Browsing Toxins
Displaying toxin 3651 - 3675 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3614 | Microcystin-LW 157622-02-1 | C54H72N8O12 1025.196 g/mol |  |
| The site of action of microcystins is the hepatocyte, the commonest cell type in the liver. They act by disrupting the cytoskeleton, the adaptable protein framework th...more Number of Targets: 23 |
| T3D3609 | Microcystin-RR 111755-37-4 | C49H75N13O12 1038.200 g/mol |  |
| The site of action of microcystins is the hepatocyte, the commonest cell type in the liver. They act by disrupting the cytoskeleton, the adaptable protein framework th...more Number of Targets: 23 |
| T3D2566 | Heparin 9005-49-6 | C26H41NO34S4 1039.850 g/mol |  |
| Heparin-induced thrombocytopenia (HIT) is caused by the formation of abnormal antibodies that activate platelets. Heparin occurs naturally in the human body, but the d...more Number of Targets: 14 |
| T3D3608 | Microcystin-YR 101064-48-6 | C52H72N10O13 1045.187 g/mol |  |
| The site of action of microcystins is the hepatocyte, the commonest cell type in the liver. They act by disrupting the cytoskeleton, the adaptable protein framework th...more Number of Targets: 23 |
| T3D1286 | Hexakis(2-methyl-2-phenylpropyl)distannoxane 13356-08-6 | C60H80OSn2 1054.700 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |
| T3D2466 | Ciguatoxin 4B 123676-76-6 | C60H84O16 1061.299 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2464 | Ciguatoxin 2 142185-85-1 | C60H86O18 1095.314 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2465 | 54-Deoxyciguatoxin 139341-09-6 | C60H86O18 1095.314 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D2463 | Ciguatoxin 1 11050-21-8 | C60H86O19 1111.313 g/mol |  |
| Ciguatoxin lowers the threshold for opening voltage-gated sodium channels in synapses of the nervous system. The effect of opening a sodium channel will cause depolari...more Number of Targets: 14 |
| T3D3067 | Vapreotide 103222-11-3 | C57H70N12O9S2 1131.371 g/mol |  |
| The exact mechanism of action is unknown, although one study has provided in vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect in the analgesi...more Number of Targets: 3 |
| T3D2763 | Anidulafungin 166663-25-8 | C58H73N7O17 1140.237 g/mol |  |
| Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. ...more Number of Targets: 6 |
| T3D1579 | Tetrakis(triphenylphosphine)palladium(0) 14221-01-3 | C72H64P4Pd 1159.590 g/mol |  |
| Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more Number of Targets: 6 |
| T3D3498 | Cyclosporin 59865-13-3 | C62H111N11O12 1202.611 g/mol |  |
| Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also...more Number of Targets: 7 |
| T3D3529 | Polymyxin B Sulfate 1405-20-5 | C56H98N16O13 1203.477 g/mol |  |
| Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysacchar...more Number of Targets: 0 |
| T3D4915 | gamma-Cyclodextrin 17465-86-0 | C48H80O40 1297.125 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1097 | Barium cadmium stearate 1191-79-3 | C72H148BaCaO8 1319.346 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 40 |
| T3D2855 | Nafarelin 76932-56-4 | C66H83N17O13 1322.471 g/mol |  |
| Like GnRH, initial or intermittent administration of nafarelin stimulates release of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) ...more Number of Targets: 2 |
| T3D0679 | Methylcobalamin 13422-55-4 | C63H91CoN13O14P 1344.382 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D0677 | Hydroxocobalamin 13422-51-0 | C62H89CoN13O15P 1346.355 g/mol |  |
| Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of th...more Number of Targets: 45 |
| T3D0673 | Cyanocobalamin 68-19-9 | C63H88CoN14O14P 1355.365 g/mol |  |
| Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This e...more Number of Targets: 46 |
| T3D2738 | Bleomycin 11056-06-7 | C55H84N17O21S3 1415.551 g/mol |  |
| It has been suggested that bleomycin induces sensitivity to oxygen toxicity and recent studies support the role of the proinflammatory cytokines IL-18 and IL-1beta in ...more Number of Targets: 4 |
| T3D3543 | Vancomycin 1404-90-6 | C66H75Cl2N9O24 1449.254 g/mol |  |
| The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic a...more Number of Targets: 1 |
| T3D0672 | Adenosylcobalamin 13870-90-1 | C72H100CoN18O17P 1579.582 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D1184 | Stryker's reagent 33636-93-0 | C108H96Cu6P6 1961.036 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D2487 | Apamin (Apis mellifera) 24345-16-2 | Not Available 5223.305 g/mol |  |
| Apamin binds to the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord and inhibits them, likely by acting as a pore blocker. Inhi...more Number of Targets: 3 |