97.995 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D3770 | Moniliformin 71376-34-6 | C4H2O3 98.057 g/mol |  |
| Moniliformin reversibly inhibits the enzymes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase by competing for the binding site of pyruvate. This interfere...more Number of Targets: 7 |
| T3D5000 | Sulfuric acid 7664-93-9 | H2O4S 98.078 g/mol |  |
| Many strong acids cause tissue burns through the denaturation of proteins and partial hydrolysis of proteins. Most proteins denature at pH values of less than 3-4. T...more Number of Targets: 0 |
| T3D4189 | 2-Hexenal 505-57-7 | C6H10O 98.143 g/mol |  |
| Uremic toxins such as 2-Hexenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimula...more Number of Targets: 4 |
| T3D4894 | 4-Methyl-3-penten-2-one, 9CI 141-79-7 | C6H10O 98.143 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D0085 | 1,2-Dichloroethane 107-06-2 | C2H4Cl2 98.959 g/mol |  |
| 1,2-Dichloroethane is metabolized to 2-chloroacetaldehyde, S-(2-chloroethyl)glutathione by conjugation with glutathione, and to other putative reactive intermediates c...more Number of Targets: 39 |
| T3D0160 | 1,1-Dichloroethane 75-34-3 | C2H4Cl2 98.959 g/mol |  |
| The limited information available about 1,1-dichloroethane suggests that it may be nephrotoxic, fetotoxic, and possibly carcinogenic. 1,1-Dichloroethane has been obser...more Number of Targets: 40 |
| T3D1201 | Copper(I) chloride 7758-89-6 | ClCu 98.999 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D1666 | n-Butyl isocyanate 111-36-4 | C5H9NO 99.131 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D4946 | 1-Methyl-2-pyrrolidone 872-50-4 | C5H9NO 99.131 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D0778 | Allyl isothiocyanate 57-06-7 | C4H5NS 99.154 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 41 |
| T3D0769 | Trimethylsilyl cyanide 7677-24-9 | C4H9NSi 99.207 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |
| T3D0731 | Zinc hydroxide 20427-58-1 | H2O2Zn 99.424 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D0737 | Zinc peroxide 1314-22-3 | H2O2Zn 99.424 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 2 |
| T3D2413 | Sodium phosphide 12058-85-4 | Na3P 99.943 g/mol |  |
| Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to...more Number of Targets: 20 |
| T3D0065 | Chromium(VI) oxide 1333-82-0 | CrO3 99.994 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D3580 | Sodium fluoroacetate 62-74-8 | C2H2FNaO2 100.024 g/mol |  |
| Fluoroacetate is similar to acetate, which has a pivotal role in cellular metabolism. Fluoroacetate disrupts the citric acid cycle by combining with coenzyme A to form...more Number of Targets: 0 |
| T3D3216 | Ethyl acrylate 140-88-5 | C5H8O2 100.116 g/mol |  |
| Ethyl acrylate causes gastric lesions depending upon upon the rate of chemical delivery to stomach tissue as a result of interaction of the parent molecule or metaboli...more Number of Targets: 0 |
| T3D4844 | Glutaral 111-30-8 | C5H8O2 100.116 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D2453 | Gyromitrin 16568-02-8 | C4H8N2O 100.119 g/mol |  |
| The toxicity is caused by the conversion of the hydrazine (gyromitrin) to a hydrazine metabolite intermediate monomethylhydrazine. This occurs when gyromitrin begins t...more Number of Targets: 0 |