Browsing Toxins
Displaying toxin 2976 - 3000 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4830 | Glycoluril 496-46-8 | C4H6N4O2 142.116 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D3769 | Kojic acid 501-30-4 | C6H6O4 142.109 g/mol |  |
| Kojic acid acts as a competitive and reversible inhibitor of animal and plant polyphenol oxidases (tyrosinases), xanthine oxidase, and D- and some L-amino acid oxidase...more Number of Targets: 4 |
| T3D0223 | Arsenate 15584-04-00 | AsH3O4 141.943 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase. By compe...more Number of Targets: 44 |
| T3D1155 | Sodium permanganate 10101-50-5 | MnNaO4 141.925 g/mol |  |
| Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu...more Number of Targets: 5 |
| T3D1660 | Chlorosulfonyl isocyanate 1189-71-5 | CClNO3S 141.534 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D1052 | Nitromethylidenecyclohexane 27861-39-8 | C7H11NO2 141.168 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D2834 | Ethosuximide 77-67-8 | C7H11NO2 141.168 g/mol |  |
| Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also invol...more Number of Targets: 3 |
| T3D4024 | L-Hypoglycin A 156-56-9 | C7H11NO2 141.168 g/mol |  |
| Generally, hypoglycin is an amino acid and chemically related to lysine. It competitively binds to enzymes used in the catabolism of lysine and is the reason why it an...more Number of Targets: 0 |
| T3D3878 | (±)-Methamidophos 115182-35-9 | C2H8NO2PS 141.129 g/mol |  |
| (±)-Methamidophos is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcho...more Number of Targets: 2 |
| T3D3753 | Butenolide 16275-44-8 | C6H7NO3 141.125 g/mol |  |
| Butenolide causes lipid peroxidation, disrupting the membrane lipid bilayer and causing damage to membrane protiens. It also induces production of reactive oxygen spec...more Number of Targets: 17 |
| T3D4187 | 2-Nonenal 2463-53-8 | C9H16O 140.223 g/mol |  |
| Uremic toxins such as 2-Nonenall are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimul...more Number of Targets: 3 |
| T3D4834 | Metenamine 100-97-0 | C6H12N4 140.186 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1457 | Chromium(II) oxalate 814-90-4 | C2CrO4 140.015 g/mol |  |
| Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, ch...more Number of Targets: 5 |
| T3D1294 | Arsabenzene 289-31-6 | C5H5As 140.015 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D1617 | Silver sulfide 21548-73-2 | AgS 139.933 g/mol |  |
| Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disr...more Number of Targets: 17 |
| T3D0257 | 4-Nitrophenol 100-02-7 | C6H5NO3 139.109 g/mol |  |
| The nitrite in nitrophenols causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a con...more Number of Targets: 12 |
| T3D3579 | 2-Nitrophenol 88-75-5 | C6H5NO3 139.109 g/mol |  |
| The nitrite in nitrophenols causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a con...more Number of Targets: 10 |
| T3D1777 | Bromoacetic acid 79-08-3 | C2H3BrO2 138.948 g/mol |  |
| Organobromide compounds, especially alkylbromides are strong alkylating agents. Consequently they can randomly modify the surfaces of proteins and lipids, leading to ...more Number of Targets: 5 |
| T3D1913 | Potassium perchlorate 7778-74-7 | ClKO4 138.549 g/mol |  |
| The primary and most sensitive target of the perchlorate anion (perchlorate) is the thyroid gland. Perchlorate inhibits the transport of iodide (I-) from the blood int...more Number of Targets: 5 |
| T3D3900 | 2-Phenoxyethanol 122-99-6 | C8H10O2 138.164 g/mol |  |
| 2-Phenoxyethanol is a glycol ether. Glycol ethers can produce toxicity following oxidation to the corresponding aldehyde and alkoxyacetic acid by alcohol dehydrogenase...more Number of Targets: 2 |
| T3D4816 | Salicylic acid 69-72-7 | C7H6O3 138.121 g/mol |  |
| Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostagla...more Number of Targets: 4 |
| T3D0075 | Dimethylarsinate 15132-04-4 | C2H7AsO2 137.997 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through different mechanisms. At the level of the citric acid cycle, arsenic inhibits the pyruvate dehydrogenase and...more Number of Targets: 54 |
| T3D0109 | Barium 7440-39-3 | Ba 137.326 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 22 |
| T3D4435 | Tyramine 51-67-2 | C8H11NO 137.179 g/mol |  |
| Tyramine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 4 |
| T3D4777 | Isoniazid 54-85-3 | C6H7N3O 137.139 g/mol |  |
| Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-per...more Number of Targets: 3 |