Browsing Toxins
Displaying toxin 551 - 575 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3673 | HT-2 Toxin 26934-87-2 | C22H32O8 424.485 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D1895 | Triphenylantimony dichloride 594-31-0 | C18H15Cl2Sb 423.980 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D3846 | Flumiclorac-pentyl 87546-18-7 | C21H23ClFNO5 423.862 g/mol |  |
| Not Available Number of Targets: 12 |
| T3D0055 | Endosulfan sulfate 1031-07-8 | C9H6Cl6O4S 422.925 g/mol |  |
| Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced ...more Number of Targets: 42 |
| T3D1843 | Bifenthrin 82657-04-3 | C23H22ClF3O2 422.868 g/mol |  |
| Pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase i...more Number of Targets: 33 |
| T3D4510 | Flumetralin 62924-70-3 | C16H12ClF4N3O4 421.731 g/mol |  |
| Not Available Number of Targets: 22 |
| T3D0320 | Lead arsenite 10031-13-7 | As2O4Pb 421.000 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 73 |
| T3D1890 | Trimethylantimony diiodide 13077-53-7 | C3H9I2Sb 420.670 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D3911 | Propoxycarbazone-sodium 181274-15-7 | C15H17N4NaO7S 420.373 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D1037 | Fenvalerate 51630-58-1 | C25H22ClNO3 419.900 g/mol |  |
| Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to th...more Number of Targets: 25 |
| T3D1036 | Esfenvalerate 66230-04-4 | C25H22ClNO3 419.900 g/mol |  |
| Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to th...more Number of Targets: 35 |
| T3D3912 | Prosulfuron 94125-34-5 | C15H16F3N5O4S 419.379 g/mol |  |
| Not Available Number of Targets: 12 |
| T3D0718 | Potassium zinc chromate hydroxide 11103-86-9 | Cr2HKO9Zn2 418.911 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 6 |
| T3D1851 | Tefluthrin 79538-32-2 | C17H14ClF7O2 418.734 g/mol |  |
| Pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase i...more Number of Targets: 29 |
| T3D3658 | n-Octyl n-decyl phthalate 119-07-3 | C26H42O4 418.609 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D3648 | Diisononyl phthalate 28553-12-0 | C26H42O4 418.609 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 7 |
| T3D4788 | Simvastatin 79902-63-9 | C25H38O5 418.566 g/mol |  |
| Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite stru...more Number of Targets: 10 |
| T3D3749 | Asteltoxin 79663-49-3 | C23H30O7 418.480 g/mol |  |
| Asteltoxin inhibits mitochondrial respiration by affecting its energy transfer system. It does this by inhibiting Mg2+ and Na+/K+-ATPases. (A3002, A3003, A3031) Number of Targets: 8 |
| T3D1445 | Chromium(III) picolinate 14639-25-9 | C18H12CrN3O6 418.301 g/mol |  |
| Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, ch...more Number of Targets: 5 |
| T3D3779 | Paspalicine 11024-55-8 | C27H31NO3 417.540 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 27 |
| T3D1344 | Mercury(I) oxide 15829-53-5 | Hg2O 417.180 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D4747 | Cyproterone acetate 427-51-0 | C24H29ClO4 416.938 g/mol |  |
| The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In additio...more Number of Targets: 4 |
| T3D2692 | Calcitriol 32222-06-3 | C27H44O3 416.637 g/mol |  |
| The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epi...more Number of Targets: 4 |
| T3D4753 | Spironolactone 52-01-7 | C24H32O4S 416.573 g/mol |  |
| Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-pot...more Number of Targets: 15 |
| T3D2894 | Alfentanil 71195-58-9 | C21H32N6O3 416.517 g/mol |  |
| Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effec...more Number of Targets: 6 |