Browsing Toxins
Displaying toxin 776 - 800 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3840 | Fluazifop-butyl 69806-50-4 | C19H20F3NO4 383.362 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D2796 | Loratadine 79794-75-5 | C22H23ClN2O2 382.883 g/mol |  |
| Loratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which sub...more Number of Targets: 3 |
| T3D1347 | Mercuric potassium cyanide 591-89-9 | C4HgK2N4 382.860 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 91 |
| T3D0974 | Furathiocarb 65907-30-4 | C18H26N2O5S 382.474 g/mol |  |
| Furathiocarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sit...more Number of Targets: 2 |
| T3D4572 | Tofisopam 22345-47-7 | C22H26N2O4 382.453 g/mol |  |
| Tofisopam does not bind to the benzodiazepine binding site of the gamma-aminobutyric acid receptor. One study (Rundfeldt C. et al.) has shown that tofisopam acts as an...more Number of Targets: 22 |
| T3D3708 | Neosolaniol 36519-25-2 | C19H26O8 382.405 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D4558 | Azelastine 58581-89-8 | C22H24ClN3O 381.898 g/mol |  |
| Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators inv...more Number of Targets: 7 |
| T3D0702 | Cesium chromate 56320-90-2 | CrCs2O4 381.805 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D2992 | Econazole 27220-47-9 | C18H15Cl3N2O 381.684 g/mol |  |
| Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fung...more Number of Targets: 4 |
| T3D0930 | Benthiavalicarb-isopropyl 177406-68-7 | C18H24FN3O3S 381.465 g/mol |  |
| Benthiavalicarb-isopropyl is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of t...more Number of Targets: 2 |
| T3D4771 | Celecoxib 169590-42-5 | C17H14F3N3O2S 381.372 g/mol |  |
| The mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (C...more Number of Targets: 7 |
| T3D3883 | Metsulfuron-methyl 74223-64-6 | C14H15N5O6S 381.364 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D0069 | Endrin aldehyde 7421-93-4 | C12H8Cl6O 380.909 g/mol |  |
| Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch...more Number of Targets: 38 |
| T3D0063 | Endrin ketone 53494-70-5 | C12H8Cl6O 380.909 g/mol |  |
| Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch...more Number of Targets: 38 |
| T3D0041 | Endrin 72-20-8 | C12H8Cl6O 380.909 g/mol |  |
| Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch...more Number of Targets: 42 |
| T3D0017 | Dieldrin 60-57-1 | C12H8Cl6O 380.909 g/mol |  |
| Dieldrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ...more Number of Targets: 46 |
| T3D0326 | Lead fluoroborate 13814-96-5 | B2F8Pb 380.800 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D0235 | (±)-Naled 300-76-5 | C4H7Br2Cl2O4P 380.784 g/mol |  |
| (±)-Naled is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 11 |
| T3D1223 | Copper(II) phosphate 7798-23-4 | Cu3O8P2 380.581 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D1222 | Copper orthophosphate 10103-48-7 | Cu3O8P2 380.581 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D0945 | Carbosulfan 55285-14-8 | C20H32N2O3S 380.545 g/mol |  |
| Carbosulfan is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active site...more Number of Targets: 2 |
| T3D4824 | CP-122721 145742-28-5 | C20H23F3N2O2 380.404 g/mol |  |
| CP-122721 is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 13 |
| T3D1167 | Uranium tetrachloride 10026-10-5 | Cl4U 379.841 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D1729 | Cerium(III) bromide 14457-87-5 | Br3Ce 379.828 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D2910 | Donepezil 120014-06-4 | C24H29NO3 379.492 g/mol |  |
| Donepezil is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 4 |