Browsing Toxins
Displaying toxin 2926 - 2950 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4247 | L-2-Hydroxyglutaric acid 13095-48-2 | C5H8O5 148.114 g/mol |  |
| 2-hydroxyglutarate is an oncometabolite. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET f...more Number of Targets: 16 |
| T3D4251 | D-2-Hydroxyglutaric acid 2889-31-8 | C5H8O5 148.114 g/mol |  |
| 2-hydroxyglutarate is an oncometabolite. It is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET f...more Number of Targets: 16 |
| T3D1206 | Copper(II) azide 14215-30-6 | CuN6 147.586 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D3573 | Rubidium nitrate 13126-12-0 | NO3Rb 147.473 g/mol |  |
| Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met...more Number of Targets: 9 |
| T3D4296 | L-Glutamic acid 56-86-0 | C5H9NO4 147.129 g/mol |  |
| Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid ...more Number of Targets: 76 |
| T3D0159 | 1,4-Dichlorobenzene 106-46-7 | C6H4Cl2 147.002 g/mol |  |
| The hepatotoxicity and nephrotoxicity observed in laboratory animals are likely due to the formation of toxic intermediates formed while converting 1,4-DCB to 2,5-dich...more Number of Targets: 40 |
| T3D0172 | 1,2-Dichlorobenzene 95-50-1 | C6H4Cl2 147.002 g/mol |  |
| 1,2-DCB was found to covalently bind to DNA, RNA, and proteins of liver, kidney, lung, and stomach. (L395) Number of Targets: 42 |
| T3D4992 | m-Dichlorobenzene 541-73-1 | C6H4Cl2 147.002 g/mol |  |
| The liver damage caused in rats by 1,3-dichlorobenzene is accompanied by induction of xenobiotic metabolizing enzymes of the phenobarbital type. In rats, a disturbance...more Number of Targets: 0 |
| T3D0375 | Cadmium hydroxide 21041-95-2 | CdH2O2 146.426 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 19 |
| T3D4909 | Benzylideneacetone 122-57-6 | C10H10O 146.186 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4913 | Butyl lactate 138-22-7 | C7H14O3 146.184 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1053 | Thiazolidine, 2-(nitromethylene) 94662-61-0 | C4H6N2O2S 146.168 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D1056 | 2-(Nitromethylidene)-1,3-thiazolidine 94662-60-9 | C4H6N2O2S 146.168 g/mol |  |
| Acts as a neurotransmitter mimic , having both excitatory and depressant effects, eventually blocking postsynaptic nicotinic receptors. (T10) Number of Targets: 5 |
| T3D4319 | L-Glutamine 56-85-9 | C5H10N2O3 146.145 g/mol |  |
| Supplemental L-glutamine's possible immunomodulatory role may be accounted for in a number of ways. L-glutamine appears to play a major role in protecting the integrit...more Number of Targets: 3 |
| T3D4875 | Coumarin 91-64-5 | C9H6O2 146.143 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D1621 | Silver(II) fluoride 7775-41-9 | AgF2 145.865 g/mol |  |
| Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disr...more Number of Targets: 17 |
| T3D2411 | Indium phosphide 22398-80-7 | InP 145.792 g/mol |  |
| Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to...more Number of Targets: 20 |
| T3D4167 | Spermidine 124-20-9 | C7H19N3 145.246 g/mol |  |
| Uremic toxins such as spermidine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimul...more Number of Targets: 17 |
| T3D1815 | Selenic acid 7783-08-6 | H2O4Se 144.970 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D1549 | Sodium aluminum phosphate 7785-88-8 | AlNaO4P 144.943 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D0287 | Gallium arsenide 1303-00-0 | AsGa 144.645 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D2708 | Ethchlorvynol 113-18-8 | C7H9ClO 144.599 g/mol |  |
| Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturate...more Number of Targets: 10 |
| T3D3833 | Ethephon 16672-87-0 | C2H6ClO3P 144.494 g/mol |  |
| Ethephon is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinestera...more Number of Targets: 7 |
| T3D0386 | Cadmium sulphide 1306-23-6 | CdS 144.476 g/mol |  |
| Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more Number of Targets: 19 |
| T3D0742 | Zinc selenide 1315-09-9 | SeZn 144.370 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |