Browsing Toxins
Displaying toxin 751 - 775 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2956 | Tioconazole 65899-73-2 | C16H13Cl3N2OS 387.711 g/mol |  |
| Tioconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this wa...more Number of Targets: 2 |
| T3D4937 | 4-Hydroxytamoxifen 68047-06-3 | C26H29NO2 387.514 g/mol |  |
| Not Available Number of Targets: 22 |
| T3D3537 | Terazosin 70024-40-7 | C19H25N5O4 387.433 g/mol |  |
| Terazosin selectively and competitively inhibits vascular postsynaptic alpha(1)-adrenergic receptors, resulting in peripheral vasodilation and a reduction of vascular ...more Number of Targets: 6 |
| T3D3924 | Sulfentrazone 122836-35-5 | C11H10Cl2F2N4O3S 387.190 g/mol |  |
| Not Available Number of Targets: 11 |
| T3D3055 | Quazepam 36735-22-5 | C17H11ClF4N2S 386.794 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodia...more Number of Targets: 18 |
| T3D1301 | Arsenic triselenide 1303-36-2 | As2Se3 386.720 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D4314 | Cholesterol 57-88-5 | C27H46O 386.654 g/mol |  |
| Cholesterol is essential for life. However, chronically high levels (from diet or from genetic predisposition or from diseases such as hyperlipidemia) of cholesterol a...more Number of Targets: 12 |
| T3D2933 | Mesoridazine 5588-33-0 | C21H26N2OS2 386.574 g/mol |  |
| Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is re...more Number of Targets: 14 |
| T3D2865 | Sufentanil 56030-54-7 | C22H30N2O2S 386.551 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 4 |
| T3D4730 | Medroxyprogesterone Acetate 71-58-9 | C24H34O4 386.524 g/mol |  |
| Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Onc...more Number of Targets: 2 |
| T3D0738 | Zinc phosphate 7779-90-0 | O8P2Zn3 386.170 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D2807 | Buspirone 36505-84-7 | C21H31N5O2 385.503 g/mol |  |
| Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firi...more Number of Targets: 10 |
| T3D2378 | Taziprinone 79253-92-2 | C22H31N3O3 385.500 g/mol |  |
| Dibenzofurans bind the aryl hydrocarbon receptor, which increases its ability to activate transcription in the XRE promoter region. This alters the expression of a num...more Number of Targets: 4 |
| T3D1253 | Triphenyltin chloride 639-58-7 | C18H15ClSn 385.470 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |
| T3D1284 | Tricyclohexyltin hydroxide 13121-70-5 | C18H34OSn 385.170 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |
| T3D1471 | Zinc dithiophosphate 19210-06-1 | O4P2S4Zn2 385.023 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D2306 | 4-Bromo-2,3,7,8-tetrachlorodibenzofuran 115656-08-1 | C12H3BrCl4O 384.868 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2703 | Cholecalciferol 67-97-0 | C27H44O 384.638 g/mol |  |
| The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mito...more Number of Targets: 4 |
| T3D0096 | Ethion 563-12-2 | C9H22O4P2S4 384.476 g/mol |  |
| Ethion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase...more Number of Targets: 10 |
| T3D0842 | 6,7-Dihydroxybergamottin 145414-76-2 | C23H28O5 384.465 g/mol |  |
| The mechanism of action many furocoumarins is based on their ability to form photoadducts with DNA and other cellular components such as RNA, proteins, and several pro...more Number of Targets: 3 |
| T3D4455 | S-Adenosylhomocysteine 979-92-0 | C14H20N6O5S 384.411 g/mol |  |
| Not Available Number of Targets: 17 |
| T3D2474 | Naftidrofuryl 31329-57-4 | C24H33NO3 383.524 g/mol |  |
| Naftidrofuryl blocks the type 2 serotonin (5-HT2) receptors and thereby inhibits the effects of serotonin-induced vasoconstriction
or platelet aggregation. It is also ...more Number of Targets: 3 |
| T3D4957 | (E)-N-[2-[[5-(Dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-1-(4-methylpiperazin-1-yl)-2-nitroethenamine 102787-23-5 | C17H29N5O3S 383.509 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 0 |
| T3D2555 | Quetiapine 111974-69-7 | C21H25N3O2S 383.507 g/mol |  |
| The mechanism of action of quetiapine, as with other drugs used to treat schizophrenia, is unknown. However, it is thought that the drug's therapeutic activity in schi...more Number of Targets: 30 |
| T3D3841 | Fluazifop-P-butyl 79241-46-6 | C19H20F3NO4 383.362 g/mol |  |
| Not Available Number of Targets: 6 |