Browsing Toxins
Displaying toxin 451 - 475 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0813 | Amygdalin 29883-15-6 | C20H27NO11 457.429 g/mol |  |
| Amygdalin can be metabolized into hydrogen cyanide in the stomach causing discomfort or illness. (L402) Organic nitriles decompose into cyanide ions both in vivo and i...more Number of Targets: 0 |
| T3D1446 | Chromium(III) sulfate 10101-53-8 | Cr3H12O14S2 456.202 g/mol |  |
| Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, ch...more Number of Targets: 5 |
| T3D1468 | Nysted reagent 41114-59-4 | C6H12Br2OZn3 456.194 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D0729 | Zinc(II) gluconate 4468-02-04 | C12H22O14Zn 455.704 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D1300 | Arsenic triiodide 7784-45-4 | AsI3 455.635 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D1333 | Lead tungstate 7759-01-5 | O4PbW 455.000 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D3544 | Verapamil 52-53-9 | C27H38N2O4 454.602 g/mol |  |
| Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy...more Number of Targets: 21 |
| T3D2486 | Methotrexate 59-05-2 | C20H22N8O5 454.439 g/mol |  |
| Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. ...more Number of Targets: 11 |
| T3D0350 | Mercury(II) iodide 7774-29-0 | HgI2 454.400 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 51 |
| T3D4862 | Disodium 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonate 2783-94-0 | C16H12N2Na2O7S2 454.384 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4281 | SAICAR 3031-95-6 | C13H19N4O12P 454.283 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1193 | Copper gluconate 527-09-3 | C12H22CuO14 453.841 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D1868 | Dibromotributylantimony 16629-56-4 | C12H27Br2Sb 452.910 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D2978 | Diphenoxylate 915-30-0 | C30H32N2O2 452.587 g/mol |  |
| Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct eff...more Number of Targets: 3 |
| T3D4860 | Allura red AC 25956-17-6 | C18H16N2O8S2 452.458 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D2727 | Cabergoline 81409-90-7 | C26H37N5O2 451.604 g/mol |  |
| Ergoline alkaloids have been shown to have the significant affinity towards the 5-HT1 and 5-HT2 serotonin receptors, D1 and D2 dopamine receptors, and alpha-adrenergic...more Number of Targets: 23 |
| T3D1847 | Flucythrinate 70124-77-5 | C26H23F2NO4 451.462 g/mol |  |
| Pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase i...more Number of Targets: 20 |
| T3D1367 | Cadmium cyclohexane-butyrate 55700-14-6 | C20H34CdO4 450.893 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 19 |
| T3D1564 | Tri-n-decylaluminum 1726-66-5 | C30H63Al 450.803 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D2959 | Phytonadione 84-80-0 | C31H46O2 450.696 g/mol |  |
| Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hep...more Number of Targets: 2 |
| T3D0334 | Lead styphnate 15245-44-0 | C6HN3O8Pb 450.300 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D1032 | Cyhalothrin 68085-85-8 | C23H19ClF3NO3 449.850 g/mol |  |
| Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to th...more Number of Targets: 20 |
| T3D1896 | Triphenylthioantimonate 28609-58-7 | C18H15S3Sb 449.270 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D1360 | Meralluride 140-20-5 | C9H16HgN2O6 448.820 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D2677 | Aripiprazole 129722-12-9 | C23H27Cl2N3O2 448.385 g/mol |  |
| Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex....more Number of Targets: 41 |