Browsing Toxins
Displaying toxin 476 - 500 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1760 | Tellurium tetrabromide 10031-27-3 | Br4Te 447.200 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D3645 | Diisodecyl phthalate 26761-40-0 | C28H46O4 446.662 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 4 |
| T3D1176 | Uranocene 11079-26-8 | C16H16U 446.327 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D2483 | Glipizide 29094-61-9 | C21H27N5O4S 445.535 g/mol |  |
| Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the...more Number of Targets: 3 |
| T3D1318 | Ferrous arsenate 10102-50-8 | As2Fe3O8 445.373 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D3104 | Difenacoum 56073-07-5 | C31H24O3 444.521 g/mol |  |
| Difenacoum inhibits the enzyme Vitamin K epoxide reductase. This enzyme is needed for the reconstitution of the vitamin K in its cycle from vitamin K-epoxide, and so d...more Number of Targets: 1 |
| T3D3020 | Mitoxantrone 65271-80-9 | C22H28N4O6 444.481 g/mol |  |
| Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also ...more Number of Targets: 12 |
| T3D3955 | Tetracycline 60-54-8 | C22H24N2O8 444.435 g/mol |  |
| Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mitochondrial protein synthesis. As a result tetracyclines are cytotoxic ...more Number of Targets: 7 |
| T3D3950 | Doxycycline 564-25-0 | C22H24N2O8 444.435 g/mol |  |
| Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mitochondrial protein synthesis. As a result tetracyclines are cytotoxic ...more Number of Targets: 3 |
| T3D0162 | 1,2,3,4,6,7,8,9-Octachlorodibenzofuran 39001-02-0 | C12Cl8O 443.752 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D4988 | 9-(2-Carboxyphenyl)-3,6-bis(diethylamino)xanthylium(1+) 14899-08-2 | C28H31N2O3 443.557 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D4793 | Rhodamine 6g 989-38-8 | C28H31N2O3 443.557 g/mol |  |
| Not Available Number of Targets: 6 |
| T3D1332 | Lead tetraacetate 546-67-8 | C8H12O8Pb 443.400 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D1348 | Mercuric benzoate 583-15-3 | C14H10HgO4 442.820 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D0294 | Manganese arsenate 61136-68-3 | As2Mn3O8 442.653 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 49 |
| T3D2535 | Cinobufagin 470-37-1 | C26H34O6 442.545 g/mol |  |
| Cinobufagin blocks the sodium/potassium pump in heart tissue. (L1083, L1084) Number of Targets: 0 |
| T3D4789 | Troglitazone 97322-87-7 | C24H27NO5S 441.540 g/mol |  |
| Troglitazone is a thiazolidinedione antidiabetic agent that lowers blood glucose by improving target cell response to insulin. It has a unique mechanism of action that...more Number of Targets: 10 |
| T3D2698 | Folic acid 59-30-3 | C19H19N7O6 441.398 g/mol |  |
| Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are...more Number of Targets: 8 |
| T3D0347 | Mercury cadmium telluride 29870-72-2 | CdHgTe 440.600 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 69 |
| T3D1886 | Triantimony disulfide 107373-21-7 | H11S2Sb3 440.500 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D3752 | Arisugacin A 167114-89-8 | C24H24O8 440.443 g/mol |  |
| Arisugacin A is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholines...more Number of Targets: 1 |
| T3D4741 | Aminopterin 54-62-6 | C19H20N8O5 440.413 g/mol |  |
| Aminopterin is an amino derivative of folic acid which binds competitively to the dihydrofolate reductase enzyme to block tetrahydrofolate synthesis. Tetrahydrofolate ...more Number of Targets: 2 |
| T3D1342 | Mercury(I) fluoride 13967-25-4 | F2Hg2 439.180 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D0312 | 4,4-Arsenobis(2-aminophenol) dihydrochloride 139-93-5 | C12H14As2Cl2N2O2 439.001 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D4733 | Quinapril 85441-61-8 | C25H30N2O5 438.516 g/mol |  |
| There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which h...more Number of Targets: 1 |