Browsing Toxins
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1958 | 2,2',3,3',5,5'-Hexabromobiphenyl 55066-76-7 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1951 | 2,2',4,4',5,6'-Hexabromobiphenyl 36402-15-0 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1938 | 2,3,3',4,5,5'-Hexabromobiphenyl 120991-48-2 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1937 | 2,2',3,4,5,5'-Hexabromobiphenyl 120991-47-1 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1926 | 2,2',3,5,5',6-Hexabromobiphenyl 119264-53-8 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1925 | 2,2',3,4,5',6-Hexabromobiphenyl 119264-52-7 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1924 | 2,2',3,3',5,6'-Hexabromobiphenyl 119264-51-6 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1923 | 2,2',3,3',4,6'-Hexabromobiphenyl 119264-50-5 | C12H4Br6 627.584 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D1278 | Tin(IV) iodide 7790-47-8 | I4Sn 626.330 g/mol |  |
| Inorganic and organic tin compounds are weak inhibitors of alcohol dehydrogenase. (A183) Number of Targets: 7 |
| T3D0664 | Cobalt(II) mesoporphyrin 21158-51-0 | C34H36CoN4O4 623.607 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D4983 | Tiratricol 51-24-1 | C14H9I3O4 621.932 g/mol |  |
| Tiratricol is a naturally occurring metabolite of T4 (thyroxine) and a structural analog of T3 (triiodothyronine). Low concentrations of tiratricol are found in plasma...more Number of Targets: 1 |
| T3D1561 | Tritetradecylaluminum 1529-58-4 | C42H87Al 619.122 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D1188 | Chlorophyllin 11006-34-1 | C34H34MgN4O6 618.962 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D2951 | Neomycin 1404-04-2 | C23H46N6O13 614.644 g/mol |  |
| Aminoglycosides like neomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a sing...more Number of Targets: 3 |
| T3D1555 | Aluminum distearate 300-92-5 | C36H72AlO5 611.935 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D3097 | Tubocurarine 6989-98-6 | C37H41N2O6 609.731 g/mol |  |
| Tubocurarine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholines...more Number of Targets: 21 |
| T3D3688 | Ergocristine 511-08-0 | C35H39N5O5 609.715 g/mol |  |
| Ergoline alkaloids tend to act as a group, producing complex and variable effects of partial agonism or antagonism at adrenergic, dopaminergic, and serotonergic recept...more Number of Targets: 7 |
| T3D2713 | Reserpine 50-55-5 | C33H40N2O9 608.679 g/mol |  |
| Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the p...more Number of Targets: 18 |
| T3D4757 | Fulvestrant 129453-61-8 | C32H47F5O3S 606.771 g/mol |  |
| Fulvestrant competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. Fi...more Number of Targets: 7 |
| T3D3764 | Janthitrem E 90986-50-8 | C37H49NO6 603.788 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 22 |
| T3D3952 | Lymecycline 992-21-2 | C29H38N4O10 602.633 g/mol |  |
| Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mitochondrial protein synthesis. As a result tetracyclines are cytotoxic ...more Number of Targets: 1 |
| T3D3734 | Penitrem C 37318-84-6 | C37H44ClNO4 602.203 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 27 |
| T3D3077 | Delphinine 561-07-9 | C33H45NO9 599.712 g/mol |  |
| Delphinine acts as an allosteric modulator of voltage-gated sodium channels. (L1234) Number of Targets: 14 |
| T3D3754 | Emestrin 97816-62-1 | C27H22N2O10S2 598.601 g/mol |  |
| Emestrin causes degeneration of the mitochondria in both cardiac muscle cells and hepatocytes, leading to necrosis. It is also known to act as an antagonist at the che...more Number of Targets: 2 |
| T3D4068 | C-Curarine 7168-64-1 | C40H44N4O 596.803 g/mol |  |
| It has been prpoposed that surarine speeds up destruction of chemical transmitter, and raises the threshold point at which excess of the transmitter is able to exert i...more Number of Targets: 0 |