Browsing Toxins
Displaying toxin 351 - 375 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0303 | Methylarsine 593-52-2 | CH5As 91.972 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D3559 | Dinitrogen tetroxide 10544-72-6 | N2O4 92.011 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 9 |
| T3D4360 | Glycerol 56-81-5 | C3H8O3 92.094 g/mol |  |
| Not Available Number of Targets: 12 |
| T3D0759 | Calcium cyanide 592-01-8 | C2CaN2 92.113 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 42 |
| T3D0071 | Toluene 108-88-3 | C7H8 92.138 g/mol |  |
| Toluene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 39 |
| T3D4662 | Chloracetone 78-95-5 | C3H5ClO 92.524 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D0693 | Nickel hydroxide 12054-48-7 | H2NiO2 92.708 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 68 |
| T3D1146 | Manganese fluoride 7782-64-1 | F2Mn 92.935 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 5 |
| T3D0662 | Cobalt(II) hydroxide 21041-93-0 | CoH2O2 92.948 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D4984 | Aniline 62-53-3 | C6H7N 93.127 g/mol |  |
| Aniline induces lipid peroxidation and protein oxidation in the spleen and that oxidative stress plays a role in the splenic toxicity of aniline. The hematopoietic sys...more Number of Targets: 2 |
| T3D3570 | Methylammonium nitrate 22113-87-7 | CH6N2O3 94.070 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 9 |
| T3D0182 | Phenol 108-95-2 | C6H6O 94.111 g/mol |  |
| Phenol is irritating and corrosive at high concentrations. Phenol impairs the stratum corneum and produces coagulation necrosis by denaturing and precipitating protein...more Number of Targets: 13 |
| T3D1703 | Glutaronitrile 544-13-8 | C5H6N2 94.115 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 39 |
| T3D2553 | 4-Aminopyridine 504-24-5 | C5H6N2 94.115 g/mol |  |
| 4-Aminopyridine blocks potassium channels and thereby increases acetylcholine, and possibly noradrenaline, release at nerve terminals (A316). In MS, axons are progress...more Number of Targets: 17 |
| T3D1787 | Bromomethane 74-83-9 | CH3Br 94.939 g/mol |  |
| Organobromide compounds such as bromomethane are strong alkylating agents. Consequently they can readily modify free thiols (cysteines) and methionine residues of the...more Number of Targets: 3 |
| T3D1654 | Trifluoromethyl isocyanide 105879-13-8 | C2F3N 95.023 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D0749 | Dimethylzinc 544-97-8 | C2H6Zn 95.478 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D1198 | Copper(II) sulfide 1317-40-4 | CuS 95.611 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D3957 | Molybdenum 7439-98-7 | Mo 95.940 g/mol |  |
| High levels of molybdenum can interfere with the body's uptake of copper, producing copper deficiency. Molybdenum prevents plasma proteins from binding to copper, and ...more Number of Targets: 1 |
| T3D3562 | Hydroxylammonium nitrate 13465-08-2 | H4N2O4 96.043 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 9 |
| T3D3982 | 2,5-Dimethylfuran 625-86-5 | C6H8O 96.127 g/mol |  |
| 2,5-Dimethylfuran plays a role in the mechanism for the neurotoxicity of hexane in humans. Together with hexane-2,5-dione and 4,5-dihydroxy-2-hexanone, it is one of th...more Number of Targets: 0 |
| T3D0692 | Nickel fluoride 10028-18-9 | F2Ni 96.690 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 68 |
| T3D0660 | Cobalt(II) fluoride 10026-17-2 | CoF2 96.930 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D0079 | 1,1-Dichloroethene 75-35-4 | C2H2Cl2 96.943 g/mol |  |
| 1,1-Dichloroethene toxicity is caused by its reactive metabolites, which include epoxides, acyl chlorides, and halogenated aldehydes generated via oxidation by cytochr...more Number of Targets: 39 |
| T3D0173 | trans-1,2-Dichloroethene 156-60-5 | C2H2Cl2 96.943 g/mol |  |
| Trans-1,2-dichloroethene is a volatile, lipophilic molecule that easily moves through the respiratory and gastrointestinal systems. It has a high affinity for lipids a...more Number of Targets: 4 |