Browsing Toxins
Displaying toxin 726 - 750 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2111 | 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin 39227-28-6 | C12H2Cl6O2 390.861 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept...more Number of Targets: 3 |
| T3D2110 | 1,2,3,4,6,7-Hexachlorodibenzo-p-dioxin 58200-66-1 | C12H2Cl6O2 390.861 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept...more Number of Targets: 3 |
| T3D2109 | 1,2,4,6,7,9-Hexachlorodibenzo-p-dioxin 39227-62-8 | C12H2Cl6O2 390.861 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah recepto...more Number of Targets: 4 |
| T3D2108 | 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin 19408-74-3 | C12H2Cl6O2 390.861 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept...more Number of Targets: 3 |
| T3D2107 | 1,2,3,6,7,9-Hexachlorodibenzo-p-dioxin 64461-98-9 | C12H2Cl6O2 390.861 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept...more Number of Targets: 3 |
| T3D2106 | 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 57653-85-7 | C12H2Cl6O2 390.861 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept...more Number of Targets: 3 |
| T3D3649 | Diisooctyl phthalate 27554-26-3 | C24H38O4 390.556 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D3641 | Di(n-octyl) phthalate 117-84-0 | C24H38O4 390.556 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 1 |
| T3D0076 | Di(2-ethylhexyl)phthalate 117-81-7 | C24H38O4 390.556 g/mol |  |
| Monoethylhexylphthalate (MEHP), one of the major metabolites of DEHP, induces peroxisome proliferation by activating peroxisome proliferator activated receptors. This ...more Number of Targets: 17 |
| T3D1177 | Uranyl acetate 541-09-3 | C4H8O6U 390.132 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D1635 | Vanadium(III) sulfate 13701-70-7 | O12S3V2 390.071 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D1140 | Dimanganese decacarbonyl 10170-69-1 | C10Mn2O10 389.977 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 5 |
| T3D1511 | Aluminium molybdate 15123-80-5 | Al2Mo2O9 389.840 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D3662 | Roquefortine 58735-64-1 | C22H23N5O2 389.450 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 23 |
| T3D1649 | Fluorescein isothiocyanate 27072-45-3 | C21H11NO5S 389.381 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D0046 | Heptachlor epoxide 1024-57-3 | C10H5Cl7O 389.317 g/mol |  |
| Heptachlor epoxide is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overs...more Number of Targets: 41 |
| T3D3066 | Bepotastine 125602-71-3 | C21H25ClN2O3 388.888 g/mol |  |
| Because of a type 1 hypersensitivity reaction cascade that is triggered by antigen exposure, allergic conjunctivitis occurs. Allergen exposure is followed by conjuncti...more Number of Targets: 1 |
| T3D2756 | Cetirizine 83881-51-0 | C21H25ClN2O3 388.888 g/mol |  |
| Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. Th...more Number of Targets: 5 |
| T3D4552 | Eszopiclone 138729-47-2 | C17H17ClN6O3 388.808 g/mol |  |
| The mechanism of action of Eszopiclone is not completely understood. It is thought that Eszopiclone acts on the benzodiazepine receptors as an agonist and interacts wi...more Number of Targets: 8 |
| T3D3016 | Zopiclone 43200-80-2 | C17H17ClN6O3 388.808 g/mol |  |
| Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Both zopic...more Number of Targets: 5 |
| T3D3625 | Imidazolidinyl urea 39236-46-9 | C11H16N8O8 388.294 g/mol |  |
| Imidazolidinyl urea is a formaldehyde releaser. It is likely that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, ...more Number of Targets: 2 |
| T3D1230 | Copper naphthenate 1338-02-9 | C19H32CuO4 388.001 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D2860 | Flurazepam 17617-23-1 | C21H23ClFN3O 387.878 g/mol |  |
| Benzodiazepines bind nonspecifically to bezodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity,...more Number of Targets: 21 |
| T3D4495 | Dimethomorph 110488-70-5 | C21H22ClNO4 387.857 g/mol |  |
| Not Available Number of Targets: 20 |
| T3D3914 | Pyraclostrobin 175013-18-0 | C19H18ClN3O4 387.817 g/mol |  |
| Not Available Number of Targets: 48 |