Browsing Toxins
Displaying toxin 426 - 450 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1869 | Dichlorotribenzylantimony 19493-17-5 | C21H21Cl2Sb 466.060 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D2836 | Cisapride 81098-60-4 | C23H29ClFN3O4 465.945 g/mol |  |
| Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric...more Number of Targets: 11 |
| T3D3681 | Cytochalasin J 56144-22-0 | C28H35NO5 465.581 g/mol |  |
| Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monome...more Number of Targets: 6 |
| T3D3842 | Fluazinam 79622-59-6 | C13H4Cl2F6N4O4 465.092 g/mol |  |
| Not Available Number of Targets: 30 |
| T3D4647 | Loprazolam 61197-73-7 | C23H21ClN6O3 464.904 g/mol |  |
| Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity...more Number of Targets: 18 |
| T3D3951 | Demeclocycline 127-33-3 | C21H21ClN2O8 464.853 g/mol |  |
| Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mitochondrial protein synthesis. As a result tetracyclines are cytotoxic ...more Number of Targets: 1 |
| T3D3533 | Sorafenib 284461-73-0 | C21H16ClF3N4O3 464.825 g/mol |  |
| Sorafenib interacts with multiple intracellular (CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR-ß). Several of these kin...more Number of Targets: 18 |
| T3D0597 | 2,2',3,3',4,5,5',6,6'-Nonachlorobiphenyl 52663-77-1 | C12HCl9 464.213 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D0596 | 2,2',3,3',4,4',5,6,6'-Nonachlorobiphenyl 52663-79-3 | C12HCl9 464.213 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D0595 | 2,2',3,3',4,4',5,5',6-Nonachlorobiphenyl 40186-72-9 | C12HCl9 464.213 g/mol |  |
| The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more Number of Targets: 7 |
| T3D4001 | Perfluorononanoic acid 375-95-1 | C9HF17O2 464.076 g/mol |  |
| Not Available Number of Targets: 8 |
| T3D3904 | Prohexadione-calcium 127277-53-6 | C20H22CaO10 462.461 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D3869 | Lactofen 77501-63-4 | C19H15ClF3NO7 461.773 g/mol |  |
| Not Available Number of Targets: 22 |
| T3D4962 | Galactosylsphingosine 2238-90-6 | C24H47NO7 461.633 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D2984 | Pimozide 2062-78-4 | C28H29F2N3O 461.546 g/mol |  |
| The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide ...more Number of Targets: 18 |
| T3D0327 | Lead iodide 10101-63-0 | I2Pb 461.000 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D3750 | Aurovertin B 55350-03-3 | C25H32O8 460.517 g/mol |  |
| Aurovertins are a mixed, noncompetitive inhibitors of both ATP hydrolysis and synthesis. They do this by inhibiting the proton-pumping F1F0-ATP synthase by binding to ...more Number of Targets: 3 |
| T3D3953 | Oxytetracycline 79-57-2 | C22H24N2O9 460.434 g/mol |  |
| Tetracyclines target the 28S small subunit of the mitochondrial ribosome thereby deactivation mitochondrial protein synthesis. As a result tetracyclines are cytotoxic ...more Number of Targets: 12 |
| T3D2118 | Octachlorodibenzo-p-dioxin 3268-87-9 | C12Cl8O2 459.751 g/mol |  |
| CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah recepto...more Number of Targets: 4 |
| T3D1537 | Tris(8-hydroxyquinolinato)aluminium 2085-33-8 | C27H18AlN3O3 459.432 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D3940 | Trifloxysulfuron-sodium 199119-58-9 | C14H13F3N5NaO6S 459.333 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D4512 | Fluoxastrobin 361377-29-9 | C21H16ClFN4O5 458.827 g/mol |  |
| Not Available Number of Targets: 25 |
| T3D2844 | Astemizole 68844-77-9 | C28H31FN4O 458.570 g/mol |  |
| Astemizole competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of aste...more Number of Targets: 15 |
| T3D3760 | Fumagillin 23110-15-8 | C26H34O7 458.544 g/mol |  |
| Fumagillin blocks blood vessel formation (angiogenesis) by inhibiting the enzyme methionine aminopeptidase 2. This prevents angiogenesis by arresting endothelial cells...more Number of Targets: 1 |
| T3D1256 | Trioctyltin stannane 869-59-0 | C24H51Sn 458.370 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |