Browsing Toxins
Displaying toxin 651 - 675 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0663 | Cobalt(II) naphthenate 61789-51-3 | C22H14CoO4 401.277 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D2694 | Calcidiol 19356-17-3 | C27H44O2 400.637 g/mol |  |
| Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitriol, the active form of vitamin D3. Calcitriol binds to intracellular re...more Number of Targets: 2 |
| T3D2536 | Marinobufagenin 470-42-8 | C24H32O5 400.508 g/mol |  |
| Marinobufagin blocks the sodium/potassium pump in heart tissue. (L1084, L1085) Number of Targets: 0 |
| T3D0916 | Alanycarb 83130-01-2 | C17H25N3O4S2 399.528 g/mol |  |
| Alanycarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites ...more Number of Targets: 2 |
| T3D4456 | S-Adenosylmethionine 29908-03-0 | C15H23N6O5S 399.445 g/mol |  |
| S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a c...more Number of Targets: 10 |
| T3D4020 | Colchicine 64-86-8 | C22H25NO6 399.437 g/mol |  |
| Colchicine inhibits microtubule assembly in various cells, including leukocytes, probably by binding to and interfering with polymerization of the microtubule subunit ...more Number of Targets: 10 |
| T3D1371 | Cadmium 3-ethylhexanoate 2420-98-6 | C16H30CdO4 398.818 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 19 |
| T3D2974 | Dihydrotachysterol 67-96-9 | C28H46O 398.664 g/mol |  |
| Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptio...more Number of Targets: 1 |
| T3D1761 | Terbium(III) bromide 14456-47-4 | Br3Tb 398.637 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D0631 | Ovalene 190-26-1 | C32H14 398.454 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D2892 | Sulfasalazine 599-79-1 | C18H14N4O5S 398.393 g/mol |  |
| The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the a...more Number of Targets: 18 |
| T3D0241 | Calcium arsenate 7778-44-1 | As2Ca3O8 398.072 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D3797 | Bensulide 741-58-2 | C14H24NO4PS3 397.513 g/mol |  |
| Bensulide is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 31 |
| T3D1264 | Niobium tin 12035-04-0 | Nb3Sn 397.430 g/mol |  |
| Inorganic and organic tin compounds are weak inhibitors of alcohol dehydrogenase. (A183) Number of Targets: 7 |
| T3D1593 | Potassium hexachloro-palladate(IV) 10025-98-6 | Cl6K2Pd 397.330 g/mol |  |
| Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, an...more Number of Targets: 6 |
| T3D4286 | Hexacosanoic acid 506-46-7 | C26H52O2 396.690 g/mol |  |
| Adrenoleukodystrophy (ALD) is caused by mutations in ABCD1, a gene located on the X chromosome that codes for ALD, a peroxisomal membrane transporter protein. The exac...more Number of Targets: 0 |
| T3D2697 | Ergocalciferol 50-14-6 | C28H44O 396.648 g/mol |  |
| Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. Vitamin D2 must be transformed (hydroxylated) into one of two active form...more Number of Targets: 4 |
| T3D3704 | Diacetylnivalenol 14287-82-2 | C19H24O9 396.389 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D3933 | Thiazopyr 117718-60-2 | C16H17F5N2O2S 396.375 g/mol |  |
| Not Available Number of Targets: 12 |
| T3D1891 | Trimethyloxonium hexachlorantimonate 54075-76-2 | C3H9Cl6OSb 395.580 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D3937 | Tribenuron-methyl 101200-48-0 | C15H17N5O6S 395.390 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D4039 | Gonyautoxin II 60508-89-6 | C10H17N7O8S 395.349 g/mol |  |
| The gonyautoxin toxicity is caused by the reversibly binding to its receptor site on the voltage-gated sodium channel on excitable cells, thus blocking the influx of N...more Number of Targets: 0 |
| T3D0582 | 2,3,3',4',5,5',6-Heptachlorobiphenyl 69782-91-8 | C12H3Cl7 395.323 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D0581 | 2,3,3',4,5,5',6-Heptachlorobiphenyl 74472-51-8 | C12H3Cl7 395.323 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D0580 | 2,3,3',4,4',5',6-Heptachlorobiphenyl 74472-50-7 | C12H3Cl7 395.323 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |