Browsing Toxins
Displaying toxin 3301 - 3325 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3679 | Cytochalasin E 36011-19-5 | C27H33NO7 483.553 g/mol |  |
| Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monome...more Number of Targets: 6 |
| T3D2188 | 1,2,7,8-Tetrabromodibenzofuran 84761-80-8 | C12H4Br4O 483.776 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2242 | 2,3,7,8-Tetrabromodibenzofuran 67733-57-7 | C12H4Br4O 483.776 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D3722 | Verrucarin J 4643-58-7 | C27H32O8 484.538 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D4234 | Lipopolysaccharide Not Available | C21H44NO9P 485.549 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D2039 | Tetrabromodiphenyl ethers 40088-47-9 | C12H6Br4O 485.791 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D1860 | Antimony tetramer 12597-17-0 | Sb4 487.040 g/mol |  |
| The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes ...more Number of Targets: 20 |
| T3D0367 | Cadmium arsenide 12006-15-4 | As2Cd3 487.076 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 62 |
| T3D3651 | Diisoundecyl phthalate 85507-79-5 | C31H52O4 488.742 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D2626 | alpha-Agatoxin 128549-96-2 | C26H47N7O2 489.697 g/mol |  |
| alpha-Agatoxins block the glutamate-activated receptor channels in the neuronal postsynaptic terminals of insects and mammals, preventing excitory junction potential f...more Number of Targets: 11 |
| T3D0138 | Chlordecone 143-50-0 | C10Cl10O 490.636 g/mol |  |
| It is believed that the α-noradrenergic and serotonergic transmitter systems in the central nervous system are the primary neurotransmitter systems affected by chlorde...more Number of Targets: 55 |
| T3D4278 | Deoxyadenosine triphosphate 1927-31-7 | C10H16N5O12P3 491.182 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D0276 | Arsenic trisulfide 1303-33-9 | As4S6 492.076 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D2524 | Slotoxin 144026-79-9 | Not Available 4091.850 g/mol |  |
| Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits and irreversibly blocks the high conductance calci...more Number of Targets: 3 |
| T3D4852 | Carmine red 1260-17-9 | C22H20O13 492.386 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D3941 | Triflusulfuron-methyl 126535-15-7 | C17H19F3N6O6S 492.430 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D4521 | Novaluron 116714-46-6 | C17H9ClF8N2O4 492.705 g/mol |  |
| Not Available Number of Targets: 6 |
| T3D4066 | Ryanodine 15662-33-6 | C25H35NO9 493.547 g/mol |  |
| Ryanodine has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells....more Number of Targets: 1 |
| T3D3680 | Cytochalasin H 53760-19-3 | C30H39NO5 493.634 g/mol |  |
| Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monome...more Number of Targets: 6 |
| T3D1257 | Tri-n-octyltin chloride 2587-76-0 | C24H51ClSn 493.820 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |
| T3D1742 | Niobium(V) bromide 13748-45-0 | Br5H4Nb 496.458 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D0358 | Mercury(I) sulfate 7783-36-0 | Hg2O4S 497.240 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D0598 | Decachlorobiphenyl 2051-24-3 | C12Cl10 498.658 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D3899 | Perfluorooctanesulfonic acid 1763-23-1 | C8HF17O3S 500.130 g/mol |  |
| Not Available Number of Targets: 19 |
| T3D3721 | Verrucarin B 2290-11-1 | C27H32O9 500.538 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |