Browsing Toxins
Displaying toxin 2951 - 2975 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2558 | Valproic acid 99-66-1 | C8H16O2 144.211 g/mol |  |
| Valproic Acid binds to and inhibits GABA transaminase. This leads to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter i...more Number of Targets: 20 |
| T3D4594 | Caprylic acid 124-07-2 | C8H16O2 144.211 g/mol |  |
| It has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pathway and citric acid cycle functioning, increase oxygen consumption in...more Number of Targets: 0 |
| T3D4938 | 2-Ethylhexanoic acid 149-57-5 | C8H16O2 144.211 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D3968 | 1-Naphthol 90-15-3 | C10H8O 144.170 g/mol |  |
| 1-Naphthol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 5 |
| T3D3970 | 2-Naphthol 135-19-3 | C10H8O 144.170 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D4265 | 3-Methylglutaconic acid 5746-90-7 | C6H8O4 144.125 g/mol |  |
| Accumulation of 3-methylglutaconic acid in the body has been shown to be toxic. 3-methylglutaconyl-CoA hydratase is involved in the metabolism process of 3-methylgluta...more Number of Targets: 0 |
| T3D1200 | Copper(I) bromide 7787-70-4 | BrCu 143.450 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 12 |
| T3D1604 | Silver chloride 7783-90-6 | AgCl 143.321 g/mol |  |
| Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disr...more Number of Targets: 17 |
| T3D4213 | 2-Aminonaphthalene 91-59-8 | C10H9N 143.185 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D2760 | Trimethadione 127-48-0 | C6H9NO3 143.141 g/mol |  |
| Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type c...more Number of Targets: 1 |
| T3D1194 | Copper(I) oxide 1317-39-1 | Cu2O 143.091 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D1821 | Selenium disulfide 7488-56-4 | S2Se 143.090 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D0088 | Bis(2-chloroethyl) ether 111-44-4 | C4H8Cl2O 143.012 g/mol |  |
| BCEE is extremely meabolized, with thiodiglycolic acid (TDGA) being the principal endproduct. The pathway leading to TDGA formation is uncertain, but probably involves...more Number of Targets: 38 |
| T3D4766 | N-Decane 124-18-5 | C10H22 142.282 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D1541 | Magnesium aluminate 12068-51-8 | Al2MgO4 142.266 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D4884 | 2,6-Dimethyl-4-heptanone 108-83-8 | C9H18O 142.239 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4192 | Nonanal 124-19-6 | C9H18O 142.239 g/mol |  |
| Uremic toxins such as nonanal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate...more Number of Targets: 3 |
| T3D1528 | Diisobutylaluminium hydride 1191-15-7 | C8H19Al 142.218 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D0628 | 1-Methylnaphthalene 90-12-0 | C11H10 142.197 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 5 |
| T3D0158 | 2-Methylnaphthalene 91-57-6 | C11H10 142.197 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 4 |
| T3D4195 | 4-Hydroxyoctenal 17449-15-9 | C8H14O2 142.196 g/mol |  |
| Uremic toxins such as 4-Hydroxyoctenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can ...more Number of Targets: 3 |
| T3D3231 | 2-Propenyl 3-methylbutanoate 2835-39-4 | C8H14O2 142.196 g/mol |  |
| Allyl isovalerate has low irritancy potential. It is deduced that one of its metabolites,
isovaleric acid, is toxic, based upon the effects of an inborn error of leuci...more Number of Targets: 0 |
| T3D1047 | (2Z)-1-Methyl-2-(nitromethylidene)pyrrolidine 26171-05-1 | C6H10N2O2 142.156 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D1049 | 2-Nitromethylene-piperidine 50902-03-9 | C6H10N2O2 142.156 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D1062 | (2E)-1-Methyl-2-(nitromethylidene)pyrrolidine 94662-64-3 | C6H10N2O2 142.156 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |