Browsing Toxins
Displaying toxin 626 - 650 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2905 | Trifluoperazine 117-89-5 | C21H24F3N3S 407.496 g/mol |  |
| Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is bel...more Number of Targets: 18 |
| T3D0067 | beta Endosulfan 33213-65-9 | C9H6Cl6O3S 406.925 g/mol |  |
| Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake o...more Number of Targets: 49 |
| T3D2038 | Tribromobiphenyl Ether 49690-94-0 | C12H7Br3O 406.895 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D0704 | Iron(III) chromate 10294-52-7 | Cr3FeH3O12 406.850 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D3895 | Oxasulfuron 144651-06-9 | C17H18N4O6S 406.413 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D0638 | Basic beryllium acetate 19049-40-2 | C12H18Be4O13 406.312 g/mol |  |
| Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a m...more Number of Targets: 3 |
| T3D3828 | Difenoconazole 119446-68-3 | C19H17Cl2N3O3 406.263 g/mol |  |
| Not Available Number of Targets: 30 |
| T3D3825 | Diclosulam 145701-21-9 | C13H10Cl2FN5O3S 406.220 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D1814 | Bromopentacarbonylrhenium(I) 14220-21-4 | C5BrO5Re 406.162 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D1335 | Lead perchlorate 13637-76-8 | Cl2O8Pb 406.100 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D0674 | Dicobalt edetate 36499-65-7 | C10H12Co2N2O8 406.077 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D4976 | Clomifene 911-45-5 | C26H28ClNO 405.960 g/mol |  |
| Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. Clomifene appears to stumulate the release o...more Number of Targets: 2 |
| T3D1864 | Chlorohydroxytriphenylantimony 36368-97-5 | C18H16ClOSb 405.530 g/mol |  |
| The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes ...more Number of Targets: 20 |
| T3D2384 | Tribromodibenzofuran 103456-41-3 | C12H5Br3O 404.879 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D1364 | Thiomersal 54-64-8 | C9H9HgNaO2S 404.810 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 53 |
| T3D4787 | Lovastatin 75330-75-5 | C24H36O5 404.540 g/mol |  |
| Lovastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Lovastatin is a prodrug that is activated in vivo via hy...more Number of Targets: 10 |
| T3D2913 | Perphenazine 58-39-9 | C21H26ClN3OS 403.969 g/mol |  |
| Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamin...more Number of Targets: 13 |
| T3D3851 | Fluthiacet-methyl 117337-19-6 | C15H15ClFN3O3S2 403.879 g/mol |  |
| Not Available Number of Targets: 10 |
| T3D3605 | Ochratoxin A 303-47-9 | C20H18ClNO6 403.813 g/mol |  |
| Ochratoxin A has been shown to be weakly mutagenic, possibly by induction of oxidative DNA damage. The nephrotoxin ochratoxin A (OTA) causes a reduction of glomerular ...more Number of Targets: 5 |
| T3D3795 | Azoxystrobin 131860-33-8 | C22H17N3O5 403.388 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 17 |
| T3D3737 | Citreoviridin A 25425-12-1 | C23H30O6 402.481 g/mol |  |
| Citreoviridin inhibits both membrane-bound and soluble mitochondrial ATPases. In particular, it inhibits synaptosomal Na+/K+-ATPase, altering synaptic transmission, an...more Number of Targets: 15 |
| T3D4871 | Acetyl tributyl citrate 77-90-7 | C20H34O8 402.479 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D3936 | Triasulfuron 82097-50-5 | C14H16ClN5O5S 401.825 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D1866 | Diantimony diselenide 193095-46-4 | Sb2Se2 401.440 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D4499 | Dithiopyr 97886-45-8 | C15H16F5NO2S2 401.415 g/mol |  |
| Not Available Number of Targets: 18 |