Browsing Toxins
Displaying toxin 2851 - 2875 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2163 | 1,2,3,7,8,9-Hexachlorodibenzofuran 72918-21-9 | C12H2Cl6O 374.862 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2171 | 1,2,4,6,7,8-Hexachlorodibenzofuran 67562-40-7 | C12H2Cl6O 374.862 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2172 | 1,2,4,6,7,9-Hexachlorodibenzofuran 75627-02-0 | C12H2Cl6O 374.862 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2174 | 1,2,4,6,8,9-Hexachlorodibenzofuran 69698-59-5 | C12H2Cl6O 374.862 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2192 | 1,3,4,6,7,8-Hexachlorodibenzofuran 71998-75-9 | C12H2Cl6O 374.862 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2193 | 1,3,4,6,7,9-Hexachlorodibenzofuran 92341-05-4 | C12H2Cl6O 374.862 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2229 | 2,3,4,6,7,8-Hexachlorodibenzofuran 60851-34-5 | C12H2Cl6O 374.862 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2823 | Hydroxyzine 68-88-2 | C21H27ClN2O2 374.904 g/mol |  |
| Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. T...more Number of Targets: 4 |
| T3D1287 | Tributyltin methacrylate 2155-70-6 | C16H32O2Sn 375.130 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 49 |
| T3D1119 | Barium permanganate 7787-36-2 | BaMn2O8 375.198 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 26 |
| T3D2968 | Gatifloxacin 112811-59-3 | C19H22FN3O4 375.394 g/mol |  |
| The bactericidal action of Gatifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA...more Number of Targets: 3 |
| T3D1033 | Cyphenothrin 39515-40-7 | C24H25NO3 375.460 g/mol |  |
| Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to th...more Number of Targets: 19 |
| T3D2926 | Tiagabine 115103-54-3 | C20H25NO2S2 375.548 g/mol |  |
| Though the exact mechanism by which Tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. Number of Targets: 4 |
| T3D1609 | Silver molybdate 13765-74-4 | Ag2MoO4 375.670 g/mol |  |
| Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disr...more Number of Targets: 17 |
| T3D2576 | Haloperidol 52-86-8 | C21H23ClFNO2 375.864 g/mol |  |
| The precise mechanism whereby the therapeutic effects of haloperidol are produced is not known, but the drug appears to depress the CNS at the subcortical level of the...more Number of Targets: 26 |
| T3D0708 | Pyridinium dichromate 20039-37-6 | C10H12Cr2N2O7 376.204 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D1832 | Gallium(III) selenide 12024-24-7 | Ga2Se3 376.330 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D4817 | Riboflavin 83-88-5 | C17H20N4O6 376.364 g/mol |  |
| Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and f...more Number of Targets: 4 |
| T3D4963 | Lithocholic acid 434-13-9 | C24H40O3 376.573 g/mol |  |
| Not Available Number of Targets: 11 |
| T3D3903 | Prochloraz 67747-09-5 | C15H16Cl3N3O2 376.665 g/mol |  |
| Prochloraz acts in vitro as a an aromatase inhibitor, aryl hydrocarbon receptor agonist, androgen receptor antagonist, and estrogen receptor antagonist. (A15203) Number of Targets: 36 |
| T3D2326 | 6-Methyl-8-iodo-1,3-dichlordibenzofuran 132194-83-3 | C13H7Cl2IO 377.005 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D1346 | Cadmium mercury sulfide 1345-09-1 | CdHgS2 377.130 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 69 |
| T3D4565 | Haloxazolam 59128-97-1 | C17H14BrFN2O2 377.208 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 18 |
| T3D1295 | Arsenamide 531-72-6 | C11H12AsNO5S2 377.268 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0616 | Methiochlor 19679-38-0 | C16H15Cl3S2 377.779 g/mol |  |
| At least four mechanisms, possibly all functioning simultaneously. Methiochlor reduces potassium transport across the membrane. Methiochlor alters the porous channels ...more Number of Targets: 42 |